Angiotensin II Type 1 Receptor (AGTR1) (NM_009585) Human Untagged Clone

CAT#: SC115571

AGTR1 (untagged)-Human angiotensin II receptor, type 1 (AGTR1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: AGTR1
• Synonyms: AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_009585, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGATTCTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGATTGTCCCAAAGCTGGAAGGC
  ATAATTACATATTTGTCATGATTCCTACTTTATACAGTATCATCTTTGTGGTGGGAATATTTGGAAACAG
  CTTGGTGGTGATAGTCATTTACTTTTATATGAAGCTGAAGACTGTGGCCAGTGTTTTTCTTTTGAATTTA
  GCACTGGCTGACTTATGCTTTTTACTGACTTTGCCACTATGGGCTGTCTACACAGCTATGGAATACCGCT
  GGCCCTTTGGCAATTACCTATGTAAGATTGCTTCAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTT
  TCTACTCACGTGTCTCAGCATTGATCGATACCTGGCTATTGTTCACCCAATGAAGTCCCGCCTTCGACGC
  ACAATGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGGCTTGGCCAGTTTGCCAGCTA
  TAATCCATCGAAATGTATTTTTCATTGAGAACACCAATATTACAGTTTGTGCTTTCCATTATGAGTCCCA
  AAATTCAACCCTCCCGATAGGGCTGGGCCTGACCAAAAATATACTGGGTTTCCTGTTTCCTTTTCTGATC
  ATTCTTACAAGTTATACTCTTATTTGGAAGGCCCTAAAGAAGGCTTATGAAATTCAGAAGAACAAACCAA
  GAAATGATGATATTTTTAAGATAATTATGGCAATTGTGCTTTTCTTTTTCTTTTCCTGGATTCCCCACCA
  AATATTCACTTTTCTGGATGTATTGATTCAACTAGGCATCATACGTGACTGTAGAATTGCAGATATTGTG
  GACACGGCCATGCCTATCACCATTTGTATAGCTTATTTTAACAATTGCCTGAATCCTCTTTTTTATGGCT
  TTCTGGGGAAAAAATTTAAAAGATATTTTCTCCAGCTTCTAAAATATATTCCCCCAAAAGCCAAATCCCA
  CTCAAACCTTTCAACAAAAATGAGCACGCTTTCCTACCGCCCCTCAGATAATGTAAGCTCATCCACCAAG
  AAGCCTGCACCATGTTTTGAGGTTGAGTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_009585 unedited
  GGCGCGGGGGGNAAGNNGTATCCCTCCCCCCCCNGGNGGGTGCGGGATTTGAAAACTGCA
  TTCATGTGAGGGCGGCCACGCAATTCGCACGAGGACAGCCAGGNACCCCAGGCAGCAGCG
  AGTGACAGGACGTCTGGACCGGCGCGCCGCTAGCAGCTCTGCCGGGCCGCGGCGGTGATC
  GATGGGGAGCGGCTGGAGCGGACCCAGCGAGTGAGGGCGCACAGCCGGGACGCCGAGGCG
  GCGGGCGGGAGACCCGCTTTTTTTCAGCCGGCCCTCGGCGGGACGTGACGCAGCGCCCGG
  GGCGCGGGTGTATTTGATATAGTGTTTGCAACAAATTCGACCCAGGTGATCAAAATGATT
  CTCAACTCTTCTACTGAAGATGGTATTAAAAGAATCCAAGATGATTGTCCCAAAGCTGGA
  AGGCATAATTACATATTTGTCATGATTCCTACTTTATACAGTATCATCTTTGTGGTGGGA
  ATATTTGGAAACAGCTTGGTGGTGATAGTCATTTACTTTTATATGAAGCTGAAGACTGTG
  GCCAGTGTTTTTCTTTTGAATTTAGCACTGGCTGACTTATGCTTTTTACTGACTTTGCCA
  CTATGGGCTGTCTACACAGCTATGGAATACCGCTGGCCCTTTGGCAATTACCTATGTAAG
  ATTGCTTTAGCCAGCGTCAGTTTCAACCTGTACGCTAGTGTGTTTCTACTCACGTGTCTC
  AGCATTGATCGATACCTGGCTATTGGTCACCCCAATGAGTCCCGCCTTTCGACGCACAAT
  GGCTTGTAGCCAAAGTCACCTGCATCATCATTTGGCTGCTGGCAGGCTTGGGCCAGTTTG
  CCAGCTATTATCCATCGAAATGTATTTTTCATTGAGAACACCAATATACAGTTTGTGCTT
  TCCATTATGAGTCCCAAAATTCAACCCTTCCATAGGGCTGGGCCTGACCCAAAAATACGG
  GGTGTCCTGTTCCCTTTTTTGACATCTTTACAAGTATACTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_009585 unedited
  GGATTTATTTTTTTTTTAAGTAAATTAACTTTGGCCGAATTTAATCAATTAACAGCAGTT
  TAGAGATATAGATATACATATATATATATGTGTAGAATATATACTTTTTTTAAACAGGAA
  GGCATACTTTATGATATATAATCTTTTTACCACAAACTATATACACTTCTCAGATATTAA
  ATCAAACTAATATACTAGGAAGACACTACTACTTGGGACCAGTGCAGCACCTTTACAAGT
  AGTTTAACTTTTATATGTGACTTTAGTAACACCATTATACAAATAAGCCATCTTACGGGC
  ATTGTTTTGGCAGTGTAAACCTATAAGACACAGGTTGAATTTCACAAAAAGATCTGCAAC
  TTGACGACTACTGCTTAGCATATCTTTGTACAAAATGTGCAGTACCAGGTGCAAGTGTAG
  CACAGTTGCTAATAGCTGAAAACCGGCACGAAAACTTTACTGCCCTTTGGAAACTGGACA
  GAACAATCTGGAACTCTCATCTCCTGTTGCTCCTCTAACGATTTAATATATTCTAAATAC
  CTTTATGTGGAAATAAAAAATAACAGGACAAAAGCAGGCTAGGGAGATTGCATTTCTGTC
  AGTAAAATTTCTCAAATCAACACATTCATCGAGTTTCTGACATTGTTCTTCGAGCAGCCG
  TCATCTGTCTAATGCANAATGTGGCTNTGCTTTGTCTTGTTGCANAAGGAAAGAAAAGCT
  NTTGTTCAGAGCTNTAGAAAAGTCGGNTCAGTCCACATAATGCATTTTCTCCTTCAATTC
  TNGAAAGTAGCTAATGCTCATTTGGTAGTGAAGTGCTGCAGAGAATGTTCTCTTGCTCCT
  TCTTCACANAATACTTATGGACAGGTTNCGACATGTCACTCACCTCAAACATGTGCAGGC
  TTCTGGTGATGAGCTACATATCTGAGGGCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_009585
• Insert Size: 2260 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_009585.2, NP_033611.1
• RefSeq Size: 2278 bp
• RefSeq ORF: 1080 bp
• Locus ID: 185
• Cytogenetics: 3q24
• Domains: 7tm_1
• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Renin-angiotensin system, Vascular smooth muscle contraction
• Gene Summary: 'Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020]'
  Transcript Variant: This variant (2), also known as pC1 or hAT1R-A, lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).