CLACP (COL25A1) (BC036669) Human Untagged Clone

CAT#: SC122503

COL25A1 (untagged)-Human collagen, type XXV, alpha 1 (cDNA clone MGC:33431 IMAGE:5268875), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COL25A1
• Synonyms: CLAC; CLACP; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; OTTHUMP00000196081; OTTHUMP00000196082
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC036669 edited
  GAGGGGCCACTGTTGGGGCCCTCGAAAGAGGTGTCGGTCCTCTGGGAGTCGGAAGAGCTG
  TCTGGGATTATTTGAGGTGTAGAGGGTGGGAAGCGAAGCCGAGACGGCCGACCCCGCCAC
  GATGCTGCTGAAGAAGCACGCAGGGAAAGGAGGGGGCCGGGAGCCCAGATCCGAGGACCC
  GACCCCTGCCGAACAGCATTGTGCCCGGACCATGCCCCCGTGTGCCGTCCTGGCGGCCCT
  CCTGTCAGTGGTGGCCGTGGTGTCTTGCCTGTACCTGGGTGTGAAAACCAACGACCTCCA
  GGCGAGGATCGCCGCTCTCGAATCCGCCAAAGGGGCCCCTTCCATTCATCTGCTGCCTGA
  TACCCTGGATCACCTCAAGACTATGGTGCAAGAGAAAGTGGAGCGACTTCTGGCTCAGAA
  ATCCTATGAACATATGGCTAAAATAAGAATCGCAAGAGAAGCACCTTCAGAATGTAACTG
  CCCAGCAGGCCCTCCAGGGAAACGAGGTAAGAGAGGCCGAAGAGGAGAATCTGGTCCTCC
  TGGACAGCCTGGTCCTCAGGGCCCTCCTGGTCCAAAAGGCGATAAGGGAGAACAAGGTGA
  TCAGGGACCTAGGGGTCCTCTAGGGCCTCCGGGACAAAAGGGTTCTATTGGAGCACCTGG
  AATTCCAGGGATGAATGGGCAAAAGGGTGAGCCCGGGTTGCCTGGAGCAGTAGGACAGAA
  TGGAATACCAGGACCTAAGGGAGAACCTGGAGAACAAGGTGAAAAGGGAGACGCTGGAGA
  GAACGGCCCCAAGGGTGACACAGGCGAAAAGGGTGACCCTGGATCATCTGCTGCAGGAAT
  TAAGGGAGAACCTGGGGAATCTGGTCGTCCAGGGCAAAAGGGTGAACCAGGGCTTCCTGG
  GCTTCCTGGACTTCCGGGGATAAAGGGAGAACCAGGTTTCATTGGTCCTCAAGGAGAACC
  AGGCTTACCAGGTTTACCAGGAACAAAAGGTGAACGGGGGGAAGCAGGGCCTCCTGGAAG
  AGGTGAGCGAGGGGAACCTGGAGCCCCCGGACCAAAGGGGAAACAAGGTGAATCAGGAAC
  TAGAGGCCCAAAGGGGTCAAAGGGGGATCGTGGAGAAAAAGGGGACTCTGGAGCTCAGGG
  ACCAAGGGGTCCACCTGGTCAAAAAGGGGATCAAGGAGCCACTGAGATCATAGACTACAA
  CGGCAACCTCCACGAAGCCTTACAGAGGATTACCACCTTAACTGTCACGGGTCCCCCTGG
  ACCTCCTGGACCTCAAGGACTACAAGGGACAAAGGGAGAGCAGGGATCTCCAGGAATCCC
  AGGGATGGATGGAGAGCAGGGACTCAAAGGCTCAAAGGGAGACATGGGGGACCCAGGGAG
  CCAATGGAATGAAAGGAGAAAAAGGAGATTCTGGAATGCCGGGTCCACAGGGTCCTTCTA
  TCATAGGCCCACCAGGCCCACCAGGTCCCCATGGCCCACCTGGCCCCATGGGACCTCATG
  GACTTCCTGGACCAAAGGGAGCATCTGGCTTAGACGGAAAGCCAGGATCCCGGGGTACAG
  ATGGTCCTATGGGACCCCATGGCCCTGCAGGTCCCAAAGGAGAAAGAGGTGAAAAAGGAG
  CTATGGGAGAGCCTGGACCAAGAGGGCCCTATGGGCTGCCTGGGAAAGATGGAGAGCCTG
  GTCTTGATGGCTTCCCTGGTCCACGGGGTGAGAAGGGTGATCTAGGAGAAAAGGGCGAAA
