TRIB2 (NM_021643) Human Untagged Clone

CAT#: SC111247

TRIB2 (untagged)-Human tribbles homolog 2 (Drosophila) (TRIB2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRIB2
• Synonyms: C5FW; GS3955; TRB2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_021643 edited
  ATGAACATACACAGGTCTACCCCCATCACAATAGCGAGATATGGGAGATCGCGGAACAAA
  ACCCAGGATTTCGAAGAGTTGTCGTCTATAAGGTCCGCGGAGCCCAGCCAGAGTTTCAGC
  CCGAACCTCGGCTCCCCGAGCCCGCCCGAGACTCCGAACTTGTCGCATTGCGTTTCTTGT
  ATCGGGAAATACTTATTGTTGGAACCTCTGGAGGGAGACCACGTTTTTCGTGCCGTGCAT
  CTGCACAGCGGAGAGGAGCTGGTGTGCAAGGTGTTTGATATCAGCTGCTACCAGGAATCC
  CTGGCACCGTGCTTTTGCCTGTCTGCTCATAGTAACATCAACCAAATCACTGAAATTATC
  CTGGGTGAGACCAAAGCCTATGTGTTCTTTGAGCGAAGCTATGGGGACATGCATTCCTTC
  GTCCGCACCTGCAAGAAGCTGAGAGAGGAGGAGGCAGCCAGACTGTTCTACCAGATTGCC
  TCGGCAGTGGCCCACTGCCATGACGGGGGGCTGGTGCTGCGGGACCTCAAGCTGCGGAAA
  TTCATCTTTAAGGACGAAGAGAGGACTCGGGTCAAGCTGGAAAGCCTGGAAGACGCCTAC
  ATTCTGCGGGGAGATGATGATTCCCTCTCCGACAAGCATGGCTGCCCGGCTTACGTAAGC
  CCAGAGATCTTGAACACCAGTGGCAGCTACTCGGGCAAAGCAGCCGACGTGTGGAGCCTG
  GGGGTGATGCTGTACACCATGTTGGTGGGGCGGTACCCTTTCCATGACATTGAACCCAGC
  TCCCTCTTCAGCAAGATCCGGCGTGGCCAGTTCAACATTCCAGAGACTCTGTCGCCCAAG
  GCCAAGTGCCTCATCCGAAGCATTCTGCGTCGGGAGCCCTCAGAGCGGCTGACCTCGCAG
  GAAATTCTGGACCATCCTTGGTTTTCTACAGATTTTAGCGTCTCGAATTCAGCATATGGT
  GCTAAGGAAGTGTCTGACCAGCTGGTGCCGGACGTCAACATGGAAGAGAACTTGGACCCT
  TTCTTTAACTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021643 unedited
  NTGTCAACATTTGTATACGACTCATATAGGGCGGCCGCGATTCGGCACGAGGCGGGGTGA
  TTGCAAATTATTCCAGGACGAGATCCAGTTCTCCAGCGGGAAAGGGGCAAAGGAACGCCG
  CGCGTTGGAAGGGCCAGGGACGCAGCTCCCCTTGCAGCGCCCGCAGGACCCCCGCAAGCT
  CGTGCCGGCGAAATCGGAGACCGCCGATCTGTCCTCGTTCTCTCCTGCACGTCTGGCTGC
  ATTCGGAGGAAGACCTGGGGCGCGAGCGAGCGGCGACAGCATGAGCCTGTGCTGACCTCC
  GCGCGGCGGGCCGAGCCCAGGGCTTTGTCGCGGTACCTGCGCCCAGCCCGCGCCGCAACT
  CTGTGCCCAGCTTTTGCAATCTTTTGTTGGCAGCGCTGACCGCACCAAGTTAAATGCTCC
  CTTGCAATTTTTCTTTTTTTTGTTTGTTTGTTTAATTTTTGGAGAGCTCGCGATCTTGGA
  AAAGCCTCAGACGCCATCTACAGTTAAAACGTAGGTAACTGCCCTCTCCCGCACCCCCCC
  CTTACACGCCCCCCACCCTTTCCACCAAAAAAAGGGGGTGCAGCGCGGATTCTGGCTGCC
  GTGCGTCGCCAGCCGGTAGACCCGTGCTTGTTTCCTTTCTCTTTTTGTTTGGCTTCTAAC
  GCGTTGGGACTGAGTCGCCGCCGTGAGCTCCCCGAAGACTGCACAAACTACCGCGGGCTC
  CTCCGCCCCGTCTGCGATTCGGAAGCCGGCCTGGGGGNTCGCGTCGGGAGCCCTGGCGCT
  GCAGCTCCGCACCTTAGCAGCCCGGGTACTCATCCAGATCCACGCCGGGACACCACACCA
  GAGTACTAAAAGTGCGGCGATTCTGCACATCGNCGACTGCTTTGGGGTAACAAAAGACCC
  GAGTTGCCTGN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021643 unedited
  NNTTCCTTGNCCGCGGCCGCATTCTANATCGAGTTTTTTTTTTTTTTTTTTTAGTTAAAT
  ACGCACAATTTTATTGATTGAAGAGATTAGGACAAAAACATTAAACCAAATACAGGACAA
  AGCACCAGAGGCCATAGATCCCCACCATGCATGTCACCAACCTCTCCTCCTCCAAGGTAC
  TTAAAAAATAGGGGAGAGGGGAAAAAAAGGTCCTTCTTGACACAGCACCATCTTCAGAAT
  GTTAAAAAAAAAAAAAAACCTTCTCTCCTTTCTATCTTCCATTAGCAAAATAGAATCAAG
  GGCAAATCCATGGCCGCCTTGTCTCCTGGTTACGAAGGGTGAAGCCGCCCTCCTGGGAAC
  GTGAGGACAGGGCTCCTGCTGCGCAGGCATAAAGCATCCAAGAGTCTGCACATACATGCC
  ACACACTATTATGAAGCACAGATTCAAGTAACATTTACATACTAGAGTCCACGTGTCACC
  TACCCAAAAACAGGACCATTTCACAAAACATATACAGGCAGTCAAATCCGAACAAGTGAG
  GTACTGGGAACACAAATATTTATGCCAAAAGAGTTCTGTATCATACAGCAATAGAAAAGC
  CGTAATAAAAAACATTTTGCCACTCGAAATCAAATAAAGCTATCTAGAAAAGCCAAGTAA
  AAGGTTATTTCAGAGACAGAAATACTCAAACAAGGAAAAAGAATTATAAATGTTAACTAC
  AGCATGTAATATGTCATCCCAAGTCACCCCGTAATTGGAGTACTGGCTAANTACATCACA
  ATGTGACATTTTCCTTACTAAATAGAAGAGTTCTTGAAATACAAAAGTGCGTATTGGGAT
  GAGAGCTGGTTTTATTTATATCATATAGCTTCAGCTAATTATCCTTCCGCTTGCCCTACT
  GAGGNTTTTGCCAAACAGAGGGCCTTACAGCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021643
• ORF Size: 1032 bp
• Insert Size: 4230
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_021643.1, NP_067675.1
• RefSeq Size: 4221
• RefSeq ORF: 1032
• Locus ID: 28951
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) encodes a functional protein.