KPI2 (LMTK2) (NM_014916) Human Untagged Clone

CAT#: SC114760

LMTK2 (untagged)-Human lemur tyrosine kinase 2 (LMTK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LMTK2
• Synonyms: AATYK2; BREK; cprk; hBREK; KPI-2; KPI2; LMR2; PPP1R100
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_014916 edited
  ATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTCCTCCTGATC
  GCCGGCAGTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCGCCACCTGCT
  GCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGTGCAGTTTAATAATATTAATAGTG
  TTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAGGAATTTGAA
  GATAATTTTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCCTCTGTTCAG
  TCCCCAGCAGAGGTCTTCACACTTTCAGTACCAAATATTTCACTCCCAGCTCCCTCGCAA
  TTCCAGCCTTCTGTAGAGGGATTGAAGTCTCAAGTTGCCCGCCACAGTCTAAACTACATA
  CAGGAAATTGGAAATGGCTGGTTTGGAAAGGTTCTCTTGGGAGAGATTTACACGGGCACT
  AGCGTAGCAAGAGTCATCGTGAAGGAGTTAAAAGCAAGTGCCAACCCAAAGGAACAAGAT
  ACTTTTTTGAAAAATGGAGAACCTTACTACATTCTTCAGCATCCAAATATTCTTCAGTGT
  GTTGGACAGTGCGTAGAAGCGATTCCCTACCTCCTGGTGTTTGAGTTCTGTGACTTGGGT
  GACCTGAAGGCGTATCTGCGCAGCGAGCAGGAGCACATGCGGGGGGACTCACAGACCATG
  CTGCTGCAGAGGATGGCGTGCGAGGTCGCCGCGGGGCTGGCCGCCATGCACAAGCTGCAC
  TTCCTGCACAGTGATTTAGCCCTGCGGAATTGTTTTCTCACCTCCGACTTAAATGTGAAA
  GTGGGAGATTACGGAATAGGATTCAGCAGGTACAAGGAGGATTATATTGAAACAGATGAT
  AAAAAAGTTTTCCCTCTGCGATGGACTGCTCCAGAATTAGTAACCAGCTTTCAAGACAGA
  CTGCTAACTGCAGATCAGACTAAGTATAGTAATATCTGGTCTCTGGGTGTGACACTTTGG
  GAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTTCCAACTTAGATGTCCTCAAC
  CAAGTCATTAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCT
  GATAGATGGTATGAAGTCTTACAGTTCTGTTGGCTGTCACCAGAAAAGAGACCCGCGGCT
  GAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGAGCCAGCGGGACTCAGAGGTC
  GACTTTGAACAGCAGTGGAACGCTCTGAAGCCGAACACAAACAGCAGAGACTCCTCCAAC
  AATGCTGCATTCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAAATGGAG
  GAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCTTCGAGTATGTCTGGGAGGCC
  GCTAAGCACGACCACTTTGACGAGCGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTAC
  ACGAGCATCTTCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGGCCCGGA
  AAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCCCTGGAGTGGTTCCTGTTTTT
  GATGCCCACAACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGT
  AGTAACTTGGAGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAATCCAGAA
  AGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGAGCGTTGAACTTGAGGAGTCC
  AGTACAGATGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGG
  GACTTACACGTGACCAGTGGCCCCGAGAGCCCTTTCAACAATATATTTAATGATGTGGAC
  AAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACTTAATGGAATTAAACGGAGTT
  CAAGCCGACTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTC
  ATAACAGGCCACTTTGAGAAAGAAAAGCCCCGTAAGATTTTTGACAGTGAGCCTCTCTGC
  CTATCAGATAATCTTATGCACCAAGATAATTTTGATCCATTGAATGTTCAAGAATTGTCA
  GAAAACTTTTTATTTCTTCAAGAGAAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAA
  CACATAAATGATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATGTTAGAA
  ACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTGCTGAAAATAAGCCAGGCATG
  TCTTTGTTGCAGGAAAACGTAAGCACAAAGGGTGACGATACAGATGTCATGCTCACAGGT
  GACACTTTGAGCACCTCATTGCAGTCTTCCCCAGAAGTGCAGGTACCTCCTACCTCCTTC
  GAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCACTCCCAACACAGGGAGAAACC
  CAGCCCACGTGTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCA
  GACGCTGTGACTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGCCTGGAT
  AACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCCTGCGACTCACCGAAAGTGAC
  TCTGTTCTTGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAA
