FADD (NM_003824) Human Untagged Clone

CAT#: SC117739

FADD (untagged)-Human Fas (TNFRSF6)-associated via death domain (FADD)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FADD
• Synonyms: GIG3; MORT1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003824 edited
  GAATTCGGCACGAGGCGCTCTTGTCGATTTCCTGTAGTGAATCAGGCACCGGAGTGCAGG
  TTCGGGGGTGGAATCCTTGGGCCGCTGGGCAAGCGGCGAGACCTGGCCAGGGCCAGCGAG
  CCGAGGACAGAGGGCGCGCGGAGGGCCGGGCCGCAGCCCCGGCCGCTTGCAGACCCCGCC
  ATGGACCCGTTCCTGGTGCTGCTGCACTCGGTGTCGTCCAGCCTGTCGAGCAGCGAGCTG
  ACCGAGCTCAAGTTCCTATGCCTCGGGCGCGTGGGCAAGCGCAAGCTGGAGCGCGTGCAG
  AGCGGCCTAGACCTCTTCTCCATGCTGCTGGAGCAGAACGACCTGGAGCCCGGGCACACC
  GAGCTCCTGCGCGAGCTGCTCGCCTCCCTGCGGCGCCACGACCTGCTGCGGCGCGTCGAC
  GACTTCGAGGCGGGGGCGGCGGCCGGGGCCGCGCCTGGGGAAGAAGACCTGTGTGCAGCA
  TTTAACGTCATATGTGATAATGTGGGGAAAGATTGGAGAAGGCTGGCTCGTCAGCTCAAA
  GTCTCAGACACCAAGATCGACAGCATCGAGGACAGATACCCCCGCAACCTGACAGAGCGT
  GTGCGGGAGTCACTGAGAATCTGGAAGAACACAGAGAAGGAGAACGCAACAGTGGCCCAC
  CTGGTGGGGGCTCTCAGGTCCTGCCAGATGAACCTGGTGGCTGACCTGGTACAAGAGGTT
  CAGCAGGCCCGTGACCTCCAGAACAGGAGTGGGGCCATGTCCCCGATGTCATGGAACTCA
  GACGCATCTACCTCCGAAGCGTCCTGATGGGCCGCTGCTTTGCGCTGGTGGACCACAGGC
  ATCTACACAGCCTGGACTTTGGTTCTCTCCAGGAAGGTAGCCCAGCACTGTGAAGACCCA
  GCAGGAAGCCAGGCTGAGTGAGCCACAGACCACCTGCTTCTGAACTCAAGCTGCGTTTAT
  TAATGCCTCTCCCGCACCAGGCCGGGCTTGGGCCCTGCACAGATATTTCCATTTCTTCCT
  CACTATGACACTGAGCAAGATCTTGTCTCCACTAAATGAGCTCCTGCGGGAGTAGTTGGA
  AAGTTGGAACCGTGTCCAGCACAGAAGGAATCTGTGCAGATGAGCAGTCACACTGTTACT
  CCACAGCGGAGGAGACCAGCTCAGAGGCCCAGGAATCGGAGCGAAGCAGAGAGGTGGAGA
  ACTGGGATTTGAACCCCCGCCATCCTTCACCAGAGCCCATGCTCAACCACTGTGGCGTTC
  TGCTGCCCCTGCAGTTGGCAGAAAGGATGTTTTGTCCCATTTCCTTGGAGGCCACCGGGA
  CAGACCTGGACACTAGGGTCAGGCGGGGTGCTGTTGTGGTGGGGAGAGGCATGGCTGGGG
  TGGGGGTGGGGAGACCTGGTTGGCCGTGGTCCAGCTCTTGGCCCCTGTGTGAGTTGAGTC
  TCCTCTCTGAGACTGCTAAGTAGGGGCAGTGATGGTTGCCAGGACGAATTGAGATAATAT
  CTGTGAGGTGCTGATGAGTGATTGACACACAGCACTCTCTAAATCTTCCTTGTGAGGATT
  ATGGGTCCTGCAATTCTACAGTTTCTTACTGTTTTGTATCAAAATCACTATCTTTCTGAT
  AACAGAATTGCCAAGGCAGCGGGATCTCGTATCTTTAAAAAGCAGTCCTCTTATTCCTAA
  GGTAATCCTATTAAAACACAGCTTTACAACTTCAAAAAAAAAAAAAAAAAAAAAAAAAAA
  CTCGAC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003824 unedited
  TTCAAAATTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGCGCTCTT
  GTCGATTTCCTGTAGTGAATCAGGCACCGGAGTGCAGGTTCGGGGGTGGAATCCTTGGGC
