MVB12B (NM_033446) Human Untagged Clone

CAT#: SC305635

MVB12B (untagged)-Human family with sequence similarity 125, member B (FAM125B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MVB12B
• Synonyms: C9orf28; FAM125B
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_033446, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGAAGCTGCTTCTGCGTGAGACGGAGCCGGGACCCGCCGCCGCCGCAGCCACCGCCGCCGCCGCCCC
  AGCGGGGAACAGACCAGTCCACCATGCCTGAAGTCAAAGACCTCTCAGAAGCCTTGCCAGAAACGTCAAT
  GGATCCCATCACGGGAGTCGGGGTGGTGGCTTCTCGGAACCGAGCCCCGACAGGCTATGACGTAGTTGCA
  CAGACAGCAGATGGTGTGGATGCTGACCTCTGGAAAGACGGCTTATTTAAATCCAAGGTTACCAGATACC
  TGTGTTTCACAAGATCATTTTCCAAAGAAAATAGTCATCTGGGGAACGTGTTAGTAGATATGAAGCTCAT
  TGACATCAAGGACACACTGCCTGTGGGCTTCATCCCAATTCAGGAGACGGTGGACACACAGGAAGTGGCT
  TTTAGGAAGAAGAGGCTGTGCATTAAATTTATTCCACGGGATTCAACGGAAGCTGCGATTTGTGACATTC
  GGATCATGGGCCGGACCAAGCAGGCCCCGCCTCAGTACACGTTTATTGGGGAACTGAACAGCATGGGGAT
  CTGGTATCGAATGGGCAGAGTACCAAGAAATCATGACTCATCTCAACCCACAACGCCTTCCCAGTCATCA
  GCTGCCTCCACCCCAGCCCCCAACCTTCCCAGGCACATCTCCCTAACACTTCCTGCCACCTTCCGAGGCA
  GGAACAGCACCCGGACGGACTACGAGTACCAGCACTCCAATTTGTATGCCATATCAGCAATGGATGGTGT
  GCCTTTTATGATTTCAGAGAAGTTTTCTTGTGTTCCAGAAAGTATGCAGCCCTTTGATCTCCTGGGAATC
  ACCATCAAATCTCTAGCAGAAATCGAAAAAGAGTACGAGTACAGCTTCCGCACAGAGCAGAGCGCAGCCG
  CCAGGCTCCCGCCCAGCCCCACCAGGTGTCAGCAGATCCCGCAGTCCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_033446
• ORF Size: 960 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_033446.2, NP_258257.1
• RefSeq Size: 4842
• RefSeq ORF: 960
• Locus ID: 89853
• Protein Pathways: Endocytosis
• Gene Summary: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).