QDPR (BC000576) Human Untagged Clone

CAT#: SC123801

QDPR (untagged)-Human quinoid dihydropteridine reductase (cDNA clone MGC:1657 IMAGE:3162690), complete cds

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: QDPR
• Synonyms: DHPR; PKU2; SDR33C1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for BC000576 edited
  GGGAGCCGGGCTGGCAGGAGCAGGATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGG
  GTGCTGGTGTACGGCGGCAGGGGCGCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCC
  CGCAACTGGTGGGTTGCCAGCGTTGATGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATC
  ATTGTTAAAATGACAGACTCGTTCACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGA
  AAGCTCTTGGGTGAAGAGAAGGTGGATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGG
  GGCAATGCCAAATCCAAGTCTCTCTTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATA
  TGGACATCGACCATCTCCAGCCATCTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTG
  ACCTTGGCTGGCGCAAAGGCTGCCCTGGATGGGACTCCTGGTATGATCGGGTACGGCATG
  GCCAAGGGTGCTGTTCACCAGCTCTGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCG
  CCCGGGGCAGCCGCCATCGCTGTGCTCCCGGTTACCCTGGATACCCCGATGAACAGGAAA
  TCAATGCCTGAGGCTGACTTCAGCTCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTC
  CATGACTGGATCACAGGGAAAAACCGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACC
  ACAGAAGGAAGGACGGAACTCACCCCAGCATATTTTTAGGCCTCATCTCAGTGCCTATGA
  GGGGCCTGCCAGAAAAGTCACTAACCTGTCTCAGTGTGGCCTTGTCCAGCCTTGTGTTTT
  CTGTAACCCCTGTTTGTGGTACGAGATAATGAGTCCTATTTTTCTCTCACATAATATGCA
  TTTGCTCTCCTAGGACAGTGTAATACATTTATGTGAAGTAAAGACATGCGAGACTGGTGG
  CCTGCAAATAGCATCCGTCAATCTGTGTTAACTGCATAGGGAGGGCTCTGCATAGCACCT
  GCTATAGCGGTGTCATGTTGGATCGCTTTTGTGACTGTTCATCTGTCCTTGACAGTGGCT
  GTCATCTTGACTACTTTGTTGATTTGTTGGTATTGGGGACATTTTAAAGGCTGAGTTATT
  TTTGAATGTCATGTTTATGTCATAGACGTAGTTTTCGCATCCTTGAATTAAACTGCCTTA
  ACTCCTTTTGTGGTATAAGCAAAACTCCATGGACTCTGTCCTGGTATCCTTTTCCTGTGT
  GGTTGCCCTGTGTCCTCTGGCCTAGGGTTAAGTGTGCAAGATAACTACTCGTGAGTATTC
  AGAATGTTGTTCCTAATAAATGCACTTGTTGTCTGTCTTCTTTAAAAAAAAAAAAAAAAA
  AAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for BC000576 unedited
  NGTACAGTACAAAATTTGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGGG
  AGCCGGGCTGGCAGGAGCAGGATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTG
  CTGGTGTACGGCGGCAGGGGCGCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGC
  AACTGGTGGGTTGCCAGCGTTGATGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATCATT
  GTTAAAATGACAGACTCGTTCACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAG
  CTCTTGGGTGAAGAGAAGGTGGATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGC
  AATGCCAAATCCAAGTCTCTCTTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGG
  ACATCGACCATCTCCAGCCATCTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACC
  TTGGCTGGCGCAAAGGCTGCCCTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCC
  AAGGGTGCTGTTCACCAGCTCTGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCC
  GGGGCAGCCGCCATCGCTGTGCTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCA
  ATGCCTGAGGCTGACTTCAGCTCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCAT
  GACTGGATCACAGGGAAAAACCGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCCAC
  AGAGGAAGGACCGAACTCACCCCAGCATATTTTTAGGCCTCATCTCATTGCCTATGAAGG
  GCCTGNCCAAAAAGTCACTTACCTGTCTCAGTGTGGCCTTGTCCAGCCCTGGTGTTTCTG
  TAACC
  
• Restriction Sites: Please inquire
• ACCN: BC000576
• Insert Size: 1394 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC000576.2, AAH00576.1
• RefSeq Size: 1385 bp
• Locus ID: 5860
• Cytogenetics: 4p15.32
• Protein Families: Druggable Genome
• Protein Pathways: Folate biosynthesis, Metabolic pathways
• Gene Summary: 'This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]'