PI 3 Kinase p85 beta (PIK3R2) (NM_005027) Human Untagged Clone

CAT#: SC116980

PIK3R2 (untagged)-Human phosphoinositide-3-kinase, regulatory subunit 2 (beta) (PIK3R2)


  "NM_005027" in other vectors (6)

Reconstitution Protocol

USD 310.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PIK3R2
Synonyms MPPH; MPPH1; p85; p85-BETA; P85B
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_005027 edited
ATGGCGGGCCCTGAGGGCTTCCAGTACCGCGCTCTGTACCCGTTCCGCCGGGAGCGGCCG
GAGGACCTGGAGCTGCTGCCCGGCGACGTGCTGGTAGTGAGCCGGGCGGCCTTGCAGGCG
CTGGGCGTGGCCGAGGGTGGCGAGCGCTGCCCACAGAGCGTGGGCTGGATGCCCGGCCTC
AACGAGCGCACACGGCAGCGAGGTGACTTCCCTGGCACCTATGTGGAGTTCCTGGGGCCC
GTGGCCCTGGCCCGGCCCGGCCCTCGCCCACGGGGCCCCCGCCCACTGCCCGCCAGGCCC
CGTGATGGGGCCCCTGAGCCAGGCCTCACACTCCCCGACTTGCCCGAGCAGTTCTCCCCA
CCTGATGTGGCTCCCCCTCTTCTGGTGAAGCTTGTGGAGGCCATTGAAAGGACAGGGCTG
GACAGCGAATCTCACTACCGCCCGGAGCTGCCCGCACCGCGTACAGACTGGTCCCTGAGC
GACGTGGATCAGTGGGACACGGCAGCCCTGGCTGACGGCATTAAGAGCTTCCTGCTGGCA
CTGCCCGCGCCGCTCGTGACCCCCGAGGCCTCGGCCGAGGCGCGCCGGGCCCTGCGGGAG
GCCGCGGGGCCCGTGGGGCCGGCGCTGGAGCCACCGACGCTGCCGCTGCACCGCGCGCTC
ACGCTGCGCTTCCTGCTCCAGCACCTGGGCCGCGTGGCCCGCCGCGCCCCGGCCCTGGGT
CCCGCGGTCCGGGCCCTGGGCGCCACCTTTGGGCCGCTGCTGCTGCGCGCGCCGCCGCCG
CCGTCCTCGCCGCCGCCAGGGGGCGCTCCCGACGGGAGTGAGCCCAGCCCTGACTTCCCG
GCGCTGCTGGTGGAGAAGCTGCTTCAGGAACACTTGGAAGAGCAGGAGGTTGCGCCCCCA
GCGCTGCCGCCTAAACCCCCCAAGGCAAAGCCGGCCCCCACAGTCCTGGCCAATGGAGGG
AGCCCACCCTCCCTGCAGGATGCTGAGTGGTACTGGGGGGACATTTCAAGGGAGGAGGTG
AACGAGAAACTCCGGGACACTCCCGATGGCACCTTCCTAGTCCGAGATGCTTCTAGCAAG
ATCCAGGGCGAGTACACGCTGACCCTCAGGAAAGGCGGGAACAATAAGCTGATCAAGGTC
TTCCACCGAGATGGGCACTATGGCTTCTCAGAGCCACTCACCTTCTGCTCCGTTGTGGAC
CTCATCAATCACTACCGCCACGAGTCTCTGGCCCAGTACAATGCCAAGCTGGACACACGG
CTCCTCTACCCTGTGTCCAAATACCAGCAGGACCAGATTGTCAAGGAGGACAGCGTGGAG
GCAGTGGGCGCCCAGCTTAAGGTCTATCACCAGCAGTACCAGGACAAGAGCCGCGAGTAT
GACCAGCTTTATGAAGAGTACACACGGACCTCCCAGGAGCTGCAGATGAAGCGTACTGCA
ATTGAGGCCTTCAATGAGACTATCAAGATCTTTGAAGAGCAGGGCCAGACTCAAGAGAAA
TGCAGCAAGGAATACCTGGAGCGCTTCCGGCGTGAGGGCAACGAGAAAGAGATGCAAAGG
ATCCTGCTGAACTCCGAGCGGCTCAAGTCCCGCATTGCCGAGATCCATGAGAGCCGCACG
AAGCTGGAGCAGCAGCTGCGGGCCCAGGCCTCGGACAACAGAGAGATCGACAAGCGCATG
AACAGCCTCAAGCCGGACCTCATGCAGCTGCGCAAGATCCGAGACCAGTACCTCGTGTGG
CTCACCCAGAAAGGCGCCCGGCAGAAGAAAATCAACGAGTGGCTGGGGATTAAAAATGAG
ACTGAGGACCAGTACGCACTCATGGAGGACGAGGACGATCTCCCGCACCACGAGGAACGC
ACTTGGTACGTGGGCAAGATCAACCGCACGCAGGCAGAGGAGATGCTGAGTGGCAAGCGG
GATGGCACCTTCCTCATCCGCGAGAGCAGCCAGCGGGGCTGCTACGCCTGCTCCGTGGTA
GTGGACGGCGACACCAAGCACTGCGTCATCTACCGCACGGCCACCGGCTTCGGCTTCGCG
GAGCCCTACAACCTGTACGGGTCGCTGAAGGAGCTGGTGCTGCACTACCAGCACGCCTCG
CTGGTGCAGCACAACGACGCGCTCACCGTCACCCTGGCGCACCCAGTGCGCGCCCCGGGC
