Artemis (DCLRE1C) (NM_022487) Human Untagged Clone

CAT#: SC127058

DCLRE1C (untagged)-Human DNA cross-link repair 1C (DCLRE1C), transcript variant b


  "NM_022487" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol DCLRE1C
Synonyms A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC127058 sequence for NM_022487 edited (data generated by NextGen Sequencing)
ATGAAGCATCAGGAGAGGTTTTTATTTCAGGGCAATAATGGAACTGTCCTGTACACAGGA
GACTTCAGATTGGCGCAAGGAGAAGCTGCTAGAATGGAGCTTCTGCACTCCGGGGGCAGA
GTCAAAGACATCCAAAGTGTATATTTGGATACTACGTTCTGTGATCCAAGATTTTACCAA
ATTCCAAGTCGGGAGGAGTGTTTAAGTGGAGTCTTAGAGCTGGTCCGAAGCTGGATCACT
CGGAGCCCGTACCATGTTGTTTGGCTGAACTGCAAAGCGGCTTATGGCTATGAATATCTG
TTCACCAACCTTAGTGAAGAATTAGGAGTCCAGGTTCATGTGAATAAGCTAGACATGTTT
AGGAACATGCCTGAGATCCTTCATCATCTCACAACAGACCGCAACACTCAGATCCATGCA
TGCCGGCATCCCAAGGCAGAGGAATATTTTCAGTGGAGCAAATTACCCTGTGGAATTACT
TCCAGAAATAGAATTCCACTCCACATAATCAGCATTAAGCCATCCACCATGTGGTTTGGA
GAAAGGAGCAGAAAAACAAATGTAATTGTGAGGACTGGAGAGAGTTCATACAGAGCTTGT
TTTTCTTTTCACTCCTCCTACAGTGAGATTAAAGATTTCTTGAGCTACCTCTGTCCTGTG
AACGCATATCCAAATGTCATTCCAGTTGGCACAACTATGGATAAAGTTGTCGAAATCTTA
AAGCCTTTATGCCGGTCTTCCCAAAGTACGGAGCCAAAGTATAAACCACTGGGAAAACTG
AAGAGAGCTAGAACAGTTCACCGAGACTCAGAGGAGGAAGATGACTATCTCTTTGATGAT
CCTCTGCCAATACCTTTAAGGCACAAAGTTCCATACCCGGAAACTTTTCACCCTGAGGTA
TTTTCAATGACTGCAGTATCAGAAAAGCAGCCTGAAAAACTGAGACAAACCCCAGGATGC
TGCAGAGCAGAGTGTATGCAGAGCTCTCGTTTCACAAACTTTGTAGATTGTGAAGAATCC
AACAGTGAAAGTGAAGAAGAAGTAGGAATCCCAGCTTCACTGCAAGGAGATCTGGGCTCT
GTACTTCACCTGCAAAAGGCTGATGGGGATGTACCCCAGTGGGAAGTATTCTTTAAAAGA
AATGATGAAATCACAGATGAGAGTTTGGAAAACTTCCCTTCCTCCACAGTGGCAGGGGGA
TCTCAGTCACCAAAGCTTTTCAGTGACTCTGATGGAGAATCAACTCACATCTCCTCCCAG
AATTCTTCCCAGTCAACACACATAACAGAACAAGGAAGTCAAGGCTGGGACAGCCAATCT
GATACTGTTTTGTTATCTTCCCAAGAGAGAAACAGTGGGGATATTACTTCCTTGGACAAA
GCTGACTACAGACCAACAATCAAAGAGAATATTCCTGCCTCTCTCATGGAACAAAATGTA
ATTTGCCCAAAGGATACTTACTCTGATTTGAAAAGCAGAGATAAAGATGTGACAATAGTT
CCTAGTACTGGAGAACCAACTACTCTAAGCAGTGAGACACATATACCCGAGGAAAAAAGT
TTGCTAAATCTTAGCACAAATGCAGATTCCCAGAGCTCTTCTGATTTTGAAGTTCCCTCA
ACTCCAGAAGCTGAGTTACCTAAACGAGAGCATTTACAATATTTATATGAGAAGCTGGCA
ACTGGTGAGAGTATAGCAGTCAAAAAAAGAAAATGCTCACTCTTAGATACCTAA

