Laminin (LAMC3) (NM_006059) Human Untagged Clone

CAT#: SC303727

LAMC3 (untagged)-Human laminin, gamma 3 (LAMC3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LAMC3
• Synonyms: OCCM
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006059, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGGCGGCTGCGCTTCTGCTGGGGCTGGCGCTGCTGGCACCGCGGGCGGCCGGCGCGGGCATGGGCG
  CGTGCTATGACGGCGCAGGGCGCCCGCAGCGCTGCCTGCCGGTGTTCGAGAACGCGGCGTTTGGGCGGCT
  CGCCCAGGCCTCGCACACGTGCGGCAGCCCGCCCGAGGACTTCTGTCCCCACGTGGGCGCCGCGGGCGCG
  GGGGCTCATTGCCAGCGCTGCGACGCCGCCGACCCCCAGCGCCACCACAACGCCTCCTACCTCACCGACT
  TCCACAGCCAGGACGAGAGCACCTGGTGGCAGAGCCCGTCCATGGCCTTCGGCGTGCAGTACCCCACCTC
  GGTCAACATCACCCTCCGCCTAGGGAAGGCTTATGAGATCACGTATGTGAGGCTGAAGTTCCACACCAGT
  CGCCCTGAGAGCTTTGCCATCTACAAGCGCAGCCGCGCCGACGGCCCATGGGAGCCCTACCAGTTCTACA
  GCGCCTCCTGCCAGAAGACCTACGGCCGGCCCGAGGGCCAGTACCTGCGCCCCGGCGAGGACGAGCGCGT
  GGCCTTCTGCACCTCTGAGTTCAGCGACATCTCCCCGCTGAGTGGCGGCAACGTGGCCTTCTCCACCCTG
  GAGGGCCGGCCCAGCGCCTACAACTTCGAGGAGAGCCCTGGGCTGCAGGAGTGGGTCACCAGCACCGAAC
  TCCTCATCTCTCTAGACCGGCTCAACACGTTTGGGGACGACATCTTCAAGGACCCCAAGGTGCTCCAGTC
  CTACTATTATGCCGTGTCCGACTTCTCTGTGGGCGGCAGGTGCAAGTGCAACGGGCATGCCAGCGAGTGC
  GGCCCCGACGTGGCAGGCCAGTTGGCCTGCCGGTGCCAGCACAACACCACCGGCACAGACTGTGAGCGCT
  GCCTGCCCTTCTTCCAGGACCGCCCGTGGGCCCGGGGCACCGCCGAGGCTGCCCACGAGTGTCTGCCCTG
  CAACTGCAGTGGCCGCTCCGAGGAATGCACGTTTGATCGGGAGCTCTTCCGCAGCACAGGCCACGGCGGG
  CGCTGTCACCACTGCCGTGACCACACAGCTGGGCCACACTGTGAGCGCTGTCAGGAGAATTTCTATCACT
  GGGACCCGCGGATGCCATGCCAGCCCTGTGACTGCCAGTCGGCAGGCTCCCTACACCTCCAGTGCGATGA
  CACAGGCACCTGCGCCTGCAAGCCCACGGTGACTGGCTGGAAGTGTGACCGCTGTCTGCCCGGGTTCCAC
  TCGCTCAGTGAGGGAGGCTGCAGACCCTGCACTTGCAATCCCGCTGGCAGCCTGGACACCTGTGACCCCC
  GCAGTGGGCGCTGCCCCTGCAAAGAGAATGTGGAAGGCAACCTATGTGACAGATGTCGCCCGGGGACCTT
  TAACCTGCAGCCCCACAATCCAGCTGGCTGCAGCAGCTGTTTCTGCTATGGCCACTCCAAGGTGTGCGCG
  TCCACTGCCCAGTTCCAGGTGCATCACATCCTCAGCGATTTCCACCAGGGAGCCGAAGGCTGGTGGGCCA
  GAAGTGTGGGGGGCTCTGAGCACCCCCCACAATGGAGCCCAAATGGGGTCCTCCTGAGCCCAGAAGACGA
  GGAGGAGCTCACAGCACCAGAGAAGTTCCTGGGAGACCAGCGGTTCAGCTATGGGCAGCCCCTCATACTG
  ACCTTCCGGGTGCCCCCCGGGGACTCCCCACTCCCTGTACAGCTGAGGCTGGAAGGGACAGGCTTGGCCC
  TGTCCCTGAGGCACTCTAGCCTGTCTGGCCCCCAGGATGCCGGGCATCCCAGGGAGGTAGAGCTCAGGTT
  CCACCTGCAGGAGACCTCCGAGGACGTGGCCCCTCCACTGCCCCCCTTCCACTTCCAGCGGCTCCTCGCC
  AACCTGACCAGCCTCCGCCTCCGCGTCAGTCCCGGCCCCAGCCCTGCCGGTCCAGTGTTCCTGACTGAGG
  TCCGGCTCACATCCGCCCGGCCAGGGCTTTCCCCGCCAGCCTCCTGGGTGGAGATTTGTTCATGTCCCAC
  TGGCTACACGGGCCAGTTCTGTGAATCCTGTGCTCCGGGATACAAGAGGGAGATGCCACAGGGGGGTCCC
  TATGCCAGCTGTGTCCCCTGCACCTGTAACCAGCATGGCACCTGTGACCCCAACACAGGGATCTGTGTCT
  GCAGCCACCATACCGAGGGCCCATCCTGTGAACGCTGTTTGCCAGGTTTCTATGGCAACCCTTTCGCGGG
  CCAAGCCGACGACTGCCAGCCCTGTCCCTGCCCTGGCCAGTCGGCCTGTACGACCATCCCAGAGAGCCGG
  GAGGTGGTGTGTACCCACTGCCCCCCGGGCCAGAGAGGGCGGCGCTGTGAGGTCTGTGATGATGGCTTTT
  TTGGGGACCCGCTGGGGCTCTTTGGGCACCCCCAGCCCTGCCACCAGTGCCAGTGTAGCGGGAACGTGGA
  CCCCAATGCCGTGGGCAACTGTGACCCCCTGTCTGGCCACTGCCTGCGCTGCCTGCACAACACCACGGGT
