Lamin B Receptor (LBR) (NM_194442) Human Untagged Clone

CAT#: SC127050

LBR (untagged)-Human lamin B receptor (LBR), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LBR
• Synonyms: C14SR; DHCR14B; LMN2R; PHA; PHASK; TDRD18
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127050 sequence for NM_194442 edited (data generated by NextGen Sequencing)
  ATGCCAAGTAGGAAATTTGCCGATGGTGAAGTGGTAAGAGGTCGATGGCCTGGGAGTTCA
  CTTTATTATGAAGTAGAAATTCTGAGCCACGACAGCACCTCCCAGCTTTACACTGTGAAG
  TATAAAGATGGAACAGAGCTTGAATTGAAAGAGAATGATATTAAGCCTTTAACTTCCTTT
  AGGCAAAGGAAAGGTGGCTCAACTTCCAGTTCCCCTTCCAGACGCCGAGGGAGTCGATCA
  AGGTCACGCTCCCGATCCCCTGGTCGACCACCTAAAAGTGCCCGCCGATCTGCTTCTGCT
  TCCCACCAGGCCGACATTAAGGAAGCAAGGAGGGAAGTGGAAGTTAAATTGACTCCGCTG
  ATTCTGAAGCCATTTGGAAATAGCATCAGCAGATATAATGGGGAGCCTGAGCATATTGAG
  AGAAATGACGCACCTCATAAAAATACACAGGAAAAATTCAGTTTGTCACAAGAAAGCAGT
  TACATAGCAACACAGTATAGCCTTCGTCCAAGAAGAGAAGAAGTCAAATTAAAAGAAATA
  GATTCTAAGGAAGAAAAATACGTTGCAAAAGAACTGGCAGTGAGAACCTTTGAAGTGACC
  CCCATCCGGGCAAAGGACTTGGAGTTTGGAGGAGTACCTGGTGTGTTTCTCATCATGTTT
  GGCCTGCCTGTGTTCCTCTTCCTGTTGCTGTTGATGTGTAAACAGAAAGATCCCAGTCTT
  CTGAATTTCCCTCCTCCTTTGCCAGCTTTGTATGAGTTATGGGAAACCAGAGTATTTGGG
  GTCTACCTCCTGTGGTTTTTGATTCAAGTCCTGTTCTACCTACTGCCAATTGGAAAGGTT
  GTAGAAGGAACGCCTCTTATTGATGGAAGAAGACTCAAGTATAGATTAAATGGATTCTAT
  GCTTTTATCCTGACATCTGCAGTCATCGGAACATCTCTCTTCCAGGGCGTAGAGTTTCAT
  TACGTGTACAGTCATTTTCTTCAGTTTGCACTTGCGGCCACTGTTTTTTGTGTGGTCTTG
  AGTGTGTATCTCTACATGCGCTCTTTGAAAGCGCCCCGGAATGACCTGTCGCCTGCCAGC
  TCTGGAAATGCTGTCTATGATTTCTTCATTGGCCGTGAATTAAACCCTCGAATTGGTACT
  TTTGATCTCAAATACTTTTGTGAATTGCGCCCCGGATTGATTGGATGGGTGGTTATTAAC
  TTGGTGATGCTTTTGGCTGAAATGAAAATACAGGACCGCGCTGTTCCATCCTTGGCCATG
  ATTTTAGTTAATAGTTTCCAGCTTCTCTATGTGGTGGATGCTCTCTGGAATGAGGAAGCG
  TTGTTGACGACCATGGACATCATCCACGATGGATTTGGATTCATGCTGGCTTTTGGAGAC
  TTGGTGTGGGTTCCCTTTATTTACAGCTTCCAAGCCTTTTATTTAGTCAGTCATCCAAAT
  GAAGTGTCTTGGCCAATGGCTTCTCTAATTATTGTTCTGAAACTTTGTGGTTATGTAATC
  TTCCGAGGTGCAAATTCTCAGAAAAATGCATTCCGGAAAAATCCCAGTGATCCAAAGCTT
  GCACATTTAAAAACCATTCATACTTCAACGGGAAAAAATCTTCTAGTTTCTGGATGGTGG
  GGCTTTGTTCGCCACCCCAATTACTTGGGTGATCTCATCATGGCCTTGGCGTGGTCCCTC
  CCATGTGGTTTTAACCACATTCTGCCTTATTTCTACATAATTTATTTCACCATGTTGCTT
  GTCCACCGAGAAGCTCGTGACGAGTACCACTGTAAGAAGAAATACGGCGTGGCTTGGGAA
  AAGTACTGTCAGCGTGTGCCCTACCGTATATTTCCATACATCTACTAA
  
