IGF1 (NM_000618) Human Untagged Clone

CAT#: SC119792

IGF1 (untagged)-Human insulin-like growth factor 1 (somatomedin C) (IGF1), transcript variant 4


  "NM_000618" in other vectors (6)

Reconstitution Protocol

USD 420.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IGF1
Synonyms IGF; IGF-I; IGFI; MGF
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_000618 edited
ATGGGAAAAATCAGCAGTCTTCCAACCCAATTATTTAAGTGCTGCTTTTGTGATTTCTTG
AAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCTGGCGCTGTGCCTGCTC
ACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGGGGCTGAGCTGGTGGAT
GCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAAGCCCACAGGGTATGGC
TCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTGCTGCTTCCGGAGCTGT
GATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGCCAAGTCAGCTCGCTCT
GTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGAAGTACATTTGAAGAAC
GCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAG
>OriGene 5' read for NM_000618 unedited
GGGGATCAGGATTTTGTATACGACTCTACTATAGGCGGCCGCGCAATTCGCACCAGCAGA
CTTTGTACTTCATAACAATGGGAAAAACAGCAGTCTTCCAACCCAATTATTTAAGTGCTG
CTTTTGTGATTTCTTGAAGGTGAAGATGCACACCATGTCCTCCTCGCATCTCTTCTACCT
GGCGCTGTGCCTGCTCACCTTCACCAGCTCTGCCACGGCTGGACCGGAGACGCTCTGCGG
GGCTGAGCTGGTGGATGCTCTTCAGTTCGTGTGTGGAGACAGGGGCTTTTATTTCAACAA
GCCCACAGGGTATGGCTCCAGCAGTCGGAGGGCGCCTCAGACAGGCATCGTGGATGAGTG
CTGCTTCCGGAGCTGTGATCTAAGGAGGCTGGAGATGTATTGCGCACCCCTCAAGCCTGC
CAAGTCAGCTCGCTCTGTCCGTGCCCAGCGCCACACCGACATGCCCAAGACCCAGAAGGA
AGTACATTTGAAGAACGCAAGTAGAGGGAGTGCAGGAAACAAGAACTACAGGATGTAGGA
AGACCCTCCTGAGGAGTGAAGAGTGACATGCCACCGCAGGATCCTTTGCTCTGCACGAGT
TACCTGTTAAACTTTGGAACACCTACCAAAAAATAAGTTTGATAACATTTAAAAGATGGG
CGTTTCCCCCAATGAAATACACAAGTAAACATTCCAACATTGTCTTTAGGAGTGATTTGC
ACCTTGCAAAAATGGTCCTGGAGTTGGTAGATTGCTGTTGATCTTTTATCAATAATGTTC
TATAGAAAAGAAAAAAAAATATATATATATATATATCCTAGTCCCTGCCTCTCAAGAGCC
ACNATGCATGGGTGTTGTATAGATCCAGTTGCACTAAATTCCTCTCTGAAATCTGGCTGC
TGGAGCCATCATTCAGCACCTTGT
>OriGene 3' read for NM_000618 unedited
CCCCCCGGTCCCGCTGTGTCTCCCTTCACTCCCGCCGNTCCGCCTATGCACCGCGGNCCG
CNATCCTACGACCGAGTTCTTTTTTTTTTTTTTTTAGTCAAGTACTTTCTTAAAGAAACA
TAGCACCACATTGGCATAGCTGGCCAAACAATAAATGGGAAAGCAAAATGTGCTACATCT
TTTATTCTAAGCCTTCTCCCAAGTGCATAAAATAGTACCAGAACCCCTGGAGCCACAGAG
CCTGATATGGTTTTATCTACACAAACATTGACGCTTCACGGAGAGGAAGGATTCTCACGG
GCGGACCGGCCTCTCCGTTCCGCTCGTCCCGCCCTTTAATAAAACTTTCAAGGAAGTGAC
CTCTTTTCACTACCCCATTGGATTCTTACGCCGAATGTGTGTGCGTGCCGCGTGCGTGTG
TGTGTGTGTGCGCTCCTTCTCCATACCCTACTTTCCCTTTATCCACCTTTTCCTAATCTC
ACCCTTTAATTCCACCCCCCGTCCCCTTTATCCCCTATCCACACCCCCCTTTTTACTAAT
TCCTCCCCCCCCTCCCATAAATCTTTTCCCCACCCTTCTTCGTCCCTTTCTCTCTCTACT
ACACCCGCCACCTCCCCCATCCCCACCCTTATTTTCTACCATATATACTTACCCCAATCC
CATCTTTCNTCTCCCCCCCCCCACCCCCCCCCTCCCCATTCCCCCCCCGTCCTCTACCCC
CCACATCTTCCTTCCCCCACCCCCGCCCTCTCCCCCCGTTTCTCCGCTACCACACTTTTA
TATCCCATCTGTACTTCCCCACCACCCTCTCTTACCCGCCTTCGTCTTCTTTCCCCAACC
CTTCCCTTCTCCCCTTCTTTTTCATTTATATTTTTATGTATCCTCTCTCTACCTTCCCCC
CCACCTCATCTCTTTTTACCCATTTCCCCGTTGTTGTCACCCCATCCCCTACACGTCTTT
AGTTTGTTTGTCCTCCCCTCCGTCCATCTTTATCCACCAACCCCCCCCCGTGCTTTACCC
CCCCGTCTCCACCCAT
Restriction Sites NotI-NotI     
ACCN NM_000618
Insert Size 4230 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000618.2, NP_000609.1
RefSeq Size 7260 bp
RefSeq ORF 462 bp
Locus ID 3479
Cytogenetics 12q23.2
Domains IlGF
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Dilated cardiomyopathy, Focal adhesion, Glioma, Hypertrophic cardiomyopathy (HCM), Long-term depression, Melanoma, mTOR signaling pathway, Oocyte meiosis, p53 signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
Gene Summary 'The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]'
Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 1, resulting in a protein (isoform 4) with a novel C-terminus, compared to isoform 1. This isoform is also known as IA. Sequence Note: This RefSeq was created from transcript and genomic sequence because transcript sequence consistent with the reference assembly was not available for all regions of the RefSeq transcript. The extent of this transcript is supported by transcript alignments.

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