LIFR (NM_002310) Human Untagged Clone

CAT#: SC118708

LIFR (untagged)-Human leukemia inhibitory factor receptor alpha (LIFR), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LIFR
• Synonyms: CD118; LIF-R; SJS2; STWS; SWS
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118708 sequence for NM_002310 edited (data generated by NextGen Sequencing)
  ATGATGGATATTTACGTATGTTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATG
  AGGACTGCTTCAAATTTCCAGTGGCTGTTATCAACATTTATTCTTCTATATCTAATGAAT
  CAAGTAAATAGCCAGAAAAAGGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTG
  CAAGTGTGGAACTGTTCTTGGAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAA
  GTTTGCATTGAAAACAGGTCCCGTTCTTGTTATCAGTTGGAGAAAACCAGTATTAAAATT
  CCAGCTCTTTCACATGGTGATTATGAAATAACAATAAATTCTCTACATGATTTTGGAAGT
  TCTACAAGTAAATTCACACTAAATGAACAAAACGTTTCCTTAATTCCAGATACTCCAGAG
  ATCTTGAATTTGTCTGCTGATTTCTCAACCTCTACATTATACCTAAAGTGGAACGACAGG
  GGTTCAGTTTTTCCACACCGCTCAAATGTTATCTGGGAAATTAAAGTTCTACGTAAAGAG
  AGTATGGAGCTCGTAAAATTAGTGACCCACAACACAACTCTGAATGGCAAAGATACACTT
  CATCACTGGAGTTGGGCCTCAGATATGCCCTTGGAATGTGCCATTCATTTTGTGGAAATT
  AGATGCTACATTGACAATCTTCATTTTTCTGGTCTCGAAGAGTGGAGTGACTGGAGCCCT
  GTGAAGAACATTTCTTGGATACCTGATTCTCAGACTAAGGTTTTTCCTCAAGATAAAGTG
  ATACTTGTAGGCTCAGACATAACATTTTGTTGTGTGAGTCAAGAAAAAGTGTTATCAGCA
  CTGATTGGCCATACAAACTGCCCCTTGATCCATCTTGATGGGGAAAATGTTGCAATCAAG
  ATTCGTAATATTTCTGTTTCTGCAAGTAGTGGAACAAATGTAGTTTTTACAACCGAAGAT
  AACATATTTGGAACCGTTATTTTTGCTGGATATCCACCAGATACTCCTCAACAACTGAAT
  TGTGAGACACATGATTTAAAAGAAATTATATGTAGTTGGAATCCAGGAAGGGTGACAGCG
  TTGGTGGGCCCACGTGCTACAAGCTACACTTTAGTTGAAAGTTTTTCAGGAAAATATGTT
  AGACTTAAAAGAGCTGAAGCACCTACAAACGAAAGCTATCAATTATTATTTCAAATGCTT
  CCAAATCAAGAAATATATAATTTTACTTTGAATGCTCACAATCCGCTGGGTCGATCACAA
  TCAACAATTTTAGTTAATATAACTGAAAAAGTTTATCCCCATACTCCTACTTCATTCAAA
  GTGAAGGATATTAATTCAACAGCTGTTAAACTTTCTTGGCATTTACCAGGCAACTTTGCA
  AAGATTAATTTTTTATGTGAAATTGAAATTAAGAAATCTAATTCAGTACAAGAGCAGCGG
  AATGTCACAATCAAAGGAGTAGAAAATTCAAGTTATCTTGTTGCTCTGGACAAGTTAAAT
  CCATACACTCTATATACTTTTCGGATTCGTTGTTCTACTGAAACTTTCTGGAAATGGAGC
  AAATGGAGCAATAAAAAACAACATTTAACAACAGAAGCCAGTCCTTCAAAGGGGCCTGAT
  ACTTGGAGAGAGTGGAGTTCTGATGGAAAAAATTTAATAATCTATTGGAAGCCTTTACCC
