ADAMTS3 (NM_014243) Human Untagged Clone

CAT#: SC120706

ADAMTS3 (untagged)-Human ADAM metallopeptidase with thrombospondin type 1 motif, 3 (ADAMTS3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAMTS3
• Synonyms: ADAMTS-4; HKLLS3
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC120706 sequence for NM_014243 edited (data generated by NextGen Sequencing)
  ATGGTTCTCCTGTCACTTTGGTTGATAGCAGCCGCTCTGGTAGAGGTTAGGACTTCAGCT
  GATGGACAAGCTGGTAATGAAGAAATGGTGCAAATAGATTTACCAATAAAGAGATATAGA
  GAGTATGAGCTGGTGACTCCAGTCAGCACAAATCTAGAAGGACGCTATCTCTCCCATACT
  CTTTCTGCGAGTCACAAAAAGAGGTCAGCGAGGGACGTGTCTTCCAACCCTGAGCAGTTG
  TTCTTTAACATCACGGCATTTGGAAAAGATTTTCATCTGCGACTAAAGCCCAACACTCAA
  CTAGTAGCTCCTGGGGCTGTTGTGGAGTGGCATGAGACATCTCTGGTGCCTGGGAATATA
  ACCGATCCCATTAACAACCATCAACCAGGAAGTGCTACGTATAGAATCCGGAAAACAGAG
  CCTTTGCAGACTAACTGTGCTTATGTTGGTGACATCGTGGACATTCCAGGAACCTCTGTT
  GCCATCAGCAACTGTGATGGTCTGGCTGGAATGATAAAAAGTGATAATGAAGAGTATTTC
  ATTGAACCCTTGGAAAGAGGTAAACAGATGGAGGAAGAAAAAGGAAGGATTCATGTTGTC
  TACAAGAGATCAGCTGTAGAACAGGCTCCCATAGACATGTCCAAAGACTTCCACTACAGA
  GAGTCGGACCTGGAAGGCCTTGATGATCTAGGTACTGTTTATGGCAACATCCACCAGCAG
  CTGAATGAAACAATGAGACGCCGCAGACACGCGGGAGAAAACGATTACAATATCGAGGTA
  CTGCTGGGAGTGGATGACTCTGTGGTCCGTTTCCATGGCAAAGAGCACGTCCAAAACTAC
  CTCCTGACCCTAATGAACATTGTGAATGAAATTTACCATGATGAGTCCCTCGGAGTGCAT
  ATAAATGTGGTCCTGGTGCGCATGATAATGCTGGGATATGCAAAGTCCATCAGCCTCATA
  GAAAGGGGAAACCCATCCAGAAGCTTGGAGAATGTGTGTCGCTGGGCGTCCCAACAGCAA
  AGATCTGATCTCAACCACTCTGAACACCATGACCATGCAATTTTTTTAACCAGGCAAGAC
  TTTGGACCTGCTGGAATGCAAGGATATGCTCCAGTCACCGGCATGTGTCATCCAGTGAGA
  AGTTGTACCCTGAATCATGAGGATGGTTTTTCATCTGCTTTTGTAGTAGCCCATGAAACG
  GGCCATGTGTTGGGAATGGAGCATGATGGACAAGGCAACAGGTGTGGTGATGAGACTGCT
  ATGGGAAGTGTCATGGCTCCCTTGGTACAAGCAGCATTCCATCGTTACCACTGGTCCCGA
  TGCAGTGGTCAAGAACTGAAAAGATATATCCATTCCTATGACTGTCTCCTTGATGACCCT
  TTTGATCATGATTGGCCTAAACTCCCAGAACTTCCTGGAATCAATTATTCTATGGATGAG
  CAATGTCGTTTTGATTTTGGTGTTGGCTATAAAATGTGCACCGCGTTCCGAACCTTTGAC
  CCATGTAAACAGCTGTGGTGTAGCCATCCTGATAATCCCTACTTTTGTAAGACTAAAAAG
  GGACCTCCACTTGATGGGACTGAATGTGCTGCTGGAAAATGGTGCTATAAGGGTCATTGC
  ATGTGGAAGAATGCTAATCAGCAAAAACAAGATGGCAATTGGGGGTCATGGACTAAATTT
  GGCTCCTGTTCTCGGACATGTGGAACTGGTGTTCGTTTCAGAACACGCCAGTGCAATAAT