  Clone variation with respect to NM_194442.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_194442 unedited
  TCACCGCCGGAACCTGGCGCAGGTTAATTATAGAAAATGCCAAGTAGGAAATTTGCCGAT
  GGTGAAGTGGTAAGAGGTCGATGGCCTGGGAGTTCACTTTATTATGAAGTAGAAATTCTG
  AGCCACGACAGCACCTCCCAGCTTTACACTGTAAAGTATAAAGATGGAACAGAGCTTGAA
  TTGAAAGAGAATGATATTAAGCCTTTAACTTCCTTTAGGCAAAGGAAAGGTGGCTCAACT
  TCCAGTTCCCCTTCCAGACGCCGAGGGAGTCGATCAAGGTCACGCTCCCGATCCCCCGGT
  CGACCACCTAAAAGTGCCCGCCGATCTGCTTCTGCTTCCCACCAGGCCGACATTAAGGAA
  GCAAGGAGGGAAGTGGAAGTTAAATTGACTTCGCTGATTCTGAAGCCATTTGGAAATAGC
  ATCAGCAGATTTAATGGGGAAGCCTGAGCATATTGAGAGAAATGACGCACCTCATAAAAA
  TACACAGGAAAAATTCAATTTGTCACAAGAAAGCAGTTACATAGCAACACAGTATAGCCT
  TCGTCCAAGAAGAGAAGAAGTCAAATTAAAAGAAATAGATTCCTAAGGAAGAAAAATACC
  TTTGCAAAAGGACTTGCCCGTGAAGACCTTTNTAAAGTGACCCTCATCNCGGGCCAAGGA
  CTTGGGAGTTTGGGAGGAGTACCCTTGGCGGNGTTTCTCACTCATGTTTGGCCCCGCCCG
  GGNTTCCTTCTCTCCTGGTGGCCGNTGGAAGTGGTGAAAACAGAAGGAATACCAAGCCTT
  CTGGAATTTTCCCCTCCTCCTCTTNACACACTCTTGTTTGAGATTATGAGAACACCGCNA
  GTATTTGGGGTCTTC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_194442 unedited
  GGGTCTTCTCTGGNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTTTG
  ATCAAAATGTTGCTACATTTTATTTTCAACTTAAAACTTCATTATAAAATTTGCCAAATA
  AACATGTCAAAAACAAACTTAAAAACAAAGTGTAGCTGATATCCAGAAATTGCAGCACTG
  TATTGATAAAGGGCTCTTTTCATTACCAGGGAAAGAATTTAATGTCCTTCCTTCCTCCCC
  AAAAGCTTCCTTGGTGCAATCCAGTACAGAAAACGCCACCACTTTCTGATGCCAGGAGAA
  AAGCAAAATAAAAAAACTGCTTGCACACATTAGCACTGATAAAACAATGACAATTTCACT
  AAAAGAATGTTTAAAGACTACCGGATGCTGGAGCAAACCAACTTCATGACTGCATTAACA
  TAAGCTAAGTTACATACACTTCAAATGCAGTATAGAATTAACACTGCATATCTAAATGGC
  TCATATATAAAATGTGTAATTAAAACCCAAACATACACACTATGTTTATTACATTCCCCT
  ACATTGAAAGTACTGAGAACAATTTAACTCTGAACACAAAAGTTTAGTGAATTTGCTACT
  GTTCCATTACAGGACAATTAAAAATGAGACTATATCAACTTCACTAGAATTTAATTGCTA
  AAGCTACCTTATGCACATCTATTAAACTAAAAGAAACGACTTTAACCCCTTCAGTTGTTT
  TTAAGACAGCACTCCTTTACAGGGAGTCAGGTTTGGTAAATATAAAGGATACATAAAAAA
  TACAGTATAAACTGCATAAGCTTAACAGTAGCAAAACACTGATGAAACTTTAAAAGTCAA
  AAAATATAAAAATATAGCCTGAATGGGCAATNTCAAACACGATCTGTGTANAATGTTTAA
  TATTGATGTACTCCAAATATATAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_194442
• Insert Size: 3890 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_194442.1, NP_919424.1
• RefSeq Size: 3789 bp
• RefSeq ORF: 1848 bp
• Locus ID: 3930
• Cytogenetics: 1q42.12
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: 'The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.