Cezanne (OTUD7B) (NM_020205) Human Untagged Clone

CAT#: SC304721

OTUD7B (untagged)-Human OTU domain containing 7B (OTUD7B)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: OTUD7B
• Synonyms: CEZANNE; ZA20D1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_020205, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACCCTGGACATGGATGCTGTTCTGTCAGATTTTGTCCGTTCCACAGGAGCAGAGCCAGGGCTAGCGC
  GAGATCTCCTAGAAGGAAAGAATTGGGATGTGAATGCCGCCCTCAGTGATTTTGAACAGCTACGTCAAGT
  CCATGCTGGAAACCTACCCCCATCCTTTAGTGAGGGGAGTGGTGGCTCCAGGACCCCTGAAAAAGGGTTT
  TCTGACAGAGAGCCTACTCGCCCTCCCCGACCCATCCTCCAGCGGCAGGATGACATCGTTCAAGAAAAAC
  GCCTGTCTAGGGGCATCTCCCACGCCAGCTCCAGCATTGTTTCCCTGGCCCGGTCCCATGTCTCCTCCAA
  TGGTGGGGGTGGGGGGAGCAATGAGCACCCCCTGGAAATGCCCATCTGTGCCTTCCAGCTTCCAGATCTC
  ACTGTATACAATGAAGACTTCCGCAGCTTCATAGAGAGAGACCTCATTGAGCAGTCCATGCTGGTTGCCT
  TGGAACAGGCAGGGCGTTTGAACTGGTGGGTGAGTGTGGATCCCACCTCTCAGAGGCTGCTTCCTTTGGC
  AACTACTGGAGATGGGAACTGCCTCCTGCATGCAGCCTCCCTTGGAATGTGGGGTTTCCATGATCGGGAC
  TTGATGCTGCGGAAAGCTTTGTATGCACTGATGGAGAAGGGAGTTGAGAAGGAAGCGTTGAAAAGGCGCT
  GGAGGTGGCAGCAGACACAGCAGAATAAAGAGTCAGGGCTGGTATACACAGAAGATGAATGGCAGAAGGA
  GTGGAATGAACTGATCAAGCTTGCCTCAAGTGAACCCCGAATGCATCTAGGTACCAATGGAGCCAACTGT
  GGTGGGGTGGAGAGTTCTGAGGAGCCTGTATATGAGAGCCTTGAAGAGTTTCACGTCTTTGTCCTTGCTC
  ATGTGCTTAGGAGGCCCATAGTCGTCGTGGCAGACACCATGCTGAGGGACTCCGGAGGGGAAGCATTTGC
  CCCTATTCCCTTTGGAGGAATCTATCTGCCTTTGGAGGTCCCAGCCAGCCAGTGTCACCGCTCCCCTCTG
  GTGCTCGCCTATGATCAGGCCCACTTTTCTGCACTCGTGTCCATGGAGCAGAAGGAGAATACCAAGGAAC
  AAGCTGTGATCCCACTTACAGATTCAGAGTATAAGCTGCTGCCCTTGCACTTTGCTGTGGACCCTGGAAA
  GGGCTGGGAGTGGGGCAAAGATGATAGTGACAATGTCCGATTGGCCAGTGTAATTCTGTCCCTAGAGGTC
  AAATTGCATCTGCTGCATAGCTACATGAATGTGAAGTGGATCCCACTGTCCTCTGATGCACAGGCTCCTC
  TGGCCCAGCCTGAGTCCCCCACCGCCTCAGCTGGAGATGAGCCCCGGTCCACTCCTGAGTCTGGAGACTC
  AGACAAGGAGTCAGTTGGCAGCAGTTCCACCAGCAACGAGGGCGGCCGGCGGAAGGAGAAGTCAAAGCGA
  GATCGGGAGAAGGACAAGAAGAGAGCAGATTCTGTGGCTAACAAACTGGGCAGCTTTGGCAAAACCTTGG
  GCAGCAAGCTCAAGAAGAACATGGGGGGCCTGATGCACAGCAAGGGTTCAAAGCCTGGAGGGGTGGGGAC
  AGGGTTGGGAGGAAGCAGCGGCACTGAGACACTGGAGAAGAAGAAGAAAAACTCACTGAAGAGCTGGAAG
  GGTGGCAAGGAGGAGGCAGCTGGGGATGGGCCTGTGTCTGAGAAGCCCCCAGCTGAGTCTGTTGGTAACG
  GAGGGAGCAAGTATAGCCAGGAGGTGATGCAGAGCCTGAGCATTCTGAGGACTGCCATGCAAGGGGAGGG
  GAAGTTTATTTTTGTTGGAACCCTGAAGATGGGTCACCGTCACCAGTATCAGGAGGAAATGATCCAGCGC
  TACCTTTCTGATGCTGAGGAGAGATTCCTGGCAGAACAGAAGCAGAAGGAGGCAGAGAGGAAGATCATGA
  ATGGAGGAATAGGGGGTGGCCCTCCTCCAGCCAAAAAGCCAGAGCCAGATGCTAGGGAAGAGCAGCCGAC
  CGGTCCCCCAGCAGAGTCCAGGGCAATGGCATTTTCCACTGGCTACCCTGGGGACTTTACTATCCCTCGG
  CCGTCTGGGGGCGGAGTCCACTGCCAGGAACCCCGGAGGCAGTTGGCAGGGGGTCCATGTGTCGGGGGCC
  TACCACCATATGCCACCTTCCCCAGACAGTGCCCTCCTGGGCGACCCTACCCCCACCAGGACAGCATCCC
  TTCTCTGGAGCCAGGCAGCCACTCTAAGGATGGACTTCACAGGGGTGCCTTGTTACCACCCCCCTACCGA
  GTGGCTGATTCCTATAGCAATGGCTACAGAGAGCCCCCTGAGCCAGATGGATGGGCTGGAGGTCTCCGGG
  GCCTTCCCCCAACTCAGACCAAATGCAAACAACCGAACTGCAGCTTCTATGGACACCCTGAGACAAACAA
  CTTCTGTTCCTGTTGTTACAGGGAAGAACTGAGGAGGAGGGAGCGGGAACCGGATGGGGAGCTCCTGGTG
  CACAGGTTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_020205
• ORF Size: 2532 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_020205.3, NP_064590.2
• RefSeq Size: 6415
• RefSeq ORF: 2532
• Locus ID: 56957
• Gene Summary: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProtKB/Swiss-Prot Function]