Protein C (PROC) (NM_000312) Human Untagged Clone

CAT#: SC127914

PROC (untagged)-Human protein C (inactivator of coagulation factors Va and VIIIa) (PROC)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PROC
• Synonyms: APC; PC; PROC1; THPH3; THPH4
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127914 sequence for NM_000312 edited (data generated by NextGen Sequencing)
  ATGTGGCAGCTCACAAGCCTCCTGCTGTTCGTGGCCACCTGGGGAATTTCCGGCACACCA
  GCTCCTCTTGACTCAGTGTTCTCCAGCAGCGAGCGTGCCCACCAGGTGCTGCGGATCCGC
  AAACGTGCCAACTCCTTCCTGGAGGAGCTCCGTCACAGCAGCCTGGAGCGGGAGTGCATA
  GAGGAGATCTGTGACTTCGAGGAGGCCAAGGAAATTTTCCAAAATGTGGATGACACACTG
  GCCTTCTGGTCCAAGCACGTCGACGGTGACCAGTGCTTGGTCTTGCCCTTGGAGCACCCG
  TGCGCCAGCCTGTGCTGCGGGCACGGCACGTGCATCGACGGCATCGGCAGCTTCAGCTGC
  GACTGCCGCAGCGGCTGGGAGGGCCGCTTCTGCCAGCGCGAGGTGAGCTTCCTCAATTGC
  TCTCTGGACAACGGCGGCTGCACGCATTACTGCCTAGAGGAGGTGGGCTGGCGGCGCTGT
  AGCTGTGCGCCTGGCTACAAGCTGGGGGACGACCTCCTGCAGTGTCACCCCGCAGTGAAG
  TTCCCTTGTGGGAGGCCCTGGAAGCGGATGGAGAAGAAGCGCAGTCACCTGAAACGAGAC
  ACAGAAGACCAAGAAGACCAAGTAGATCCGCGGCTCATTGATGGGAAGATGACCAGGCGG
  GGAGACAGCCCCTGGCAGGTGGTCCTGCTGGACTCAAAGAAGAAGCTGGCCTGCGGGGCA
  GTGCTCATCCACCCCTCCTGGGTGCTGACAGCGGCCCACTGCATGGATGAGTCCAAGAAG
  CTCCTTGTCAGGCTTGGAGAGTATGACCTGCGGCGCTGGGAGAAGTGGGAGCTGGACCTG
  GACATCAAGGAGGTCTTCGTCCACCCCAACTACAGCAAGAGCACCACCGACAATGACATC
  GCACTGCTGCACCTGGCCCAGCCCGCCACCCTCTCGCAGACCATAGTGCCCATCTGCCTC
  CCGGACAGCGGCCTTGCAGAGCGCGAGCTCAATCAGGCCGGCCAGGAGACCCTCGTGACG
  GGCTGGGGCTACCACAGCAGCCGAGAGAAGGAGGCCAAGAGAAACCGCACCTTCGTCCTC
  AACTTCATCAAGATTCCCGTGGTCCCGCACAATGAGTGCAGCGAGGTCATGAGCAACATG
  GTGTCTGAGAACATGCTGTGTGCGGGCATCCTCGGGGACCGGCAGGATGCCTGCGAGGGC
  GACAGTGGGGGGCCCATGGTCGCCTCCTTCCACGGCACCTGGTTCCTGGTGGGCCTGGTG
  AGCTGGGGTGAGGGCTGTGGGCTCCTTCACAACTACGGCGTTTACACCAAAGTCAGCCGC
  TACCTCGACTGGATCCATGGGCACATCAGAGACAAGGAAGCCCCCCAGAAGAGCTGGGCA
  CCTTAG
  
