GCAP3 (GUCA1C) (NM_005459) Human Untagged Clone

CAT#: SC303648

GUCA1C (untagged)-Human guanylate cyclase activator 1C (GUCA1C)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GUCA1C
• Synonyms: GCAP3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005459, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGGAATGGCAAATCTATAGCTGGTGATCAGAAAGCAGTTCCTACACAAGAGACCCATGTGTGGTACA
  GAACATTTATGATGGAATATCCATCCGGCCTGCAAACACTACATGAATTTAAGACACTTTTGGGTCTGCA
  AGGTCTGAATCAGAAGGCCAATAAACATATTGATCAAGTTTATAATACCTTTGACACGAACAAGGATGGA
  TTTGTTGACTTTTTGGAGTTTATTGCTGCTGTAAATCTAATCATGCAAGAAAAAATGGAGCAAAAATTAA
  AATGGTATTTTAAGCTGTATGATGCTGATGGAAATGGTTCTATTGACAAAAATGAACTACTGGACATGTT
  CATGGCGGTACAAGCCCTCAATGGCCAGCAAACTCTGAGTCCTGAAGAATTCATCAACTTGGTGTTCCAT
  AAGATCGATATAAACAATGATGGGGAATTGACTTTAGAAGAATTTATCAATGGCATGGCAAAAGATCAGG
  ATCTCCTGGAGATTGTTTACAAGAGCTTCGACTTCTCCAATGTGCTGAGAGTAATCTGTAATGGGAAGCA
  GCCAGACATGGAGACAGACTCCTCCAAATCTCCTGACAAGGCTGGTCTAGGGAAGGTGAAAATGAAGTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_005459
• ORF Size: 630 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005459.3, NP_005450.3
• RefSeq Size: 925
• RefSeq ORF: 630
• Locus ID: 9626
• Protein Pathways: Olfactory transduction
• Gene Summary: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure. [UniProtKB/Swiss-Prot Function]