Dystrobrevin alpha (DTNA) (NM_032975) Human Untagged Clone

CAT#: SC124351

DTNA (untagged)-Human dystrobrevin, alpha (DTNA), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DTNA
• Synonyms: D18S892E; DRP3; DTN; DTN-A; LVNC1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_032975, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGATTGAAGATAGTGGGAAAAGAGGAAATACCATGGCAGAAAGAAGACAGCTGTTTGCAGAGATGAGGG
  CTCAAGATCTGGATCGCATCCGACTCTCCACCTACAGAACAGCATGCAAGCTTAGGTTTGTTCAGAAGAA
  ATGCAATTTGCACCTGGTGGACATATGGAATGTCATAGAAGCATTGCGGGAAAATGCTCTGAACAACCTG
  GACCCAAACACTGAACTCAACGTGTCCCGCTTAGAGGCTGTGCTCTCCACTATTTTTTACCAGCTCAACA
  AACGGATGCCAACCACTCACCAAATCCATGTGGAGCAGTCCATCAGCCTCCTCCTTAACTTCCTGCTTGC
  AGCGTTTGATCCGGAAGGCCATGGTAAAATTTCAGTATTTGCTGTCAAAATGGCTTTAGCCACATTGTGT
  GGAGGGAAGATCATGGACAAATTAAGATATATTTTCTCAATGATTTCTGACTCCAGTGGGGTGATGGTTT
  ATGGACGATATGACCAATTCCTTCGGGAAGTTCTCAAACTACCCACGGCAGTTTTTGAAGGTCCTTCATT
  TGGTTACACAGAACAGTCAGCCAGATCCTGTTTCTCCCAACAGAAAAAAGTCACGTTAAATGGTTTCTTG
  GACACGCTTATGTCAGATCCTCCCCCGCAGTGTCTGGTCTGGTTGCCTCTTCTGCATCGACTAGCAAATG
  TGGAAAATGTCTTCCATCCGGTTGAGTGTTCCTACTGCCACAGTGAGAGTATGATGGGATTTCGCTACCG
  ATGCCAACAGTGTCACAATTACCAGCTCTGTCAGGACTGCTTCTGGAGGGGACATGCCGGTGGTTCTCAT
  AGCAACCAGCACCAAATGAAAGAGTACACGTCATGGAAATCACCTGCTAAGAAGCTGACTAATGCATTAA
  GCAAGTCCCTGAGCTGTGCTTCCAGCCGTGAACCTTTGCACCCCATGTTCCCAGATCAGCCTGAGAAGCC
  ACTCAACTTGGCTCACATCGTTGATACTTGGCCTCCCAGACCTGTAACCAGCATGAACGACACCCTGTTC
  TCCCACTCTGTTCCCTCCTCAGGAAGTCCTTTTATTACCAGGAGCATGCTTGAGAGTTCAAACCGGCTTG
  ATGAAGAACACAGGCTAATTGCCAGGTATGCGGCAAGGCTGGCAGCAGAGTCCTCTTCGTCTCAGCCACC
  TCAGCAGAGAAGTGCTCCTGACATCTCTTTCACCATCGATGCGAATAAGCAGCAAAGGCAGCTGATTGCT
  GAGCTAGAAAACAAGAACAGAGAAATCTTACAGGAGATCCAGAGACTTCGGCTAGAGCATGAACAAGCTT
  CTCAGCCCACGCCAGAGAAGGCACAGCAAAACCCCACCCTGCTGGCAGAACTCCGGCTCCTCAGACAGCG
  CAAAGATGAGCTGGAACAGAGAATGTCTGCTCTCCAGGAGAGCCGGAGAGAGCTAATGGTCCAGTTGGAG
  GGTCTCATGAAGCTACTAAAGACTCAGGGGGCAGGCTCTCCCCGCTCCTCCCCCAGCCACACCATCAGCA
  GGCCAATTCCCATGCCCATCCGGTCAGCGTCAGCCTGCTCCACCCCGACGCACACGCCGCAGGACTCCCT
  CACAGGAGTAGGGGGAGATGTACAAGAGGCATTTGCACAAAGTTCAAGAAGAAACTTAAGGAATGACTTG
  CTAGTGGCTGCAGATTCCATCACTAACACTATGTCCTCTCTTGTGAAAGAGCTGAATTCTGAGGTTGGGA
  GTGAAACAGAGAGTAATGTGGATTCTGAATTTGCACGGACTCAGTTTGAGGATCTTGTTCCCTCACCAAC
  CTCTGAAAAGGCTTTTCTAGCGCAAATCCATGCCCGAAAACCTGGGTACATTCACAGTGGAGCTACCACA
  AGTACCATGCGTGGCGACATGGTTACGGAGGATGCAGATCCCTATGTGCAGCCTGAAGATGAAAACTATG
  AAAATGACTCTGTCCGGCAGCTGGAGAATGAGCTCCAGATGGAGGAATACCTGAAACAGAAGCTGCAAGA
  TGAAGCTTATCAGGTCAGCTTGCAAGGTTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_032975 unedited
  GGGGGTTCAAATTTTGTAACACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGATTT
  TAGAATGATTGAAGATGTGGGAAAAGAGAATACCATGGCAGAAAGAAGACAGCTGTTTGC
  AGAGATGAGGGCTCAAGATCTGGATCGCATCCGACTCTCCACCTACAGAACAGCATGCAA
  GCTTAGGTTTGTTCAGAAGAAATGCAATTTGCACCTGGTGGACATATGGAATGTCATAGA
  AGCATTGCGGGAAAATGCTCTGAACAACCTGGACCCAAACACTGAACTCAACGTGTCCCG
  CTTAGAGGCTGTGCTCTCCACTATTTTTTACCAGCTCAACAAACGGATGCCAACCACTCA
  CCAAATCCATGTGGAGCAGTCCATCAGCCTCCTCCTTAACTTCCTGCTTGCAGCGTTTGA
  TCCGGAAGGCCATGGTAAAATTTCAGTATTTGCTGTCAAAATGGCTTTAGCCACATTGTG
  TGGAGGGAAGATCATGGACAAATTAAGATATATTTTCTCAATGATTTCTGACTCCAGTGG
  GGTGATGGTTTATGGACGATATGACCAATTCCTTCGGGAAGTTCTCAAACTACCCACGGC
  AGTTTTTGAAGGTCCTTCATTTGGTTACACAGAACAGTCAGCCAGATCCTGTTTCTCCCA
  ACAGAAAAAAGTCACGTTAAATGGTTTCTTGGACACGCTTATGTCAGATCCTCCCCCGCA
  GTGTCTGGTCTGGTTGCCTCTTCTGCATCGACTAGCAAATGTGGAAAATGTCTTCCATTC
  GGNTGAGTGNTCCTACTGCCACAGTGAGAGTATGATGGGGATTTCGCTACCGATGCCAAC
  AGTGTCACAATTACCAGCTCTGTCAGGACTGCTTCTGGAGGAGACATGCNCGNTGGTTCT
  CATTAGCACCAGCNCCCAATGNAAGAGTACACGTCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_032975 unedited
  CTATGAACCCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGGTTCAAAAG
  TAAAAATGCCCTTTCTTCTAAGGACAGTGGAGTTCTCACTTGTGGCTCCTTGCGTGGAAT
  CGAACCAAGGGGAATGCAGCAACCAAAGGTTGCTGGATTTACAAGATCTATCTACGGTTA
  ACAGCCAAGAACTAATAAGGGTGGACAAAGATGATCAAAATAAAAGCAGACATCAGTGCT
  AAATTATGATGCAACAGTTTGGCTCATGCATATAAGAAAATACATAGTATATCACAACAA
  AGGCCACACACTCTTAATGCAATTCAGTTCACATTACTACTTACAAATGAACCTTCCCTG
  CCTTATAGTAGATCATTCAAGAACCCATTTTTCACAATCTCCAGCACAACTCCCTCTGAC
  CAACCAAACTTACCCCAACTTCCGTCCTGACCAACCACAACTGTTTCCTGAATCCCATGC
  AGTAGATTTCACCTTCCTCCCCTCCTCCATTAATATGGCGCTGTGGAGGAGGGTTGGCTG
  TGTTAGACCAGTGCTTATTAACAGGCTATCAGCTCTGATGGAGATGGATGTGCAATTCAT
  TGTGGAACAAGAAAGAAACAACCCCCGCAAGATGTAGTTGTATCTAATGGACAGGACAAG
  TGAAACTTGCTGGGTTTGCACTTAGAACAGGCCCCAAAAGTAAATCTGGAGAGCCAAGGA
  AAGAAACCCACCAAAAAACACAAAACCCCAAAATACACACGCCATTTTGTCTCGCTTACA
  GGACAGGGGTGCTCGAGTCTGGTCTCANTGCTGACGTGGAGTTGAGAAGAGTGTGATAAA
  AAGATATTGCATTCAACCCTGCAAGCTGACCTGATAAGCTTCATCTTGCAGCTTCTGTTT
  CAGGTATTCCTNCATCTGGAGCTCATTTCTCAGCTGCCGGACAGAGTCATTTCATAGTTT
  TCATCTTCAGGCTGCCATC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_032975
• Insert Size: 3090 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_032975.1, NP_116757.1
• RefSeq Size: 6537 bp
• RefSeq ORF: 6537 bp
• Locus ID: 1837
• Cytogenetics: 18q12.1
• Domains: ZnF_ZZ
• Protein Families: Druggable Genome
• Gene Summary: 'The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2), also known as alpha transcript, lacks two consecutive in-frame coding exons, compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.