  CCCATGCCCATCAATGGTGGTCAGGATTGTCCTGGTGTTAATTTTGAGTACCAGCTTTGT
  AACACAGAAGAATGCCAAAAACACTTTGAGGACTTCAGAGCACAGCAGTGTCAGCAGCGA
  AACTCCCACTTTGAATACCAGAATACCAAACACCACTGGTTGCCATATGAACATCCTGAC
  CCCAAGAAAAGATGCCACCTTTACTGTCAGTCCAAGGAGACTGGAGATGTTGCTTACATG
  AAACAACTGGTGCATGATGGAACGCACTGTTCTTACAAAGATCCATATAGCATATGTGTG
  CGAGGAGAGTGTGTGAAAGTGGGCTGTGATAAAGAAATTGGTTCTAATAAGGTTGAGGAT
  AAGTGTGGTGTCTGTGGAGGAGATAATTCCCACTGCCGAACCGTGAAGGGGACATTTACC
  AGAACTCCCAGGAAGCTTGGGTACCTTAAGATGTTTGATATACCCCCTGGGGCTAGACAT
  GTGTTAATCCAAGAAGACGAGGCTTCTCCTCATATTCTTGCTATTAAGAACCAGGCTACA
  GGCCATTATATTTTAAATGGCAAAGGGGAGGAAGCCAAGTCGCGGACCTTCATAGATCTT
  GGTGTGGAGTGGGATTATAACATTGAAGATGACATTGAAAGTCTTCACACCGATGGACCT
  TTACATGATCCTGTTATTGTTTTGATTATACCTCAAGAAAATGATACCCGCTCTAGCCTG
  ACATATAAGTACATCATCCATGAAGACTCTGTACCTACAATCAACAGCAACAATGTCATC
  CAGGAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAGTGTTCCAAACCC
  TGTGGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATG
  GTCCATCGCAGCTTCTGTGAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAAT
  ATTCAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACACTGCACCAAAACC
  TGTGGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGC
  ACCAACCGCTCTGTGCACAGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCC
  TGTAACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGTGAGTGTTCAGTG
  ACCTGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGAT
  GGTGAAAAGCCTGAGTCGGTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGT
  TTGGGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATACTGCTCCATACCA
  GGTTATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCA
  TACCTTCTAGAAGCTGCTGAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCT
  AGATCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACCCCTGCAAAGAAG
  ATGTCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCA
  AACAGTAAACCTGATGGTGCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAG
  ACTGTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTCCACCTCAGTTCA
  GCTTCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCT
  CAGGCAAGAACCTCAAAGAAAGATGGAAAGATCATTGACAACAGACGTCCGACAAGATCA
  TCCACCTTAGAAAGATGA
  