  ATTAATGAAGCTAATGGAAAAATACTTTCCTACAATGTATCGTGTTCATCAAATGAGGAA
  ACACAGTCCCTTTCTGAAATCCCTGATCCTCAGCACAAAGCAGAGATACGACTTGATAAG
  AATGACTACATCATCAGCGTAGTGGCTAAAAATTCTGTGGGCTCATCACCACCTTCCAAA
  ATAGCGAGTATGGAAATTCCAAATGATGATCTCAAAATAGAACAAGTTGTTGGGATGGGA
  AAGGGGATTCTCCTCACCTGGCATTACGACCCCAACATGACTTGCGACTACGTCATTAAG
  TGGTGTAACTCGTCTCGGTCGGAACCATGCCTTATGGACTGGAGAAAAGTTCCCTCAAAC
  AGCACTGAAACTGTAATAGAATCTGATGAGTTTCGACCAGGTATAAGATATAATTTTTTC
  CTGTATGGATGCAGAAATCAAGGATATCAATTATTACGCTCCATGATTGGATATATAGAA
  GAATTGGCTCCCATTGTTGCACCAAATTTTACTGTTGAGGATACTTCTGCAGATTCGATA
  TTAGTAAAATGGGAAGACATTCCTGTGGAAGAACTTAGAGGCTTTTTAAGAGGATATTTG
  TTTTACTTTGGAAAAGGAGAAAGAGACACATCTAAGATGAGGGTTTTAGAATCAGGTCGT
  TCTGACATAAAAGTTAAGAATATTACTGACATATCCCAGAAGACACTGAGAATTGCTGAT
  CTTCAAGGTAAAACAAGTTACCACCTGGTCTTGCGAGCCTATACAGATGGTGGAGTGGGC
  CCGGAGAAGAGTATGTATGTGGTGACAAAGGAAAATTCTGTGGGATTAATTATTGCCATT
  CTCATCCCAGTGGCAGTGGCTGTCATTGTTGGAGTGGTGACAAGTATCCTTTGCTATCGG
  AAACGAGAATGGATTAAAGAAACCTTCTACCCTGATATTCCAAATCCAGAAAACTGTAAA
  GCATTACAGTTTCAAAAGAGTGTCTGTGAGGGAAGCAGTGCTCTTAAAACATTGGAAATG
  AATCCTTGTACCCCAAATAATGTTGAGGTTCTGGAAACTCGATCAGCATTTCCTAAAATA
  GAAGATACAGAAATAATTTCCCCAGTAGCTGAGCGTCCTGAAGATCGCTCTGATGCAGAG
  CCTGAAAACCATGTGGTTGTGTCCTATTGTCCACCCATCATTGAGGAAGAAATACCAAAC
  CCAGCCGCAGATGAAGCTGGAGGGACTGCACAGGTTATTTACATTGATGTTCAGTCGATG
  TATCAGCCTCAAGCAAAACCAGAAGAAGAACAAGAAAATGACCCTGTAGGAGGGGCAGGC
  TATAAGCCACAGATGCACCTCCCCATTAATTCTACTGTGGAAGATATAGCTGCAGAAGAG
  GACTTAGATAAAACTGCGGGTTACAGACCTCAGGCCAATGTAAATACATGGAATTTAGTG
  TCTCCAGACTCTCCTAGATCCATAGACAGCAACAGTGAGATTGTCTCATTTGGAAGTCCA
  TGCTCCATTAATTCCCGACAATTTTTGATTCCTCCTAAAGATGAAGACTCTCCTAAATCT
  AATGGAGGAGGGTGGTCCTTTACAAACTTTTTTCAGAACAAACCAAACGATTAA
  
  Clone variation with respect to NM_002310.5
  1732 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002310 unedited
  NTTGTACGAATTTTGGTATACGACTCACTTATAGGGCGGCCGCGAATCGGCACCANAATA
  AGCCCACCCCGCCTCCGAGGCAAGACTAGATGGCTCCAGGATACTCTCGGCGCGCCCGCT
  GGCCATCTCGGGCAGGGGAGCCCCACACCCGGCAGGAGGACCAGGACGCGAGCGGCGGCG
  CCTCGGCCCTGGGCTGTTTAGGACTGACTGCATTGCACAGATGATGGATATTTACGTATG
  TTTGAAACGACCATCCTGGATGGTGGACAATAAAAGAATGAGGACTGCTTCAAATTTCCA