  CTGGGACAGGAATTGCACAATAAACCATTTTCGGAAGACCATCACAGTCATCGCCGGCTA
  GAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCAATTCTAAAGACGCAGCAAAA
  GAAGCAGGCTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAG
  GACAGCTTGTCAGCACCCTTCCCAGCCTCTGAGCCGTCCCTGGAAACCCCGGACTCTCTG
  GAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAGGATCTCACACTCCCCAGAAA
  CTAGTGCCCCCCGATAAGCCGGCAGACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCC
  GAGTGGACCTTGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACCACGGGC
  GATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTGTCATCTCAGATGCCGGCGAT
  GGTCACAGAGGCACAGAAGTGACCCCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATAC
  CGAGACTCTGCGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAGGAGGTC
  CCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGCAGCCCCTACCCGAGCCAGTC
  CTCCCCGAGCAAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCA
  GATGAAAGTTGTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCCACGCCG
  GAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCACGGAAGACGAGGCCAGCAGT
  CCCTGGAGTGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGAT
  CGCCCCTGCACCCTCGCTTCCACGGGGACCAACACGAACGAACTCCTTGCCTACACCAAT
  TCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCCCGAAGTTGAAGGAGCCGGAC
  ATCGAAGGGAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGAC
  GGGATGGATGCAGACGAGGAGGACGAAAACAGCGACGACTCGGACGAGGACCTGCGGGCC
  TTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGACCGAGCACCCCGTGCCCATC
  ATCCTCAGCAACGAGGACGGAAGGCACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAAT
  GCCCCCGACCCACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTTTTCGAT
  GATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCAAAGAGCTGGGGCCCTGTGGA
  GGAGAGGCGTGCGGCCCGGACCTGAGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTG
  AGCAGGTGCATCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAGTGGGAT
  GATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAAGTAACCTGCTCAGCTCCAAG
  CCTTCTCTCCAAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAG
  AGCTGGCCGCACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATTGCCAGC
  TTTTCCCTCACACACCTGACCGACTCGGACATCGAGCAGGGCGGAAGCAGCGAAGACGGA
  GAAAAGGACTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014916 unedited
  AACGTCACGCGCCCCTTGCCGCTAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAA
  GCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG
  CGAATTCGGCACGAGGGCGGCGGGAGCGCGGCTTCCCAGGCCCGCCGCTCCGCAGGGCTG
  CTGGCGTTGCTGCTGTTGAGAGGCGGCGGCGGCGGCGCAGGCGGGCGGGAAGGATGGTGT
  TTCTGCGACTGGAGCGGCAGGTGCGGACCGGGAGCCGGACCGAGGTTTGGCAGAAGCAAC
  GTGTGCTCGGGAGCAACCGGCGCGGGTGCCACTGAGGCAGCGGAGGGAGGCAGGATCGAC
  TGACGGGCGAACGGACGGACGGACGGAAGGCGACTCGAGGGCCGGCCCCGGAGCCGCGCC
  GTGGGCGAGATGCCGGGGCCGCCGGCGTTGCGGCGGAGGCTGCTGCTGCTGCTGCTGGTC
  CTCCTGATCGCCGGCAGTGCTGGGGCCGCGCCACTTCCGCAAACAGGTGCAGGGGAGGCG
  CCACCTGCTGCAGAAGTTTCCTCATCTTTTGTGATCCTGTGTGTGTGCAGTTTAATAATA
  TTAATAGTGTTAATTGCAAACTGTGTATCCTGCTGTAAGGACCCAGAAATAGACTTTAAG
  GAATTTGAAGATAATTTTGATGATGAGATAGATTTCACACCACCAGCAGAAGACACTCCC
  TCTGTTCAGTCCCCAGCAGAAGTCTTCACACTTTCAGTACCAAATATTTCACTCCCAGCT
  CCCTCGCAATTCCCAGCCTCTGTAGAGGGATGAAGTCTCAAGTGCCCGCACAGTCTAACT
  CCTACAGGAAATGGAAAGGCTGGTTTGAAAAGGTCTCTTGGGAGAGATTCACGGGCCCAG
  CGTAACAGGA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014916
• ORF Size: 4512 bp
• Insert Size: 5000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_014916.2, NP_055731.2
• RefSeq Size: 5602
• RefSeq ORF: 4512
• Locus ID: 22853
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Gene Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]