UGT (UGT1A9) (NM_021027) Human Untagged Clone

CAT#: SC113006

UGT1A9 (untagged)-Human UDP glucuronosyltransferase 1 family, polypeptide A9 (UGT1A9)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UGT1A9
• Synonyms: HLUGP4; LUGP4; UDPGT; UDPGT 1-9; UGT-1I; UGT1-09; UGT1-9; UGT1.9; UGT1A9S; UGT1AI; UGT1I
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC113006 sequence for NM_021027 edited (data generated by NextGen Sequencing)
  ATGGCTTGCACAGGGTGGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGT
  GGCTTTGCCGAGGCAGGGAAGCTACTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACC
  ATGAGGTCGGTGGTGGAGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCA
  GAGGTGAGTTGGCAACTGGGAAGATCACTGAATTGCACAGTGAAGACTTATTCAACTTCA
  TATACCCTGGAGGATCTGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCA
  CAAGTACGAAGTATATATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTT
  TTTTCAAATTGCAGGAGTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGT
  TCTTTTGATGCAGTGTTTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATAT
  TTCTCCCTCCCCTCCGTGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGT
  GCACAGTGCCCTGCTCCTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCC
  ATGACTTTCAAGGAGAGAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGC
  CACCGTTTTTTCAAAAATGCCCTAGAAATAGCCTCTGAAATTCTCCAAACACCTGTTACG
  GAGTATGATCTCTACAGCCACACATCAATTTGGTTGTTGCGAACGGACTTTGTTTTGGAC
  TATCCCAAACCCGTGATGCCCAACATGATCTTCATTGGTGGTATCAACTGCCATCAGGGA
  AAGCCGTTGCCTATGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTG
  GTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCT
  GATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCG
  AATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCAC
  CCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGC
  AATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGC
  ATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTA
  GAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTC
  TCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAG
  TTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGG
  TACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCC
  TTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGA
  GTTAAGAAAGCCCACAAATCCAAGACCCATTGA
  
  Clone variation with respect to NM_021027.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_021027 unedited
  GCAATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGACTGTATCATA
  GGAGCTTAGATTCCCAGCTGCTTGCTCTCAGCTGCAGTTCTCTGATGGCTTGCACAGGGT
  GGACCAGCCCCCTTCCTCTATGTGTGTGTCTGCTGCTGACCTGTGGCTTTGCCGAGGCAG
  GGAAGCTACTGGTAGTGCCCATGGATGGGAGCCACTGGTTCACCATGAGGTCGGTGGTGG
  AGAAACTCATTCTCAGGGGGCATGAGGTGGTTGTAGTCATGCCAGAGGTGAGTTGGCAAC
  TGGGAAGATCACTGAATTGCACAGTGAAGACTTATTCAACTTCATATACCCTGGAGGATC
  TGGACCGGGAGTTCAAGGCTTTTGCCCATGCTCAATGGAAAGCACAAGTACGAAGTATAT
  ATTCTCTATTAATGGGTTCATACAATGACATTTTTGACTTATTTTTTTCAAATTGCAGGA
  GTTTGTTTAAAGACAAAAAATTAGTAGAATACTTAAAGGAGAGTTCTTTTGATGCAGTGT
  TTCTCGATCCTTTTGATAACTGTGGCTTAATTGTTGCCAAATATTTCTCCCTCCCCTCCG
  TGGTCTTCGCCAGGGGAATACTTTGCCACTATCTTGAAGAAGGTGCACAGTGCCCTGCTC
  CTCTTTCCTATGTCCCCAGAATTCTCTTAGGGTTCTCAGATGCCATGACTTTCAAGGAGA
  GAGTACGGAACCACATCATGCACTTGGAGGAACATTTATTATGCCACCGTTTTTTCAAAA
  ATGCCCTAGAAATAGCCTCTGNAATTCTCCANACACCTGTTACNGAGTATGATCTCTACA
  GCCCACATCAATTTTGTTTGTGCGAACGNACTTTNGTNTGNACTATCCCAAACCCGTGAT
  GCCCACATGATCTTCATTGGNTGTATCAACTGCATCAGGGAAAGCCCCGTGCTATNGAAT
  TTGAAGCTACATTNATGCTCTGAGACATGNNATTGTGGTTTCTCTTGGGATCAG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_021027 unedited
  ATCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTAAATAGAATTTATAT
  AAATTTATTAATTTATTTTTAGTTGTAGGAAACATCAGAAAAAAGTAAACTTGCCCAGCA
  CTTCATAGCTGTATTTTGGGTTTTTATCAAATTCAGCTCCATTTGACATAAGCAATGATT
  ATCTTCTCAAATACACCACCCACCAATTTCATAGCATCATTCTTTTTCCCCAAAGCAAGA
  AATCATATGCTGTTCTCAGTGCACTCCAAGCCATTCATTCATTTCACCTACACTCTAAAG
  GTACAAAGCTTCCCTTCTTTAAACACACAAGGTGGCACCTATGAAGCACGACAGAGATGA
  GGACTGACCATTATTGGTTAAGGATCAATTGCAACCATCTGCAGAAGCCAAAAGATAAGA
  TTAAAACTGCCATTTGCAGTAGGGGCAGCCGTGGGACCACCTTTGAATCCCGCACTCCCA
  AACAGGCCATGTTTCAGAGTAAGAAAAGTAATCTAGAATGCCAGCCTGTCTGCACGTCCT
  CTGAAAAATGGCACATGTCATCCTGATCAAAGACACCAGAGGGGGCACGATACATATTCA
  AATANTCTTACTGACTAGCGAGTCTATTATTTTTATTTAAGAAGATTTTTTAAAGCACTC
  TGGGGCTGATTAANTTATGCAAAGTATTTCCCTAAATAGAAATAAATGAATTNNNACACT
  GATCTGTTTTCAGTTTTGAAATGACTAGGGAATGTNNTCAAAATTACCCTATTNCCACCC
  ACTTCTCATGGGTCTTGGATTTGTGGGCTTTCTAACTCGCCCTTTTTCCCCAGCATTTTC
  GGTGGCATAAGCCCCCATTTAAAGTGATGAAGCCACTGTCACACGACGCCAGAAGGAACC
  ATNCCGTCCANGGATGTTACTGGTACCAGTGGAGTCTGGGGCTGGGGGCCCAAGTTTGNC
  CCCCCCTTTGGCTAATAAAAATTCCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_021027
• ORF Size: 1593 bp
• Insert Size: 2750
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_021027.2, NP_066307.1
• RefSeq Size: 2395
• RefSeq ORF: 1593
• Locus ID: 54600
• Domains: UDPGT
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Androgen and estrogen metabolism, Ascorbate and aldarate metabolism, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Retinol metabolism, Starch and sucrose metabolism
• Gene Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]