RAG2 (NM_000536) Human Untagged Clone

CAT#: SC122564

RAG2 (untagged)-Human recombination activating gene 2 (RAG2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: RAG2
• Synonyms: RAG-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_000536 edited
  ACTCTCTTTACAGTCAGCCTTCTGCTTGCCACAGTCATAGTGGGCAGTCAGTGAATCTTC
  CCCAAGTGCTGACAATTAATACCTGGTTTAGCGGCAAAGATTCAGAGAGGCGTGAGCAGC
  CCCTCTGGCCTTCAGACAAAAATCTACGTACCATCAGAAACTATGTCTCTGCAGATGGTA
  ACAGTCAGTAATAACATAGCCTTAATTCAGCCAGGCTTCTCACTGATGAATTTTGATGGA
  CAAGTTTTCTTCTTTGGACAAAAAGGCTGGCCCAAAAGATCCTGCCCCACTGGAGTTTTC
  CATCTGGATGTAAAGCATAACCATGTCAAACTGAAGCCTACAATTTTCTCTAAGGATTCC
  TGCTACCTCCCTCCTCTTCGCTACCCAGCCACTTGCACATTCAAAGGCAGCTTGGAGTCT
  GAAAAGCATCAATACATCATCCATGGAGGGAAAACACCAAACAATGAGGTTTCAGATAAG
  ATTTATGTCATGTCTATTGTTTGCAAGAACAACAAAAAGGTTACTTTTCGCTGCACAGAG
  AAAGACTTGGTAGGAGATGTTCCTGAAGCCAGATATGGTCATTCCATTAATGTGGTGTAC
  AGCCGAGGGAAAAGTATGGGTGCTCTCTTTGGAGGACGCTCATACATGCCTTCTACCCAC
  AGAACCACAGAAAAATGGAATAGTGTAGCTGACTGCCTGCCCTGTGTTTTCCTGGTGGAT
  TTTGAATTTGGGTGTGCTACATCATACATTCTTCCAGAACTTCAGGATGGGCTATCTTTT
  CATGTCTCTATTGCCAAAAATGACACCATCTATATTTTAGGAGGACATTCACTTGCCAAT
  AATATCCGGCCTGCCAACCTGTACAGAATAAGGGTTGATCTTCCCCTGGGTAGCCCAGCT
  GTGAATTGCACAGTCTTGCCAGGAGGAATCTCTGTCTCCAGTGCAATCCTGACTCAAACT
  AACAATGATGAATTTGTTATTGTTGGTGGCTATCAGCTTGAAAATCAAAAAAGAATGATC
  TGCAACATCATCTCTTTAGAGGACAACAAGATAGAAATTCGTGAGATGGAGACCCCAGAT
  TGGACCCCAGACATTAAGCACAGCAAGATATGGTTTGGAAGCAACACGGGAAATGGAACT
  GTTTTTCTTGGCATACCAGGAGACAATAAACAAGTTGTTTCAGAAGGATTCTATTTCTAT
  ATGTTGAAATGTGCTGAAGATGATACTAATGAAGAGCAGACAACATTCACAAACAGTCAA
  ACATCAACAGAAGATCCAGGGGATTCCACTCCCTTTGAAGACTCTGAAGAATTTTGTTTC
  AGTGCAGAAGCAAATAGTTTTGATGGTGATGATGAATTTGACACCTATAATGAAGATGAT
  GAAGAAGATGAGTCTGAGACAGGCTACTGGATTACATGCTGCCCTACTTGTGATGTGGAT
  ATCAACACTTGGGTACCATTCTATTCAACTGAGCTCAACAAACCCGCCATGATCTACTGC
  TCTCATGGGGATGGGCACTGGGTCCATGCTCAGTGCATGGATCTGGCAGAACGCACACTC
  ATCCATCTGTCAGCAGGAAGCAACAAGTATTACTGCAATGAGCATGTGGAGATAGCAAGA
  GCTCTACACACTCCCCAAAGAGTCCTACCCTTAAAAAAGCCTCCAATGAAATCCCTCCGT
  AAAAAAGGTTCTGGAAAAATCTTGACTCCTGCCAAGAAATCCTTTCTTAGAAGGTTGTTT
  GATTAGTTTTGCAAAAGCCTTTCAGATTCAGGTGTATGGAATTTTTGAATCTATTTTTAA