CCCGGCCCGCCGCCTGCCGCCCGCTGA
>OriGene 5' read for NM_005027 unedited
TAACCCCCGCCCCGTTGNCGCAAAGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAG
CAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGC
GAATTCGGACGAGGCAATGGCCCAGTGACCTGACACCACACCACCAACTCCCTCCCACCA
GCTGACGAATGGTGGACCCAGTGACGAGTGGCCCTTGTAAGGGTCATGGAATAATTTGAA
GCGAGGCATGAGCGGCCCCTGTGGTCGCCTGTGACTGCTGGAGATAGAGGTCCCAGCACC
CCAAGCCAACCCAGCGGACCCTCCCAGCCCTGCTTCAACCAATGGGGCCAGTGGGGCTCC
AAGCAGCCACCTAACCATCCAGACCCCACCCCACTCACGCGGCCATGGCGGGCCCTGAGG
GCTTCCAGTACCGCGCTCTGTACCCGTTCCGCCGGGAGCGGCCGGAGGACCTGGAGCTGC
TGCCCGGCGACGTGCTGGTAGTGAGCCGGGCGGCCTTGCAGGCGCTGGGCGTGGCCGAGG
GTGGCGAGCGCTGCCCACAGAGCGTGGGCTGGATGCCCGGCCTCAACGAGCGCACACGGC
AGCGAGGTGACTTNCCTGGCACCTATGTGGAGTTNCTGGGGCCCGTGGCCCTGGCCCGGC
CCGCCCTCGCCCACGGNNGCCCCGCCACTGCCCGCCAGGCCCCGTGATGGGGCCCCTGAG
CCAGGCCTACACTTCCCGACTTGCCCGACAGTTCTCCCCACTGATGTGGCTCCCCTCTTC
TGTGAAGCTGTTGAGGCCCATGAAGGACAGGGCTGGACAGCGAATCTCACTACGCCCGGA
CTGCCGCACGCGTACGACTGGTCCTGACGAGTGGATCGTGGGACACGCAGCCTGCCTGAC
GCATTAGAGCTTCTGCTGCACTGCCGCGCCGTCGGACCCCGAGCTCGCN
>OriGene 3' read for NM_005027 unedited
GAACTACTATGTACGTGGCCGCGTTCTATGATCGGTTTTTTTTTTTTTTTTTTGACGTTT
GATGTTTTATATCATATCAATAACAACGTACCGTACAAAACCTGCCTCCCAGCTCGTGGG
GCAGGCAGTGTGGTGGCCAAGGGCAGCGTATAAAACCAGGGCTCTTGTCCCAAAAGAGGA
GAGGAAAGAGGGTTTTGCAGTCAAGGAAAAACAGAATCAAAACCCAACATGATCGAAGAG
AAGCCCTGAATCTGCATCAGAGGGAGGGGCCGTGGGCAGTGTCGCAACTTGGCCACTGCG
GCGGCACCAGTACGGGGAGCTGTGATTCCTAAGAGGGGTTGGGGCCAGCTCACAAGTTTA
TTTATTTATTTTTTTGAGACGGAGGAGTCTCCCTCTGTTACCCAAGCTGGGAGTGCANTG
GCACGATCTCTGCTCACTGCAACCTCCATCTCCTGGGTTCAAGAGATTCTCACGCCTCAG
CCTCCCAAGTAGCTGGGATTACAGGCGGCCGCCACCACGCCCGGCTAATTTTTGTATTTT
AGTAGATGCGGGGTTTTGCCATTTTGGCCAAATTGGCCTTCAACTCCCGACCTTCAAAGA
TCCGCCCGTCTTGGCCTCCCCAAGTGCTGGGATTACAGGCATGAACCACCGTGCCTGGCC
TGCGAGTTTAATTTTTTTTTCGGGGTGGGGTGAACTTTTCTGCACCGGCCCCTTTGGGGG
GTAACCCGGTGGCGGGTTTTACCTTGGGGTTTGGAGGGGAATTTGGGTTCTGTGGGGCGG
GTCCCCCCCGGCCCCCATGGTACCGGCCCGGGTTTTTTGGAACCACAAAATTGAATTTCC
TTTCTGGCCCTGCCCCAGGTCTATGGGCTTAAAAATAAGGGGCCCCACA
Restriction Sites NotI-NotI     
ACCN NM_005027
Insert Size 3500 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005027.2, NP_005018.1
RefSeq Size 3953 bp
RefSeq ORF 2187 bp
Locus ID 5296
Cytogenetics 19p13.11
Domains RhoGAP, SH2, SH3
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Phosphatidylinositol signaling system, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, VEGF signaling pathway
Gene Summary 'Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]'
Transcript Variant: This variant (1) represents the protein-coding variant.

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.