  Clone variation with respect to NM_000312.3
  423 g=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000312 unedited
  TTACCTGATTNGTTANACCNAACTCGAGTGGGGCGTTCGCGACTTCCCGGTATCGGCGAA
  CTTGCTTTATCTCCACGACCCGCCCCTACAGGTGCCAGTGCCTCCAGAATGTGGCAGCTC
  ACAAGCCTCCTGCTGTTCGTGGCCACCTGGGGAATTTCCGGCACACCAGCTCCTCTTGAC
  TCAGTGTTCTCCAGCAGCGAGCGTGCCCACCAGGTGCTGCGGATCCGCAAACGTGCCAAC
  TCCTTCCTGGAGGAGCTCCGTCACAGCAGCCTGGAGCGGGAGTGCATAGAGGAGATCTGT
  GACTTCGAGGAGGCCAAGGAAATTTTCCAAAATGTGGATGACACACTGGCCTTCTGGTCC
  AAGCACGTCGACGGTGACCAGTGCTTGGTCTTGCCCTTGGAGCACCCGTGCGCCAGCCTG
  TGCTGCGGGCACGGCACGTGCATCGACGGCATCGGCAGCTTCAGCTGCGACTGCCGCAGC
  GGCTGGGAGGGCCGCTTCTGCCAGCGCGAGGTGAGCTTCCTCAATTGCTCTCTGGACAAC
  GGCGGCTGCACGCATTACTGCCTAGAGGAGGTGGGCTGGCGGCGCTGTAGCTGTGCGCCT
  GGCTACAAGCTGGGGGACGACCTCCTGCAGTGTCACCCCGCAGTGAAGTTCCCTTGTGGG
  AGGCCCTGGNAAGCGATGGAGAAGAAGCGCAGTCACCTTGAACGAGACACAGAAGACCAA
  GAAGACCAAGTNGATCCGCGGCTCATTGATGGGAAAGATGACCAGCGGNGAGACAGCCCC
  TGGNCAGTGGTCCTGCTGGGACTCAAGAAGAGCTGGCCTGCGGGGCAGTGCTCATCCACC
  CCTCCTGGGTGCTGACAGCGGNCCACTGCATGGATGAGTCCAGAAGCTNCTTGTCAGGCT
  TGGAGAGTATGACCTGCGGCGCNTGGAGAAGTGGGGAGCTGGACCTGNCATCNAGGAGGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000312 unedited
  NTTCCCCCGGTCCTGGNGATGGCACCTNCCAGGNCCAGNGANAGCACTGGGGNAGGGTCA
  CAGGNATGCCACCCGGGATCTGTTCAGAAACAGCTATGACCGCGGCCGCCCTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCCGGGGTTGGGT
  TTTTAATCCTTTTTCAAAAACAAAGTATCCCCCTCAACACACACAGCTTTAAACCCCGCA
  AAACTTGGATCTGCCCCCCCCCCCCCCACAAAGTTGCCCTAGGAGTTAAAATTCTATTCA
  AAAGGCATGTGACATACAACAGGGGCCCAGTAAATGTTACTTCCCCCCAAAAAACCCCAA
  AAAAGGGATGGAAGGACAAAACACCAGGCCGGGGTGCTTGTTACATGTCCCTTTAAGGCC
  CCATCCATTGCCATGCAAAACCCCACCCCTGCAGGGAGGGTCCCTAAGGGGCCCACCCCT
  TCTGGGGGGCTCCCTTGTCCCTGATGTGCCCATGGATCCAGTCCAGGTACCGCCTGACTT
  TGGTGTAAACCCCGTATTTGTGAAGGACCCCACAGCCCTCACCCCAGCTCACCAGGCCCA
  CCAGGAACCAGGTGCCGTGGAAGGAGGCAACCATGGGCCCCCCACTGTCGCCCTCGCAGG
  CATCCTGCCGGTCCCCGAGGATGCCCGCACACAGCATGTTCTCAAACACCATGTTGCCCA
  TGACCCCCCTGCACTCATTGTGCGGGACCACGGGAATCTTGATGAATTTGAGGACCAAGG
  TGCGGTTTCTCTTGGCCTCCTTCTCTCGGCTGCTGTGGTACCCCCAGCCCGTCACGAGGG
  TCTCCTGGCCGGCCTGATTGAGCTCGCGCTCTGCAAGGCCGCTGTCCGGAAGGCAAC
  
• Restriction Sites: Please inquire
• ACCN: NM_000312
• Insert Size: 2000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_000312.1, NP_000303.1
• RefSeq Size: 1843 bp
• RefSeq ORF: 1386 bp
• Locus ID: 5624
• Cytogenetics: 2q14.3
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades
• Gene Summary: 'This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]'