DR4 (TNFRSF10A) (NM_003844) Human Untagged Clone

CAT#: SC111086

TNFRSF10A (untagged)-Human tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TNFRSF10A
• Synonyms: APO2; CD261; DR4; TRAILR-1; TRAILR1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC111086 sequence for NM_003844 edited (data generated by NextGen Sequencing)
  ATGGCGCCACCACCAGCTAGAGTACATCTAGGTGCGTTCCTGGCAGTGACTCCGAATCCC
  GGGAGCGCAGCGAGTGGGACAGAGGCAGCCGCGGCCACACCCAGCAAAGTGTGGGGCTCT
  TCCGCGGGGAGGATTGAACCACGAGGCGGGGGCCGAGGAGCGCTCCCTACCTCCATGGGA
  CAGCACGGACCCAGTGCCCGGGCCCGGGCAGGGCGCGCCCCAGGACCCAGGCCGGCGCGG
  GAAGCCAGCCCTCGGCTCCGGGTCCACAAGACCTTCAAGTTTGTCGTCGTCGGGGTCCTG
  CTGCAGGTCGTACCTAGCTCAGCTGCAACCATCAAACTTCATGATCAATCAATTGGCACA
  CAGCAATGGGAACATAGCCCTTTGGGAGAGTTGTGTCCACCAGGATCTCATAGATCAGAA
  CATCCTGGAGCCTGTAACCGGTGCACAGAGGGTGTGGGTTACACCAATGCTTCCAACAAT
  TTGTTTGCTTGCCTCCCATGTACAGCTTGTAAATCAGATGAAGAAGAGAGAAGTCCCTGC
  ACCACGACCAGGAACACAGCATGTCAGTGCAAACCAGGAACTTTCCGGAATGACAATTCT
  GCTGAGATGTGCCGGAAGTGCAGCAGAGGGTGCCCCAGAGGGATGGTCAAGGTCAAGGAT
  TGTACGCCCTGGAGTGACATCGAGTGTGTCCACAAAGAATCAGGCAATGGACATAATATA
  TGGGTGATTTTGGTTGTGACTTTGGTTGTTCCGTTGCTGTTGGTGGCTGTGCTGATTGTC
  TGTTGTTGCATCGGCTCAGGTTGTGGAGGGGACCCCAAGTGCATGGACAGGGTGTGTTTC
  TGGCGCTTGGGTCTCCTACGAGGGCCTGGGGCTGAGGACAATGCTCACAACGAGATTCTG
  AGCAACGCAGACTCGCTGTCCACTTTCGTCTCTGAGCAGCAAATGGAAAGCCAGGAGCCG
  GCAGATTTGACAGGTGTCACTGTACAGTCCCCAGGGGAGGCACAGTGTCTGCTGGGACCG
  GCAGAAGCTGAAGGGTCTCAGAGGAGGAGGCTGCTGGTTCCAGCAAATGGTGCTGACCCC
  ACTGAGACTCTGATGCTGTTCTTTGACAAGTTTGCAAACATCGTGCCCTTTGACTCCTGG
  GACCAGCTCATGAGGCAGCTGGACCTCACGAAAAATGAGATCGATGTGGTCAGAGCTGGT
  ACAGCAGGCCCAGGGGATGCCTTGTATGCAATGCTGATGAAATGGGTCAACAAAACTGGA
  CGGAACGCCTCGATCCACACCCTGCTGGATGCCTTGGAGAGGATGGAAGAGAGACATGCA
  AAAGAGAAGATTCAGGACCTCTTGGTGGACTCTGGAAAGTTCATCTACTTAGAAGATGGC
  ACAGGCTCTGCCGTGTCCTTGGAGTGA
  
