KRIT1 (NM_004912) Human Untagged Clone

CAT#: SC117060

KRIT1 (untagged)-Human KRIT1, ankyrin repeat containing (KRIT1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: KRIT1
• Synonyms: CAM; CCM1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004912, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGAAATCCAGAAAACATAGAAGATGCATATGTTGCTGTTATTCGTCCAAAGAATACTGCCAGTCTCA
  ATTCTCGGGAATACAGAGCTAAGTCATATGAAATTTTGTTGCATGAAGTTCCCATTGAAGGACAGAAAAA
  AAAGAGAAAGAAAGTTTTATTGGAAACGAAACTTCAAGGCAACAGTGAAATAACACAAGGCATATTGGAT
  TACGTAGTAGAAACCACCAAACCAATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAA
  TGAAAAAATTTCCTCTGGATGGAGAGAAGATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGT
  CAAAGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATATTATGCGA
  GTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAATAGCCTTGGATAAGTGGT
  TAGATGAACGTCATGCACAATCTCACTTTATTCCAGCTTTATTCCGACCTTCTCCTCTTGAGCGGATAAA
  AACTAATGTCATAAATCCTGCATATGCTACTGAATCAGGTCAGACAGAAAACTCACTACATATGGGCTAT
  AGTGCACTAGAAATAAAGAGTAAAATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGT
  TTGGATCAGATCTTCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGC
  TCCAGACTACTCAAAAATCCAAATACCTAAACAGGAAAAATGGCAGAGAAGCATGAGCAGTGTCACAGAA
  GACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCGAAGCGCCTGTGAAGGAGATTCAGAATTAC
  TAAGCCGTCTTCTCAGTGAAAGATTTTCAGTCAACCAGTTAGATAGTGACCACTGGGCACCCATTCATTA
  TGCATGCTGGTATGGAAAAGTTGAGGCCACTCGCATATTGTTAGAGAAAGGAAAGTGCAATCCAAACCTT
  TTAAATGGACAACTTAGTTCTCCTCTTCATTTTGCTGCTGGAGGAGGACATGCTGAAATAGTACAGATTC
  TCCTAAACCACCCAGAAACGGATAGACATATAACAGACCAACAAGGAAGATCTCCATTAAATATTTGTGA
  AGAAAACAAACAAAACAACTGGGAAGAAGCTGCAAAATTGTTGAAGGAAGCAATTAACAAACCATATGAA
  AAAGTTCGAATATACAGAATGGATGGGTCATATCGTTCTGTTGAATTGAAGCATGGAAATAATACCACAG
  TGCAGCAGATAATGGAAGGAATGCGTCTCTCTCAAGAAACTCAGCAATATTTCACTATATGGATTTGTTC
  AGAAAACCTCAGCCTTCAACTCAAACCATATCATAAACCCTTGCAACATGTTCGTGACTGGCCAGAAATA
  CTTGCTGAATTGACTAATCTGGATCCTCAAAGGGAAACACCTCAGCTTTTTCTAAGAAGAGATGTGAGAC
  TTCCCTTGGAAGTTGAAAAACAGATTGAAGACCCACTAGCTATTCTTATTCTCTTTGATGAAGCCAGATA
  TAATTTATTGAAGGGCTTTTATACAGCTCCTGATGCTAAGCTGATAACATTGGCAAGTCTGCTTTTGCAA
  ATAGTCTATGGAAATTATGAGAGTAAAAAACACAAGCAAGGTTTCCTAAATGAAGAAAATCTAAAATCCA
  TCGTACCTGTTACCAAACTGAAAAGTAAGGCACCTCACTGGACAAATCGCATACTTCATGAATACAAGAA
  TCTCAGTACAAGTGAAGGTGTCAGTAAAGAAATGCATCACCTTCAGCGCATGTTCTTACAGAATTGCTGG
  GAAATTCCTACTTATGGAGCAGCATTTTTCACAGGACAGATATTTACAAAGGCAAGCCCCAGCAATCATA
  AAGTCATCCCTGTGTATGTAGGAGTGAATATAAAAGGACTTCATCTCCTCAACATGGAAACTAAGGCTTT
  ACTCATCAGTCTTAAGTATGGTTGTTTTATGTGGCAATTGGGAGATACTGATACTTGTTTTCAGATCCAT
  AGCATGGAAAATAAAATGAGCTTTATAGTACATACAAAACAGGCTGGTCTCGTGGTAAAACTGTTAATGA
