Cezanne (OTUD7B) (BC020622) Human Untagged Clone

CAT#: SC122353

OTUD7B (untagged)-Homo sapiens, Similar to cellular zinc finger anti-NF-kappaB Cezanne, clone MGC:22237 IMAGE:4294961, complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: OTUD7B
• Synonyms: cellular zinc finger anti-NF-kappaB Cezanne; CEZANNE; OTTHUMP00000014192; OTU domain containing 7B; ZA20D1; zinc finger, A20 domain containing 1; zinc finger protein Cezanne
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC020622 edited
  GGCAAAAAGCCACTGGGGGAGGCCAGTCCCGATCAGTCCTTTCTGGCTCCAGCTCCAGAT
  CCCGTGCGGAGCAACAGCTGCGGCCTGAATTTTGATCTATGTTCTACCTACATCCAGCTG
  GCTGAAAGTACTTGAGGATCACATGACCCTGGACATGGATGCTGTTCTGTCAGATTTTGT
  CCGTTCCACAGGAGCAGAGCCAGGGCTAGCGCGAGATCTCCTAGAAGGAAAGAATTGGGA
  TGTGAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAAGTCCATGCTGGAAACCTACC
  CCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAGGACCCCTGAAAAAGGGTTTTCTGACAG
  AGAGCCTACTCGCCCTCCCCGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAGAAAA
  ACGCCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTGGCCCGGTCCCA
  TGTCTCCTCCAATGGTGGGGGTGGGGGGAGCAATGAGCACCCCCTGGAAATGCCCATCTG
  TGCCTTCCAGCTTCCAGATCTCACTGTATACAATGAAGACTTCCGCAGCTTCATAGAGAG
  AGACCTCATTGAGCAGTCCATGCTGGTTGCCTTGGAACAGGCAGGGCGTTTGAACTGGTG
  GGTGAGTGTGGATCCCACCTCTCAGAGGCTGCTTCCTTTGGCAACTACTGGAGATGGGAA
  CTGCCTCCTGCATGCAGCCTCCCTTGGAATGTGGGGTTTCCATGATCGGGACTTGATGCT
  GCGGAAAGCTTTGTATGCACTGATGGAGAAGGGAGTTGAGAAGGAAGCGTTGAAAAGGCG
  CTGGAGGTGGCAGCAGACACAGCAGAATGAAGAGTCAGGGCTGGTATACACAGAAGATGA
  ATGGCAGAAGGAGTGGAATGAACTGATCAAGCTTGCCTCAAGTGAACCCCGAATGCATCT
  AGGTACCAATGGAGCCAACTGTGGTGGGGTGGAGAGTTCTGAGGAGCCTGTATATGAGAG
  CCTTGAAGAGTTTCACGTCTTTGTCCTTGCTCATGTGCTTAGGAGGCCCATAGTCGTCGT
  GGCAGACACCATGCTGAGGGACTCCGGAGGGGAAGCATTTGCCCCTATTCCCTTTGGAGG
  AATCTATCTGCCTTTGGAGGTCCCAGCCAGCCAGTGTCACCGCTCCCCTCTGGTGCTCGC
  CTATGATCAGGCCCACTTTTCTGCACTCGTGTCCATGGAGCAGAAGGAGAATACCAAGGA
  ACAAGCTGTGATCCCACTTACAGATTCAGAGTATAAGCTGCTGCCCTTGCACTTTGCTGT
  GGACCCTGGAAAGGGCTGGGAGTGGGGCAAAGATGATAGTGACAATGTCCGATTGGCCAG
  TGTAATTCTGTCCCTAGAGGTCAGATTGCATCTGCTGCATAGCTAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC020622 unedited
  GGGGACTAGGATTTGTAATACGACTTACTATAGGCGGCCGCGACATTCGCCATTACGGCC
  GGGGGGCAAAAAGCCACTGGGGGAGGCCAGTCCCGATCAGTCCTTTCTGGCTCCAGCTCC
  AGATCCCGTGCGGAGCAACAGCTGCGGCCTGAATTTTGATCTATGTTCTACCTACATCCA
  GCTGGCTGAAAGTACTTGAGGATCACATGACCCTGGACATGGATGCTGTTCTGTCAGATT
  TTGTCCGTTCCACAGGAGCAGAGCCAGGGCTAGCGCGAGATCTCCTAGAAGGAAAGAATT
  GGGATGTGAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAAGTCCATGCTGGAAACC
  TACCCCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAGGACCCCTGAAAAAGGGTTTTCTG
  ACAGAGAGCCTACTCGCCCTCCCCGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAG
  AAAAACGCCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTGGCCCGGT
  CCCATGTCTCCTCCAATGGTGGGGGTGGGGGGAGCAATGAGCACCCCCTGGAAATGCNCA
  TCTGTGCCTTCCAGCTTCCAGATCTCACTGTATACAATGAAGACTTCCGCAGCTTCATAG
  AGAGAGACCTCATTGAGCAGTCCATGCTGGTTGCCTTGGAAACAGCAGGNCGTTTGAACT
  GGTGGGTGAGTGTGGATCCCACCTCTCAGAGGCTGCTTCCTTTGGCAACTACTGGAGATG
  GGAACTGCCTNCTGCATGCAGCCTCCCTTGGAAATGTGGGGTTTCCATGATCCGGACTTG
  ATGCTGCGGGAAGCTTTGTATGCACTGATGGAGAAGGAGTTGAGAAGAAGCGTTGAAAAG
  CGCTGGNAGTGGCA
  
• Restriction Sites: Please inquire
• ACCN: BC020622
• Insert Size: 1454
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC020622.1, AAH20622.1
• RefSeq Size: 1454
• Locus ID: 56957
• Gene Summary: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProtKB/Swiss-Prot Function]