  Clone variation with respect to NM_014243.2
  413 g=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014243 unedited
  AACTTTTGTATACGACTACTATAGGGCGGCCGCGAATTCGCACGAGGCTTTGCCCAGTAG
  TTGGAAAGTGAACTCGACTCGTGATGGTTCTCCTGTCACTTTGGTTGATAGCAGCCGCTC
  TGGTAGAGGTTAGGACTTCAGCTGATGGACAAGCTGGTAATGAAGAAATGGTGCAAATAG
  ATTTACCAATAAAGAGATATAGAGAGTATGAGCTGGTGACTCCAGTCAGCACAAATCTAG
  AAGGACGCTATCTCTCCCATACTCTTTCTGCGAGTCACAAAAAGAGGTCAGCGAGGGACG
  TGTCTTCCAACCCTGAGCAGTTGTTCTTTAACATCACGGCATTTGGAAAAGATTTTCATC
  TGCGACTAAAGCCCAACACTCAACTAGTAGCTCCTGGGGCTGTTGTGGAGTGGCATGAGA
  CATCTCTGGTGCCTGGGAATATAACCGATCCCATTAACAACCATCAACCAGGAAGTGCTA
  CGTATAGAATCCGGAAAACAGAGCCTTTGCAGACTAACTGTGCTTATGTTGGTGACATCG
  TGGACATTCCAGGAACCTCTGTTGCCATCAGCAACTGTGATGGTCTGGCTGGAATGATAA
  AAAGTGATAATGAAGAGTATTTCATTGAACCCTTGGAAAGAGGTAAACAGATGGAGGAAG
  AAAAGGAAGGATTCATGTTGTCTACAAGAGATCAGCTGTAGAACAGGCTCCCATAGACAT
  GTGCAAAGACTTNCACTACAGAGAGTCGGACCTGGNAAGCCTTGATGATCTANGTACTGG
  TTATGGGCACATCCACCAGCAGCTGAATGAAACAATGAGACGCCGCAGACACGCGGGAGA
  AAACGATTACACTATCGGAGTACTGCTGGGAGTGGATGACTCTGTGGTCCGTTNCCATGG
  GCAAGACACGTTCAAACTACCTTCTGACCTTATTGAACTTGTGAATGAAATTACC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_014243 unedited
  AGCTCTGGANCGGCGGCCGCAATCTACAATCGAGTTTTTTTTTTTTTTTTTTATATTTTG
  TTAACATTTTTATTGGTACGTGCTCTCAGTACAACAAACAGCATCAGTAGTGTACACTTT
  GATAAAAAGGAATTTTTAGCTTAGTAGAAAAGAAAGCCCAAAGGTCAGAAGTATAATGAA
  TATGTACATCTTTATGGAAACTGTTTGTGTGACCATCTTTATCTTCCCCTGTGGATGAGA
  TGTATGCACACACAAGTAAACTAGAGAGAATTTTATTCTATGGGAATTTTTAGGAAAAAA
  AAAAAGACTTAAGGCTTAGGGATTGTTTTACTATCTGGAATTTGCCTAATTTGACCTTCA
  AAGTTCTTGCACAAAGTAGCAGCAATTCTTTAGAGGTATAGAGTCAATAGTTTAAGCTGT
  TAGTTTACAACGATTAAAATGCAAAAGTTCTTGCACATTCTGTGCTTTGAGAGGTTAATT
  CATCTACATTTTAGTTTGTATAATATATTTTTAGACAGCTCAGGTACTGACCTCAAAATC
  ATTATGCTGATATCACTATCTCCTCTCATGTACATGTAATTCATGATGCACTTATCTCTT
  TCAAAACTTTTAAAAATGTTTCTAATTCACAATTTCATTGAACAGCTAGCTGAGTCCATA
  CAATTTAATGTTTCCTTGAAGGGAAACAAGTCATCAACTTAATATNAACTACTAAAAATG
  CACGATGTTTGCATAACATCAAATTTGGTCAGTTTTAACTTTTGAGTTGGCTGCACCATT
  TGGCTAAAGGTCTCCATGCACAGAAAAAGCTGCATCTCTATTATGCTCTCTACTCCCCAA
  AATGTATCGTCTCACGGTCCTTTTACCCTTATAATCTCTCCCGAAACAAATCACTTAATA
  ATATTTAGTTTGGATTTATGAAAGTACTTCACCACCCCGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_014243
• ORF Size: 3618 bp
• Insert Size: 4600
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info

Reference Data

• RefSeq: NM_014243.1, NP_055058.1
• RefSeq Size: 5821
• RefSeq ORF: 3618
• Locus ID: 9508
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]