  AGCTAAATGGACAGTTAATGCCCACTGAAAGAAATTCATGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004912 unedited
  GGTTCACCAATTTGTAATACGACCTCACTATAGGCGGCCCGCGAATCGGCACGAGGCCTC
  GTGCCGAATTCGGCACGAGGCACAAGGCATATTGGATTACGTAGTAGAAACCACCAAACC
  AATTTCTCCTGCAAACCAGGGTATCAGAGGAAAACGAGTTGTACTAATGAAAAAATTTCC
  TCTGGATGGAGAGAAGATGGGCAGAGAAGCATCATTATTTATTGTTCCATCAGTTGTCAA
  AGATAATACTAAATACACATATACCCCAGGATGCCCAATTTTTTACTGCTTACAAGATAT
  TATGCGAGTCTGTAGTGAATCCAGTACTCATTTTGCTACACTTACAGCAAGGATGTTAAT
  AGCCTTGGATAAGTGGTTAGATGAACGTCATGCACAATCTCACTTTATTCCAGCTTTATT
  CCGACCTTCTCCTCTTGAGCGGATAAAAACTAATGTCATAAATCCTGCATATGCTACTGA
  ATCAGGTCAGACAGAAAACTCACTACATATGGGCTATAGTGCACTAGAAATAAAGAGTAA
  AATGTTAGCCCTAGAGAAAGCAGATACCTGTATTTACAACCCTTTGTTTGGATCAGATCT
  TCAGTATACAAATCGGGTAGATAAAGTGGTAATAAATCCATACTTTGGTCTAGGAGCTCC
  AGACTACTCANAAATCCAAATACCTAAACAGGAAAAATGGCAGAGAAGCATGAGCAGTGT
  CACAGAAGACAAGGAACGACAGTGGGTAGATGATTTTCCTCTCCACCCGAGCGCCTGTGA
  ANGAGATTCAGAATTACTAAGCCGTCTTCTCAGTGAAAGATTTCAGTCAACCAGNTAGAT
  AGTGACCCACTGGCACCCATTCTTATGCATGCCTGTATGGAAAAAGTTGAGCCACTCGCA
  TATTGTTAGAGAAAGGAC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004912 unedited
  CGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTGTGT
  CACCCAGGCTAGCGTGCCGTGGTGCAATCTCGGCTCACTACAACCTCCACCTCCCGGGTT
  TAAGCGATCTCCCACCTTGGCCTCCCTAGTAGCTAGGATTATAGGCGCCCGCCACCACAC
  CCAGCTAATTTTTGCATTTCTGTAGAGACAGGGTTCCACCATGTTGGCACATCCTGGTAT
  TGAACTCCTGACTTCAGGTGATACCGACTGCCACAAACCCCATAAACCGCCGAAATTCCA
  CGAATGCCTTCTTCCCCCCCCTCCCTTATTCTTCCCCCGCCACCCAAACCCCCCCCCCAC
  CCCCGAGTTCTTCTACCTAATCCGCTTCCCAATTCTCCTCCCCCCTCTCCCCCCTCTCAC
  TCTTCCCACCCACACTCCTTCCCCCCCATCCCCCTACCCCCCTTTTTTCCCCCCACCCCA
  CTTACTCCCCCCACCCCCCCCTCTCCCCATTTTTCTCATTCTTCTCACTCCCCTTCACTT
  CCTTATCTCCAACCACTTCCCACCCCCCCCCTCCCTTCTACCCCCCCCCCCCCCACACAT
  ACCTCCCATCTTTATTTCTCTATCACTCCCCCCCCCTCCACCCTGCTGATAACCCACCAG
  TTTACTTCCCTACTCTCTCTTCTTCCTTTCCCCCCCCCTCCTCACCATTTTACTTCTCCC
  CTCCCCCCACTCCCTCCCACCCTTCTAATTCCTAAATCAACCCGAGTCCGCCGCGCCACC
  CCCCCTCTCCCTCCTTTCCCTTTTTCCCCACTTCACCCACTCCCCCCCATGACCTCCTAT
  CCTCCCCTCCCCCCCTTCCTCCTCCTTTACTCCCCGCACCCCAACCCCCATGCCCCCTCC
  CACCTCATACTCTCCTTTCTTCCCCCTCCCCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004912
• ORF Size: 2211 bp
• Insert Size: 2600
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_004912.3, NP_004903.2
• RefSeq Size: 4870
• RefSeq ORF: 2211
• Locus ID: 889
• Domains: B41, ANK
• Protein Families: Druggable Genome
• Gene Summary: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
  Transcript Variant: This variant (2) lacks the 5' exon but has an alternate segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.