  AGGGGGAAAAGGGAAAGAAAGGCAAAAAGGGGCCTAAAGGGGAGAAAGGAGAACAGGGTG
  CTCCTGGATTAGATGCACCCTGCCCGTTGGGGCCAGATGGCTTACCCATGCCTGGCTGTT
  GGCAAAAGTGATGAATCTAACCTTTCAAGCATGAAGTTGTGTATATAAGGGTCCATTTTT
  AATATTTATAGTTGAAAACTGAATTGCAGATTTTACAAGTCTGAGATATGTTTACATAGG
  GCTGCTTCTTCCTGTTGGCAGTAGTATACATGTCCATTTTTACTCCACTTACATCTGAAA
  TTGGGCAATTTGTGAAACCAGTGAGAATCCTGCAAAAAATATAGATCAGTATCTCCTTAT
  CTTATGTGAAGATACGTATTTATATGGACAAATCAGTGGTAGAGAATGATTGATTGTACT
  AGCTATTTTCCTTCTTTTGGCTTGCTAATTGCATGGACAAAAAGTGCCATGAAATAGTTT
  ACATGAAATGGTGACCAAATATGGACTCAAAGCTATGAAAATGTACTATACTGACTGATT
  TTAGAGCTGATTATCACATTCCCATTCACCTTTCATGTCGGCGTTGACTCATACCTACAC
  CACCCATTGAAACTAACTAAAAAAGCATGACTGTGTGCCAACCTGCTTGCTGTGCAACTT
  CAGATGCTAGCATGTTGATCAGGAGTCCTTTGATTACATCTGAACCTTTATTCCTTTTGT
  CATCTCAAGGGGGTTACACCATGGCTTATTGCCAAAAAGAGATAAGGTGGCGGAGAGCAC
  ACACACAATTTGTCTTGTATTTTGAGGGAGTTGCAGTCCTGACTGCAGATCTACAGCTTC
  CAGTATTGTGGGCTCATGTGGCCACTTTGGTTGAAATACGAAGGGGTTGAGCCTGTTGCT
  GCCACCAGTTTTCCTTGGGCTGCCCTTGGCAGTGAAGACATGGGAAGAGGACCGATTCAG
  CCTCCAGCACTGCCTCTCATGTGACCAAGTAGGAAAGAGGTTTACAAATGCAAACTTGCA
  GAACCACAGACTTTAAAAATATGTATAAATAAACTGAATTTCAGCAAGTGTTAATATAGG
  TGCTTTTAAAAATGACAGAGGCACAGCACTTCTTTTGGAATAGGAGATTCTTGGAATGGG
  AGATCCTGTCCCTGAGGGAAAAGGGATGTCCATCCCACCAAAACTTGGGTTGCTGAAGAA
  ATAACATGTTCTGAGAAGGGATCAGCCAAAATCGCCTCTCCCGATGATATAGGAGAGCTT
  ACTGGGACAATCTGTGCCAAAGTTGTTGTGAGAGCTTTCCTTCCTCCTACGATCCAACCA
  TGTCAAACATTTCCTACAAAGTTTGAGAAACAGACCAAATCTAAGATCTCAGAAAGCTGT
  GAAATATAGTTGCCATAAAGAAAATATTTTTCATCTACTTGCTCAAACTTTACCTAACCA
  TATTAGATGGAACATTTCTTTGCACAGTAAAGAGTTGGTAGCGTGTTTTGAAATGGCTTA
  TTCTAAGTGGAAGTGTTACATTGAAAGAAACATTATCAATGAGGAGTAGGCACCCTTTCA
  GCCCATTAGAGAATTCAATTTCTCTCCTGACTCAATGCCATCTTCTGGGAAGATTTCTAG
  TTTCATGCATAGGTGTCACCGCCAGAAGGGAAATTAACTCATCCTTGGCTTATAGTTAAG
  ATATAACCATAAGACAAGGAACCTAAAATCCTCATGATCTCATTTATGTTATGTAACCAA
  ATGACAGTCATACAAAATGGTATCTTCTTTTTTTTCTATTAAATTTTTAAGGTTGAAAGA
  TGTTTAAACTATTAGATCAGTCTAATTGGTAACATTTCTGGTAACATTCCACACCCCTAA
  GCCAGTTTAGCATTTTGAAAATAATGGAGGACATTTTCTAACAATTTCTTGTATGGCATG
  GTGTTAGGATAACGTATTGCTCAATGTCTGACACAATTTGTCTTAAATGGTTTGGAAAAA
  TGAACTGAAGTGGGTGGAACTACATTCTCTTCAGGAAAACAAACTACAGTGTCCAGTGGC
  TATATTTTTTTCCCTTCTATCTTTTTTTCTGCTCCTCTAGTAGAAAGAGGTGGATTGAAA