  GACCACTGTGAGCACTGTCAGGAAGGCTTCTACGGGAGCGCCCTGGCCCCTCGACCCGCAGACAAATGCA
  TGCCTTGCAGCTGTCACCCACAGGGCTCGGTCAGTGAGCAGATGCCCTGCGACCCAGTGACAGGCCAATG
  CTCCTGCCTGCCTCATGTGACTGCACGGGACTGCAGCCGCTGCTACCCTGGCTTCTTCGACCTCCAGCCT
  GGGAGGGGCTGCCGGAGCTGCAAGTGTCACCCACTGGGCTCCCAGGAGGACCAGTGCCATCCCAAGACTG
  GACAGTGCACCTGCCGCCCAGGTGTCACAGGCCAGGCCTGTGACAGGTGCCAGCTGGGTTTCTTCGGCTT
  CTCCATCAAGGGCTGCCGGGCCTGCAGGTGCTCCCCACTGGGCGCTGCCTCGGCCCAGTGCCACGAGAAC
  GGCACATGCGTGTGCAGGCCTGGCTTCGAGGGCTACAAATGTGACCGCTGCCACGACAACTTCTTCCTCA
  CGGCAGACGGCACACACTGCCAGCAATGTCCGTCCTGCTACGCCCTGGTGAAGGAGGAGGCAGCCAAGCT
  GAAGGCCAGACTGACTTTGACGGAGGGGTGGCTCCAAGGGTCCGACTGTGGCAGTCCCTGGGGACCACTA
  GACATTCTGCTGGGAGAGGCCCCAAGGGGGGACGTCTACCAGGGCCATCACCTGCTTCCAGGGGCTCGGG
  AAGCCTTCCTGGAGCAGATGATGAGCCTCGAGGGTGCTGTCAAGGCCGCCCGGGAGCAGCTGCAGAGGCT
  GAACAAGGGTGCCCGCTGTGCCCAGGCCGGATCCCAGAAGACCTGCACCCAGCTGGCAGACCTGGAGGCA
  GTGCTGGAGTCCTCGGAAGAGGAGATTCTGCATGCAGCTGCCATTCTCGCGTCTCTGGAGATTCCTCAGG
  AAGGTCCCAGTCAGCCGACCAAATGGAGCCACCTGGCCACAGAGGCCCGTGCCCTCGCCAGGAGCCACAG
  AGACACCGCCACCAAGATCGCAGCCACTGCTTGGAGGGCCCTGCTCGCCTCCAACACCAGCTACGCGCTT
  CTCTGGAATCTGCTGGAGGGAAGGGTGGCCCTAGAGACCCAGCGGGACCTGGAGGACAGGTACCAGGAGG
  TCCAGGCGGCCCAGAAAGCACTGAGGACGGCTGTGGCAGAGGTGCTGCCTGAAGCGGAAAGCGTGTTGGC
  CACCGTGCAGCAAGTTGGCGCAGATACAGCCCCGTACCTGGCCTTGCTGGCTTCCCCGGGAGCTCTGCCT
  CAGAAGTCCCGGGCTGAAGACCTGGGCCTGAAGGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGC
  ACATGGCCACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCTACGGCAAACAGAACCCCT
  CACAAAGCTGCACCAGGAGGCCAGAGCCGCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTG
  ACTGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGGAATGAAGCTGCAGTTTCCCCGGCCCAAGG
  ACCAGGCGGCATTGCAGAGGAAGGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAGAAAGAAGAC
  CAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTCCTCCAGTGCCAAGAAGAAGGGCAGAGAA
  GCAGAGGTGTTGGCCAAGGACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACAGGCGCACC
  GCCGTGCCAGCAGGCTCACCAGCCAGACGCAAGCCACGCTCCAACAGGCGTCCCAGCAGGTGCTGGCGTC
  TGAAGCACGCAGACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCTGAGCGAGATGGAGCAGCAG
  ATCCGGGAATCGCGTATCTCACTGGAGAAGGACATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGT
  CGCTGGACACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGCACTAGAACGCCTGAGGCT
  GCAGCTGGGCTCCCCGGGGTCCTTGCAGAGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAG
  CTGCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCGCGCCGACAAACAGAACCTGGAGGCCATTC
  TGCACAGCCTGCCCGAGAACTGTGCCAGCTGGCAGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_006059
• ORF Size: 4728 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006059.3, NP_006050.3
• RefSeq Size: 6107
• RefSeq ORF: 4728
• Locus ID: 10319
• Protein Pathways: ECM-receptor interaction, Focal adhesion, Pathways in cancer, Small cell lung cancer
• Gene Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]