  CGCTGGGCAAGCGGCGAGACCTGGCCAGGGCCAGCGAGCCGAGGACAGAGGGCGCGCGGA
  GGGCCGGGCCGCAGCCCCGGCCGCTTGCAGACCCCGCCATGGACCCGTTCCTGGTGCTGC
  TGCACTCGGTGTCGTCCAGCCTGTCGAGCAGCGAGCTGACCGAGCTCAAGTTCCTATGCC
  TCGGGCGCGTGGGCAAGCGCAAGCTGGAGCGCGTGCAGAGCGGCCTAGACCTCTTCTCCA
  TGCTGCTGGAGCAGAACGACCTGGAGCCCGGGCACACCGAGCTCCTGCGCGAGCTGCTCG
  CCTCCCTGCGGCGCCACGACCTGCTGCGGCGCGTCGACGACTTCGAGGCGGGGGGCGGCG
  GCCGGNGCCGCGCCTGGGGAAGAAGACCTGTGTGCAGCATTTAACGTCATATGTGATAAT
  GTGGGGAAAGATTGGAGAAGGCTGGCTCGTCAGCTCAAAGTCTCAGACACCAAGATCGAC
  AGCATCGAGGACAGATACCCCCGCAACCTGACAGAGCGTGTGCGGGGAGTCACTGAGAAT
  CTGGAAGAACACAGAGAAGGAGAACGCAACAGTGGCCACCTGGGTGGGGGCTTCTCAGGT
  CCTGCCAGATGAACCTGGNTGGCTGACCTGGACCCAAGAGGTTCCAGCAGGGCCCGTGAC
  CTCAGACAGGAGGATTGGGGCCATGTCCCCCGATGTCATGGGACTCAGACGCATCACCTC
  CCAACGCCCCTGATGGGCCGCTGCTTTGGCCCTGGTGGACCACAGCATCTACCAGNCGGC
  ATTTTTGGTCTCTCCCAGGAAGGGTACCCACCCTTGGGAAGACCCAGCAGAGCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_003824 unedited
  GACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTGAAGTTG
  TAAAGCTGTGTTTTAATAGGATTACCTTAGGAATAAGAGGACTGCTTTTTAAAGATACGA
  GATCCCGCTGCCTTGGCAATTCTGTTATCAGAAAGATAGTGATTTTGATACAAAACAGTA
  AGAAACTGTAGAATTGCAGGACCCATAATCCTCACAAGGAAGATTTAAAGAGTGCTGTGT
  GTCAATCACTCATCAGCACCTCACAGATATTATCTCAATTCGTCCTGGCAACCATCACTG
  CCCCTACTTAGCAGTCTCAGAGAGGAGACTCAACTCACACAGGGGCCAAGAGCTGGACCA
  CGGCCAACCAGGTCTCCCCACCCCCACCCCAGCCATGCCTTTCCCCACCACAACAGCACC
  CCGCCTGACCCTAGTGTCCAGGTCTGTCCCGGTGGCCTCCAAGGAAATGGGACAAAACAT
  CCTTTCTGCCAACTGCAGGGGCAGCAGAACGCCACAGTGGTTGAGCATGGGCTCTGGTGA
  AGGATGGCGGGGGTTCAAATCCCAGTTCTCCACCTCTCTGCTTCGCTCCGATTCCTGGGC
  CTCTGAGCTGGTCTCCTCCGCTGTGGAGTAACAGTGTGACTGCTTATCTGCACAGATTCC
  CTTTGTGCTGGACACGGTTCCAACTTTCCAACTACTCCCGCCAGAGCTTATTTATTGGAA
  ACCAGATCTTGGCTCAATGGCTTAGTGAGGGAGAAATGGAAATTTTTGTGCAGGGCCCAA
  CCCCGGCCTGGTGCGGGGAAGGGCTTTTATAAACCCAGCTTGATTTCAAAACAGGGGGGC
  TGTGGCTCACTTACACCGGCTTTCTGCTGGGGCTTACAAGGGCTGGGCTCCTTCTGGAAA
  AAACCCAATCCCAGCT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003824
• ORF Size: 627 bp
• Insert Size: 1970
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003824.2, NP_003815.1
• RefSeq Size: 1873
• RefSeq ORF: 627
• Locus ID: 8772
• Domains: DEATH, DED
• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
• Gene Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]