  TGGATCACTATTTAAAACTTGCACAGCTTCAGGAGACGATACCTCAACATCAAAAGAAAA
  ACACTTTATGTATAAAAAAATTTTTTGAAATACAGCCCTTCAAAGAATACTATTCTGTCC
  TGTGTGTATATTGAGTTTTTGCTCTATAACTGATTTGACAACATCAACTTATTTCATGAT
  TAAATGAGGTTGTAAACTTTCATTACATTTATTTCCTTGGGAAAAACAAAGGGATGGAAA
  TACTCCTCCTTGTTCAGTGGAATTGCTAGGTCTTAACCGTGATGGATAATCTTTAACTTT
  TGGTTACTACAATGTTTTCAAGCATCCATTTTGTCATATAGAGAATTCTTAAATAATTTC
  TAAGTGAATGAAAGAATTGTGTTTGTTGATATGTGTTGATAGATAATATACTTTCCTTAA
  AGATTTCTTTAATGTGTGTTATTGGATAGAGGGTTGAGAAAATATACATGAAAGACACAT
  TGGAAATAAGGCAAGGTCAGTTTCTATTTCTAATAAAACATTGAAGGATAGCAAATTGAT
  ATGTGTTTTAGATTTAAAATTGTTTTTCATTTATGTTGGTTGGTGCTAATGTATCTCTTT
  TCCTTTTTCTCTATGGACAATACAACTACTATGGATAATTTTATTTCCCTGTTTAATAGC
  ATTCCTAAATCATTAGTGTGTTATTTTATTTTTAAAGTTCATGAATTTGCTATAATTATG
  GTCCAATGACCAGGCTTTCTTAATGTAAAACAAAACAGTGTACCAATAGATGATGTGTGT
  TTACTCGGAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC036669 unedited
  NGGGACTGGGGTTTGTTATACCACTTTTATGGGCGGCCGCATAACTTCGTATAGCATACA
  TTATACGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGGAGG
  GGCCACTGTTGGGGCCCTCGAAAGAGGTGTCGGTCCTCTGGGAGTCGGAAGAGCTGTCTG
  GGATTATTTGAGGTGTAGAGGGTGGGAAGCGAAGCCGAGACGGCCGACCCCGCCACGATG
  CTGCTGAAGAAGCACGCAGGGAAAGGAGGGGGCCGGGAGCCCAGATCCGAGGACCCGACC
  CCTGCCGAACAGCATTGTGCCCGGACCATGCCCCCGTGTGCCGTCCTGGCGGCCCTCCTG
  TCAGTGGTGGCCGTGGTGTCTTGCCTGTACCTGGGTGTGAAAACCAACGACCTCCAGGCG
  AGGATCGCCGCTCTCGAATCCGCCAAAGGGGCCCCTTCCATTCATCTGCTGCCTGATACC
  CTGGATCACCTCAAGACTATGGTGCAAGAGAAAGTGGAGCGACTTCTGGCTCAGAAATCC
  TATGAACATATGGCTAAAATAAGAATCGCAAGAGAAGCACCTTCAGAATGTAACTGCCCA
  GCAGGCCCTCCAGGGAAACGAGGTAAGAGAGGCCGAAGAGGAGAATCTGGTCCTCCTGGA
  CAGCCTGGTCCTCAGGGCCCTCCTGGTCCAAAGGCGATAAGGGAGAACAAGGTGATCAGG
  GACCTAGGGGTCCTCTAGGGCCTCCGGGACAAAAGGGTTCTATTGGAGCACCTGGAATTC
  CAGGGATGAATGGGCAAAAGGTGAGCCCGGGTTGCCTGGAGCAGTAGGACAGAATGGGAT
  ACCAGGACCTAAGGGAGAACCTGNAGAAACAAGTGAAAAGGGAGACGCTGGAGAGAACNG
  CCCCAAGGTGACACAGGCGAAAAGGGTGACCCTGGATCATCTGCTGCAGAATTNAA
  
• Restriction Sites: Please inquire
• ACCN: BC036669
• ORF Size: 1488 bp
• Insert Size: 4649
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: BC036669.2, AAH36669.1
• RefSeq Size: 4644
• RefSeq ORF: 1488
• Locus ID: 84570
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]