Clone variation with respect to NM_022487.2
261 g=>t
>OriGene 5' read for NM_022487 unedited
TTGTAATCCGACTTACTATAGGGCGGCCGCGAATTCGGCACGAGGGCGGTTTTGGGGTCC
CGGACTCTGGGATCGGCGGCGCTATGAGTTCTTTCGAGGGGCAGATGGCCGAGTATCCAA
CTATCTCCATAGACCGCTTCGATAGGGAGAACCTGAGGGCCCGCGCCTACTTCCTGTCCC
ACTGCCACAAAGATCACATGAAAGGATTAAGAGCCCCTACCTTGAAAAGAAGGTTGGAGT
GCAGATGAGGAAACTGAGGAACCAGAGAGGTTAAATTAGTTGCCCAGTGTCACACAGCCA
GTAAGTGGCAGGACCAGGATTCCAGCCAGCTTGAAGGTTTATCTATACTGTTCACCTGTG
ACTAAGGAGTTGTTGTTAACGAGCCCGAAATACAGATCTTGGAAGAAACGAATTATATCT
ATTGAAATCGAGACTCCTACCCAGATATCTTTAGTGGATGAAGCATCAGGAGAGAAGGAA
GAGATTGTTGTGACTCTCTTACCAGCTGGTCACTGTCCGGGATCAGTTAAGTTTTTATTT
CAGGGCAATAATGGAACTGTCCTGTACACAGGAGACTTCAGATTGGCGCAAGGAGAAACT
GCTAGAATGGAGCTTCTGCACTCCGGGGGCAGAGTCAAAGACATCCAAAGTGTATACTTG
GATACTACGTTCTGTGATCCCCGAATTACCAAATTCCAAGTCCGGAGGCGTGGTTAAGTG
GGAGTCTTACAGCTGGTCCGAAGCTGGATCACTCGGAGCCCGTACCATGTTGNACGGGCT
GAACTGCAAACCGCCTTATTGCTTATGAATTCTTGTTCCCCACCCTTATGAACTATTAGG
ATCCAGGGTCTTGTGAATAAACTACAATGTTCAGGAACTTGCTGAATATCCTTATTATTT
TAAACAGA
>OriGene 3' read for NM_022487 unedited
TTACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGTAAGTAGAGACACA
TTTCACTGTGTTGGCCAGGCTGGTGTCGAACTCCTGGGCTCAAGCCATTGCCCACCTCAA
AGTGCTGGGATTACAAGTGTGAGCCACCACACCCAACCAGGTTATTTGAACATTTTTAAG
TACTGTATTTTCTCTATTGTAATATTGACTGTCATCTCTGTGCAGGTTTTTTAGTGGTTG
CTCTAGGTTGAAACGCTTTGAATTCTTAGGTATCTAAGAGTGAGCATTTTCTTTTTTTGA
CTGCTATACTCTCACCAGTTGCCAGCTTCTCATATAAATATTGTAAATGCTCTCGTTTAG
GTAACTCAGCTTCTGGAGTTGAGGGAACTTCAAAATCAGAAGAGCTCTGGGAATCTGCAT
TTGTGCTAAGATTTAGCAAACTTTTTTCCTCGGGTATATGTGTCTCACTGCTTAGAGTAG
TTGGTTCTCCAGTACTAGGAACTATTGTCACATCTTTATCTCTGCTTTTCAAATCAGAGT
AAGTATCCTTTGGGCAAATTACATTTTGTTCCATGAGAGAGGCAGGAATATTCTCTTTGA
TTGTTGGTCTGTAGTCAGCTTTGTCCAAGGAAGTAATATCCCCACTGTTTCTCTCTTGGG
AAGATAACANAACAGTATCAGATTGGCTGTCCCAGCCTTGACTTCCTTGTTCTGTTATGT
GTGTTGACTGGGAAGAATTCTGGGAGGAGATGTGAGTTGATTCTCCATCAGAGTCACCTG
AAAGCCTTGGTGACTGAGATCCCCCTGCCACTGTGGAGGAAGGNAAAGTTTTCAACTCTC
ATCTGGGATTTATCATTCCTTTTAAGAAACTNCCACTGGGGTACATCCCATCAGCCTTTG
CAGTGGAGTACAAAGCCAGATCN
Restriction Sites NotI-NotI     
ACCN NM_022487
ORF Size 1734 bp
Insert Size 2440
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Reference Data
RefSeq NM_022487.1, NP_071932.1
RefSeq Size 2636
RefSeq ORF 1734
Locus ID 64421
Protein Families Druggable Genome
Protein Pathways Cell cycle, Non-homologous end-joining, Primary immunodeficiency
Gene Summary This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcript Variant: This variant (b, also called V3) lacks an exon in the 5' coding region and initiates translation at an alternate downstream start codon, compared to variant a. It encodes isoform b, which has a shorter and distinct N-terminus compared to variant a. Variants b, e, and g encode the same isoform (b). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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