LRRC8A (NM_019594) Human Untagged Clone

CAT#: SC127734

LRRC8A (untagged)-Human leucine rich repeat containing 8 family, member A (LRRC8A), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LRRC8A
• Synonyms: AGM5; LRRC8; SWELL1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127734 sequence for NM_019594 edited (data generated by NextGen Sequencing)
  ATGATTCCGGTGACAGAGCTCCGCTACTTTGCGGACACGCAGCCAGCATACCGGATCCTG
  AAGCCGTGGTGGGATGTGTTCACAGACTACATCTCTATCGTCATGCTGATGATTGCCGTC
  TTCGGGGGGACGCTGCAGGTCACCCAAGACAAGATGATCTGCCTGCCTTGTAAGTGGGTC
  ACCAAGGACTCCTGCAATGATTCGTTCCGGGGCTGGGCAGCCCCTGGCCCGGAGCCCACC
  TACCCCAACTCCACCATTCTGCCGACCCCTGACACGGGCCCCACAGGCATCAAGTATGAC
  CTGGACCGGCACCAGTACAACTACGTGGACGCTGTGTGCTATGAGAACCGACTGCACTGG
  TTTGCCAAGTACTTCCCCTACCTGGTGCTTCTGCACACGCTCATCTTCCTGGCCTGCAGC
  AACTTCTGGTTCAAATTCCCGCGCACCAGCTCGAAGCTGGAGCACTTTGTGTCTATCCTG
  CTGAAGTGCTTCGACTCGCCCTGGACCACGAGGGCCCTGTCGGAGACAGTGGTGGAGGAG
  AGCGACCCCAAGCCGGCCTTCAGCAAGATGAATGGGTCCATGGACAAAAAGTCATCGACC
  GTCAGTGAGGACGTGGAGGCCACCGTGCCCATGCTGCAGCGGACCAAGTCACGGATCGAG
  CAGGGTATCGTGGACCGCTCAGAGACGGGCGTGCTGGACAAGAAGGAGGGGGAGCAAGCC
  AAGGCGCTGTTTGAGAAGGTGAAGAAGTTCCGGACCCATGTGGAGGAGGGGGACATTGTG
  TACCGCCTCTACATGCGGCAGACCATCATCAAGGTGATCAAGTTCATCCTCATCATCTGC
  TACACCGTCTACTACGTGCACAACATCAAGTTCGACGTGGACTGCACCGTGGACATTGAG
  AGCCTGACGGGCTACCGCACCTACCGCTGTGCCCACCCCCTGGCCACACTCTTCAAGATC
  CTGGCGTCCTTCTACATCAGCCTAGTCATCTTCTACGGCCTCATCTGCATGTACACACTG
  TGGTGGATGCTACGGCGCTCCCTCAAGAAGTACTCGTTTGAGTCGATCCGTGAGGAGAGC
  AGCTACAGCGACATCCCCGACGTCAAGAACGACTTCGCCTTCATGCTGCACCTCATTGAC
  CAATACGACCCGCTCTACTCCAAGCGCTTCGCCGTCTTCCTGTCGGAGGTGAGTGAGAAC
  AAGCTGCGGCAGCTGAACCTCAACAACGAGTGGACGCTGGACAAGCTCCGGCAGCGGCTC
  ACCAAGAACGCGCAGGACAAGCTGGAGCTGCACCTGTTCATGCTCAGTGGCATCCCTGAC
  ACTGTGTTTGACCTGGTGGAGCTGGAGGTCCTCAAGCTGGAGCTGATCCCCGACGTGACC
  ATCCCGCCCAGCATTGCCCAGCTCACGGGCCTCAAGGAGCTGTGGCTCTACCACACAGCG
  GCCAAGATTGAAGCGCCCGCGCTGGCCTTCCTGCGCGAGAACCTGCGGGCGCTGCACATC
  AAGTTCACTGACATCAAGGAGATCCCGCTGTGGATCTATAGCCTGAAGACACTGGAGGAG
  CTGCACCTGACGGGCAACCTGAGCGCGGAGAACAACCGCTACATCGTCATCGACGGGCTG
  CGGGAGCTCAAACGCCTCAAGGTGCTGCGGCTCAAGAGCAACCTAAGCAAGCTGCCACAG
  GTGGTCACAGATGTGGGCGTGCACCTGCAGAAGCTGTCCATCAACAATGAGGGCACCAAG
  CTCATCGTCCTCAACAGCCTCAAGAAGATGGCGAACCTGACTGAGCTGGAGCTGATCCGC
  TGTGACCTGGAGCGCATCCCCCACTCCATCTTCAGCCTCCACAACCTGCAGGAGATTGAC
  CTCAAGGACAACAACCTCAAGACCATCGAGGAGATCATCAGCTTCCAGCACCTGCACCGC
  CTCACCTGCCTTAAGCTGTGGTACAACCACATCGCCTACATCCCCATCCAGATCGGCAAC
  CTCACCAACCTGGAGCGCCTCTACCTGAACCGCAACAAGATCGAGAAGATCCCCACCCAG
  CTCTTCTACTGCCGCAAGCTGCGCTACCTGGACCTCAGCCACAACAACCTGACCTTCCTC
  CCTGCCGACATCGGCCTCCTGCAGAACCTCCAGAACCTAGCCATCACGGCCAACCGGATC
  GAGACGCTCCCTCCGGAGCTCTTCCAGTGCCGGAAGCTGCGGGCCCTGCACCTGGGCAAC
  AACGTGCTGCAGTCACTGCCCTCCAGGGTGGGCGAGCTGACCAACCTGACGCAGATCGAG
  CTGCGGGGCAACCGGCTGGAGTGCCTGCCTGTGGAGCTGGGCGAGTGCCCACTGCTCAAG
  CGCAGCGGCTTGGTGGTGGAGGAGGACCTGTTCAACACACTGCCACCCGAGGTGAAGGAG
  CGGCTGTGGAGGGCTGACAAGGAGCAGGCCTGA
  