  GTGGCTGTTATCAACATTTATTCTTCTATATCTAATGAATCAAGTAAATAGCCAGAAAAA
  GGGGGCTCCTCATGATTTGAAGTGTGTAACTAACAATTTGCAAGTGTGGAACTGTTCTTG
  GAAAGCACCCTCTGGAACAGGCCGTGGTACTGATTATGAAGTTTGCATTGAAAACAGGTC
  CCGTTCTTGTTATCAGTTGGAGAAAACCAGTATTAAAATTCCAGCTCTTTCACATGGTGA
  TTATGAAATAACAATAAATTCTCTACATGATTNTGGAAGTTCTACAAGTAAATTCACACT
  AAATGAACAAAACGTTTCCTTTATTCCAGATACTCCAGAGATCTTGAATTTGTCTGCTGA
  TTTCTCAACCTCTACATTATACCCTAAAGTGGAACGACAGGGGGTTCAGTTTTTCCACAC
  CGCTCACATGGTATCTGGGAAAATAAAGTTCTACGTAAAGAGAGAATGGAGCTCGAAAAA
  TAGGGACCCCCACACAACTCTGAATGGCAAAGATCACTTATCACTGTAGGTGGGCCCTAG
  AATGCCCTTGGAAGGTGCCATCATTTTGTGAAATTAGAGCCTACTTGACATCCTCTTTTT
  CTGGCCTCGAAAAGGCAGGACCGGAGCCTGTGAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002310 unedited
  AGTTTGGCTCTGTAGGCTATTTTTTNCTTACTGGACATTTCTATGAACTTTATATAGTTT
  TAATATACTATGTATGTACAAAATGAATTGCATTTCATTCCAAATTTCCACANATCATAA
  AGCTCAGAATTTAGCTGAATCCTAGCAGTTAAAATCAGGATTCATACACAGAGAACCTAA
  ATAGATTTTGTCACTTGTCACTCTGGCTTTTTTCCACAACATGGTTTTTAAAAAGATACA
  ATATGAGCTTCAAAAAAAATTAATTGATCCATTATTTGCAAATACATTACAGAATCTCAG
  ATGACAAAAAACAAACAAACAACCAAAAACAACAAACAAAAAAGACATATCTTATTCGGA
  CACTTAAAATTTTCAAGTACTTTTGCCTTAAATATGAAAAGGTAAAATACATAGGCAACC
  TGAGGGCAGGGAAAATACAAGATACACTTTTTAGTTTTTCCTTCTGCTTTTCCAAGAACC
  ACAATCACTCCAGACATCGCTTATGAGAAACAAGGGTGGGCAGAGGATGCTGTGCTGAAG
  GCAATCAATTCTGCACAGCTCACCAAGCAATTGCTGCACCTGCAACACAGGTATGCCCAT
  GGATTCAGATCAGTTTATGACCGTTTACTAAGAAAACAGCCCCTTGGGTAACTGGGTCCT
  GGTAGAAGCATTCCCTCTTTAGTTCCATATTCAAAAAGGGGCAGGCCTGGCCCCCAATAA
  GGGGGCCTGGCGGAAAGACCCCTGGGGTGGGGAGGACCCTCCACCAGAAGGTGGTCAAAG
  ATCCCCCCTGCCCCGGTNAGCCCAACCCAATGGGCTGGGGCTCCCTTAGGGGGGAGCGGA
  CATCCATTCTGACCTTCTTGGGGCGGCTTCCCCCTGTCTTACCATTGGTTCAACCAACCC
  TCCTCGCCTACGCGGGCGCCCGGGACTCCCCGCGTTGATGAACCACCTCCGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_002310
• Insert Size: 5550 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002310.3, NP_002301.1
• RefSeq Size: 10099 bp
• RefSeq ORF: 3294 bp
• Locus ID: 3977
• Cytogenetics: 5p13.1
• Domains: FN3
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Gene Summary: 'This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2018]'
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.