MCCC2 (NM_022132) Human Untagged Clone

CAT#: SC125472

MCCC2 (untagged)-Human methylcrotonoyl-CoA carboxylase 2 (beta) (MCCC2), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MCCC2
• Synonyms: MCCB
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_022132 edited
  TCGGCACGAGCTGCAAGGACCTGAGCTCAGCTTCCGCCCCAGCCAGGGAAGCGGCAGGGG
  AAAGCACCGGCTCCAGGCCAGCGTGGGCCGCTCTCTCGCTCGGTGCCCGCCGCCATGTGG
  GCCGTCCTGAGGTTAGCCCTGCGGCCGTGTGCCCGCGCCTCTCCCGCCGGGCCGCGCGCC
  TATCACGGGGACTCGGTGGCCTCGCTGGGCACCCAGCCGGACTTGGGCTCTGCCCTCTAC
  CAGGAGAACTACAAGCAGATGAAAGCACTAGTAAATCAGCTCCATGAACGAGTGGAGCAT
  ATAAAACTAGGAGGTGGTGAGAAAGCCCGAGCACTTCACATATCAAGAGGAAAACTATTG
  CCCAGAGAAAGAATTGACAATCTCATAGACCCAGGGTCTCCATTTCTGGAATTATCCCAG
  TTTGCAGGTTACCAGTTATATGACAATGAGGAGGTGCCAGGAGGTGGCATTATTACAGGC
  ATTGGAAGAGTATCAGGAGTAGAATGCATGATTATTGCCAATGATGCCACCGTCAAAGGA
  GGTGCCTACTACCCAGTGACTGTGAAAAAACAATTACGGGCCCAAGAAATTGCCATGCAA
  AACAGGCTCCCCTGCATCTACTTAGTTGATTCGGGAGGAGCATACTTACCTCGACAAGCA
  GATGTGTTTCCAGATCGAGACCACTTTGGCCGTACATTCTATAATCAGGCAATTATGTCT
  TCTAAAAATATTGCACAGATCGCAGTGGTCATGGGCTCCTGCACCGCAGGAGGAGCCTAT
  GTGCCTGCCATGGCTGATGAAAACATCATTGTACGCAAGCAGGGTACCATTTTCTTGGCA
  GGACCCCCCTTGGTTAAAGCGGCAACTGGGGAAGAAGTATCTGCTGAGGATCTTGGAGGT
  GCTGATCTTCATTGCAGAAAGTCTGGAGTAAGTGACCACTGGGCTTTGGATGATCATCAT
  GCCCTTCACTTAACTAGGAAGGTTGTGAGGAATCTAAATTATCAGAAGAAATTGGATGTC
  ACCATTGAACCTTCTGAAGAGCCTTTATTTCCTGCTGATGAATTGTATGGAATAGTTGGT
  GCTAACCTTAAGAGGAGCTTTGATGTCCGAGAGGTCATTGCTAGAATCGTGGATGGAAGC
  AGATTCACTGAGTTCAAAGCCTTTTATGGAGACACATTAGTTACAGGATTTGCTCGAATA
  TTTGGGTACCCAGTAGGTATCGTTGGAAACAACGGAGTTCTCTTTTCTGAATCTGCAAAA
  AAGGGTACTCACTTTGTCCAGTTATGCTGCCAAAGAAATATTCCTCTGCTGTTCCTTCAA
  AACATTACTGGATTTATGGTTGGTAGAGAGTATGAAGCTGAAGGAATTGCCAAGGATGGT
  GCCAAGATGGTGGCCGCTGTGGCCTGTGCCCAAGTGCCTAAGATAACCCTCATCATTGGG
  GGCTCCTATGGAGCCGGAAACTATGGGATGTGTGGCAGAGCGTATAGCCCAAGATTTCTC
  TACATTTGGCCAAATGCTCGTATCTCAGTGATGGGAGGAGAGCAGGCAGCCAATGTGTTG
  GCCACGATAACAAAGGACCAAAGAGCCCGGGAAGGAAAGCAGTTCTCCAGTGCTGATGAA
  GCGGCTTTAAAAGAGCCCATCATTAAGAAGTTTGAAGAGGAAGGAAACCCTTACTATTCC
  AGCGCAAGGGTATGGGATGATGGGATCATTGATCCAGCAGACACCAGACTGGTCTTGGGT
  CTCAGTTTTAGTGCAGCCCTCAACGCACCAATAGAGAAGACTGACTTCGGTATCTTCAGG
  ATGTAACTGGAATAAAAGGATGTTTTCTG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022132 unedited
  NGGGTTCAGAATTGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGCTGCAAGG
  ACCTGAGCTCAGCTTCCGCCCCAGCCAGGGAAGCGGCAGGGGAAAGCACCGGCTCCAGGC
  CAGCGTGGGCCGCTCTCTCGCTCGGTGCCCGCCGCCATGTGGGCCGTCCTGAGGTTAGCC
  CTGCGGCCGTGTGCCCGCGCCTCTCCCGCCGGGCCGCGCGCCTATCACGGGGACTCGGTG
  GCCTCGCTGGGCACCCAGCCGGACTTGGGCTCTGCCCTCTACCAGGAGAACTACAAGCAG
  ATGAAAGCACTAGTAAATCAGCTCCATGAACGAGTGGAGCATATAAAACTAGGAGGTGGT
  GAGAAAGCCCGAGCACTTCACATATCAAGAGGAAAACTATTGCCCAGAGAAAGAATTGAC
  AATCTCATAGACCCAGGGTCTCCATTTCTGGAATTATCCCAGTTTGCAGGTTACCAGTTA
  TATGACAATGAGGAGGTGCCAGGAGGTGGCATTATTACAGGCATTGGAAGAGTATCAGGA
  GTAGAATGCATGATTATTGCCAATGATGCCACCGTCAAAGGAGGTGCCTACTACCCAGTG
  ACTGTGAAAAAACAATTACGGGCCCAAGAAATTGCCATGCAAAACAGGCTCCCCTGCATC
  TACTTAGTTGATTCGGGAGGAGCATACTTACCTCGACAGCAGATGTGTTTCCAGATCGAG
  ACCACTTTGGCCGTACATTCTATAATCAGGCAATTATGTCTTCTAAAATATTGCACAGAT
  CGCAGTGGTCATGGGCTCCTGCACCGCNNAGAGAGCCTATGTGCCTGCCATGGCTGATGA
  AAACATCATTGTACGCAAGCAGGGTACCATTTTCTTGGCAGGACCCCCCTTGGNNTAAAG
  CGGCACTGGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_022132
• ORF Size: 1692 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_022132.3, NP_071415.1
• RefSeq Size: 2329
• RefSeq ORF: 1692
• Locus ID: 64087
• Domains: Carboxyl_trans
• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Valine, leucine and isoleucine degradation
• Gene Summary: This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
  Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data.