  AATCATAACATTGATTTTAAAAATACATTTTTGTTTATTTAAAATGCCTATGTTTTCTTT
  TAGTTACATGAATTAAGGGCCAGAAAAAAGTGTTTATAATGCAATGATAAATAAAGTCAT
  TCTAGACCCTATACATTTTGAAAATATTTTACCCAAATACTCAATTTACTAATTTATTCT
  TCACTGAGGATTTCTGATCTGATTTTTTATTCAACAAACCTTAAACACCCAGAAGCAGTA
  ATAATCATCGAGGTATGTTTATATTTATTATATGAGTCTTGGTAACAAATAACCTATAAA
  GTGTTTATGACAAATTTAGCCAATAAAGAAATTAACACCCAAAAGAATTAAATTGATTAT
  TTTGTGCAACATAACAATTCGGCAGTTGGCCAAAACTTAAAAGCAAGATCTACTACATCC
  CACATTAGTGTTCTTTATATACCTTCAAGCAACCCTTTGGATTATGCCCATGAACAAGTT
  AGTTTCTCATAGCTTTACAGATGTAGATATAAATATAAATATATGTATACATATAGATAG
  ATAATGTTCTCCACTGACACAAAAGAAGAAATAAATAATCTACATCAAAAAAAAAAAAAA
  AAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000536 unedited
  GGTCAAAATTTGTATACGACTCATATGGGCGGCNCGCGAATCGGCCATTACGGCCGGGGA
  CTCTCTTTACAGTCAGCCTTCTGCTTGCCACAGTCATAGTGGGCAGTCAGTGAATCTTCC
  CCAAGTGCTGACAATTAATACCTGGTTTAGCGGCAAAGATTCAGAGAGGCGTGAGCAGCC
  CCTCTGGCCTTCAGACAAAAATCTACGTACCATCAGAAACTATGTCTCTGCAGATGGTAA
  CAGTCAGTAATAACATAGCCTTAATTCAGCCAGGCTTCTCACTGATGAATTTTGATGGAC
  AAGTTTTCTTCTTTGGACAAAAAGGCTGGCCCAAAAGATCCTGCCCCACTGGAGTTTTCC
  ATCTGGATGTAAAGCATAACCATGTCAAACTGAAGCCTACAATTTTCTCTAAGGATTCCT
  GCTACCTCCCTCCTCTTCGCTACCCAGCCACTTGCACATTCAAAGGCAGCTTGGAGTCTG
  AAAAGCATCAATACATCATCCATGGAGGGAAAACACCAAACAATGAGGTTTCAGATAAGA
  TTTATGTCATGTCTATTGTTTGCAAGAACAACAAAAAGGTTACTTTTCGCTGCACAGAGA
  AAGACTTGGTAGGAGATGTTCCTGAAGCCAGATATGGTCATTCCATTAATGTGGTGTACA
  GCCGAGGGAAAAGTATGGGTGCTCTCTTTGGAGGACGCTCATACATGCCTTCTACCCACA
  GAAACCACAGAAAATGGAATAGTGTAGCTGACTGCCTGCCCTGTGTTTTCCTGGTGGGAT
  TTGAATTTGGGTGTGCTACATCATACATTTCTTCAGAACTTCANGATGGGCTATCTTTTC
  ATGTCTCTATTGCCAANATGACACATCTATATTTTAGGAGGACATTCACTGCCAATAATA
  TCCGGCCTGCCAACCTGTACAGAATAAGGA
  
• Restriction Sites: Please inquire
• ACCN: NM_000536
• ORF Size: 1584 bp
• Insert Size: 2414
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_000536.1, NP_000527.1
• RefSeq Size: 2414
• RefSeq ORF: 1584
• Locus ID: 5897
• Protein Families: Druggable Genome
• Protein Pathways: Primary immunodeficiency
• Gene Summary: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 3 and 4 encode the same protein.