  Clone variation with respect to NM_019594.3
  1014 t=>c;1509 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_019594 unedited
  ACTCACTATAGGGGCGGCCGCGAATCGGTACGAGGCTGCGGCCGGCGGCGGGACGGAGCG
  GCCGGGGCCTGGGGCTGCCTGCCGGGCGGCCGGGCGCGGCGAGCCCAGGGAGGCAGCGTC
  CATGGAGCAAAAGGAATGCCAGGATCCTGCACAGGCAGACGCGGGCCAGCCTCAGCACCG
  ACAGCCGACGCGCAGATAGCAGAGCCATCCTTGGGGTTGAACCATGATTCCGGTGACAGA
  GCTCCGCTACTTTGCGGACACGCAGCCAGCATACCGGATCCTGAAGCCGTGGTGGGATGT
  GTTCACAGACTACATCTCTATCGTCATGCTGATGATTGCCGTCTTCGGGGGGACGCTGCA
  GGTCACCCAAGACAAGATGATCTGCCTGCCTTGTAAGTGGGTCACCAAGGACTCCTGCAA
  TGATTCGTTCCGGGGCTGGGCAGCCCCTGGCCCGGAGCCCACCTACCCCAACTCCACCAT
  TCTGCCGACCCCTGACACGGGCCCCACAGGCATCAAGTATGACCTGGACCGGCACCAGTA
  CAACTACGTGGACGCTGTGTGCTATGAGAACCGACTGCACTGGTTTGCCAAGTACTTCCC
  CTACCTGGTGCTTCTGCACACGCTCATCTTCCTGGCCTGCAGCAACTTCTGGTTCAAATT
  CCCGCGCACCAGCTCGAAGCTGGAGCACTTTGTGTCTATCCTGCTGAAGTGCTTCGACTC
  GCCCTGGGACCACGAGGCCCTGTCGGAGACAGTGGTGGNAGAGAGCGACCCCAAGCCGGC
  CTTCAGCAGATGAATGGGTCCATGGGACAAAGTCATCGACCGGTCAGTGAGACGTGGAGG
  CACCGTNGCCATGCTGCC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_019594 unedited
  TCTATGGACGCGGCCGCTTTCTANAGTCGAGTTTTTTTTTTTTTTTTTTAATACCCAAAC
  CATCCATTTTCAAAGCTTTTTTTTTAAAAAAATGTTTTTTGATTAAAAAAAAAAAAACAA
  AAAACTAAAACTGCCACAAATACTGAAGAGGCAAGCTCCAGGCCTGGCCTTTCCAGCTGG
  AGGCCTGCTCTCCCGTGGACCGCACCGCAGAGCCCAGCCCGGCACTGCTGGGTGACCGTC
  CCATGGCTGGTTCGCCCCGGACCACTCTGCTGAAGTCCAGGTGGGTGTTAAATGCCCGGC
  GGCATCGCTAAATAAGGACAAGGGGAAAAGGCAGCCCACCTTTCCCTGAACACCTTCCAT
  CTGGGCTGAACTTTCTTGGGAATGTATAAGTTATCTGGATGAAGGAGGCGGGAGATGGAG
  AAAAATAAATACCAAGAACTAAAGTGAGGGTCCCAGGACCTCTGGTGGCAGCTCAGCCCC
  TGGGGCAGAGCTGGCCTCCAGGGAGGAGACCCTGATTATCCAAATACTGCGCTCTTGAGA
  CTTGCTCTCCTCCACAAGCACTTGCCCTGGGGGACGTGAGTCTCAGAGGGAGAAAAGGGG
  CCAGCCCCACAGATACTGTCCTCTCGCTCTGGCCTGACTCACAAGCGGCCCCAGGCTCCT
  GCCCAGCCACGAGCTGTCCTGCCTGTCCGGGAGTTCTGGGAGAACCTAGGCCTGCCCCTC
  CGGCCCTGAGGACCTGGCAGCGGTCCTGCTGCTTGCTGTGCTGGGCCCGCCTCGCTCAAC
  CCTGCTCCTTTGTAGCCCCTCCAAGCCGGTCTCTCACCTNGGGTGGAAGGGTGTGAACAG
  TCCCTCTACACCACAAACCGNTGNGCTTGACCAGGGGNACTCCCCAGCTTCAAGGCAGAA
  CTCCACCCGNTGCCCCCACTTAACTGGTCAGGTGCACACC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_019594
• ORF Size: 2433 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_019594.2, NP_062540.2
• RefSeq Size: 4296
• RefSeq ORF: 2433
• Locus ID: 56262
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.