  Clone variation with respect to NM_003844.3
  1322 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003844 unedited
  TAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTTCTGTCTTGTCATAGC
  CAAGCACGCTGCTTCTTGGATTGACCTGGCAGGATGGCGCCACCACCAGCTAGAGTACAT
  CTAGGTGCGTTCCTGGCAGTGACTCCGAATCCCGGGAGCGCAGCGAGTGGGACAGAGGCA
  GCCGCGGCCACACCCAGCAAAGTGTGGGGCTCTTCCGCGGGGAGGATTGAACCACGAGGC
  GGGGGCCGAGGAGCGCTCCCTACCTCCATGGGACAGCACGGACCCAGTGCCCGGGCCCGG
  GCAGGGCGCGCCCCAGGACCCAGGCCGGCGCGGGAAGCCAGCCCTCGGCTCCGGGTCCAC
  AAGACCTTCAAGTTTGTCGTCGTCGGGGTCCTGCTGCAGGTCGTACCTAGCTCAGCTGCA
  ACCATCAAACTTCATGATCAATCAATTGGCACACAGCAATGGGAACATAGCCCTTTGGGA
  GAGTTGTGTCCACCAGGATCTCATAGATCAGAACATCCTGGAGCCTGTAACCGGTGCACA
  GAGGGTGTGGGTTACACCAATGCTTCCAACAATTTGTTTGCTTGCCTCCCATGTACAGCT
  TGTAAATCAGATGAAGAAGAGAGAAGTCCCTGCACCACGACCAGGAACACAGCATGTCAG
  TGCAAACCAGGAACTTTCCGGAATGACAATTCTGCTGAGATGTGCCGGAAGTGCAGCAGA
  GGGTGCCCCAGAGGGATGGTCAAGGTCAAGGATTGTACGCCCTGNAGTGACATCGAGTGT
  GTCCACAAAAATCAGGCATGGACATATATATGGGTGATTNTGGTTGTGACTTNTGGTGNT
  NNCGTGCTGTTGGNGGCTGTGCTGNATGTCTGTTGTTGCATCGGCTCAGGGTGTGGAGGG
  GACCCNAGTGCATGGACAGGNNTGTGTTCTGGCGCTTGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003844 unedited
  GTCCGCGGCCGCATTCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCCAAATTTCCAAAGGT
  ATATGTACTTTAATTGTGACTTGAACTCAAGGTAAATAAATTAAATAATTAATAAATTAA
  CCTTAGCTTACTGGACGGCCACCATCTTATATGCTGTTCCCTTGACTGAAATGTTGTGGG
  GTAAATGACTATATATGAAATGGGACTTATTGGAGGAATTAATGCATCTGATAATGGAGG
  TTGAGAAGTTCCACAACAGGCCATCTGCACAGCAGAGACCCTGAAATGCTGGAAGCAGGA
  CTTAATCCAGCCCAAAAACCTAAGACCCAGGGAAGCCGATGGTGTAATTCTTAGTTCAAG
  GCCAAAATCCTTAGATCCTTCGGGAGGCCACTGGTGTATGCCCTGGAGTCCAAGGGCTAA
  AAATCCTAGACTCTGATGTCCACAGGCAGAAGAGTGTCCCAGCTCCAGGAGATCAGATGG
  ATTTGCTTTTCCTTTTTTTTTTGTTTTCTTCTATCTTGCTCCCCAGTCTGTCGGACGGTG
  CCCCCCCAAATTAAGGGTAGGTCTTTTCCACTCAGTCCACCCGATCGCATGCCAATCCCC
  TCTGGAAACACCCTCGAAGACATGCCCAGAATAATGTCCCAGAAATAATGCCTTACCAGG
  GTTCTAGGGGTTCCTTAATCCTTTCAAATAACACCTCCCATTGACCCCCATGATAAGGAA
  ACACACGGAGGCCAGCTCCAGGGGAGAACCGAATTCTCCTTTGGCATGTGAACCCTCAGC
  CGCGCCATAATTCCTTTCAGGTTTATTTTATTTTATCTTTGAGACCACAGTTCTGCTCTT
  GTGTCCCAAGCTGGAATTGCCTGTGTGCATCTCCAACTCCTCGCCCCCGCGGTTAAATTG
  ATCTCTTCGCGCCAACACTCCCAACCCCCACAAAAATTAAG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003844
• ORF Size: 1407 bp
• Insert Size: 2680
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_003844.2, NP_003835.2
• RefSeq Size: 1723
• RefSeq ORF: 1407
• Locus ID: 8797
• Domains: DEATH, TNFR
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity
• Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]