GPR113 (ADGRF3) (NM_153835) Human Untagged Clone

CAT#: SC306667

GPR113 (untagged)-Human G protein-coupled receptor 113 (GPR113), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADGRF3
• Synonyms: GPR113; PGR23
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_153835, the custom clone sequence may differ by one or more nucleotides
  ATGACGACCCGAAAACTGAGCGCCCACTCGGCAGCGACTCCCGGCTACAAGGCTGTGACA
  CACAAGCACCACACCGGCTGGGCAAGGATGGCAAAGACTGGGCTGCCCGAGAAGGGACAG
  AGTCAGGCTGGAGGGGAATCTGGATCTGGGCAGCTCCTGGACCAAGAGAATGGAGCAGGG
  GAATCAGCGCTGGTCTCCGTCTATGTACATCTGGACTTTCCAGATAAGACCTGGCCCCCT
  GAACTCTCCAGGACACTGACTCTCCCTGCTGCCTCAGCTTCCTCTTCCCCAAGGCCTCTT
  CTCACTGGCCTCAGACTCACAACAGGTGAGTACATGAGCTGCTTCGAGGCCCAGGGCTTC
  AAGTGGAACCTGTATGAGGTGGTGAGGGTGCCCTTGAAGGCGACAGATGTGGCTCGACTT
  CCATACCAGCTGTCCATCTCCTGTGCCACCTCCCCTGGCTTCCAGCTGAGCTGCTGCATC
  CCCAGCACAAACCTGGCCTACACCGCGGCCTGGAGCCCTGGAGAGGGCAGCAAAGCTTCC
  TCCTTCAACGAGTCAGGCTCTCAGTGCTTTGTGCTGGCTGTTCAGCGCTGCCCGATGGCT
  GACACCACGTACGCTTGTGACCTGCAGAGCCTGGGCCTGGCTCCACTCAGGGTCCCCATC
  TCCATCACCATCATCCAGGATGGAGACATCACCTGCCCTGAGGACGCCTCGGTGCTCACC
  TGGAATGTCACCAAGGCTGGCCACGTGGCACAGGCCCCATGTCCTGAGAGCAAGAGGGGC
  ATAGTGAGGAGGCTCTGTGGGGCTGACGGAGTCTGGGGGCCGGTCCACAGCAGCTGCACA
  GATGCGAGGCTCCTGGCCTTGTTCACTAGAACCAAGCTGCTGCAGGCAGGCCAGGGCAGT
  CCTGCTGAGGAGGTGCCACAGATCCTGGCACAGCTGCCAGGGCAGGCGGCAGAGGCAAGT
  TCACCCTCCGACTTACTGACCCTGCTGAGCACCATGAAATACGTGGCCAAGGTGGTGGCA
  GAGGCCAGAATACAGCTTGACCGCAGAGCCCTGAAGAATCTCCTGATTGCCACAGACAAG
  GTCCTAGATATGGACACCAGGTCTCTGTGGACCCTGGCCCAAGCCCGGAAGCCCTGGGCA
  GGCTCGACTCTCCTGCTGGCTGTGGAGACCCTGGCATGCAGCCTGTGCCCACAGGACCAC
  CCCTTCGCCTTCAGCTTACCCAATGTGCTGCTGCAGAGCCAGCTGTTTGGACCCACGTTT
  CCTGCTGACTACAGCATCTCCTTCCCTACTCGGCCCCCACTGCAGGCTCAGATTCCCAGG
  CACTCACTGGCCCCATTGGTCCGTAATGGAACTGAAATAAGTATTACTAGCCTGGTGCTG
  CGAAAACTGGACCACCTTCTGCCCTCAAACTATGGACAAGGGCTGGGGGATTCCCTCTAT
  GCCACTCCTGGCCTGGTCCTTGTCATTTCCATCATGGCAGGTGACCGGGCCTTCAGCCAG
  GGAGAGGTCATCATGGACTTTGGGAACACAGATGGTTCCCCTCACTGTGTCTTCTGGGAT
  CACAGTCTCTTCCAGGGCAGGGGGGGTTGGTCCAAAGAAGGGTGCCAGGCACAGGTGGCC
  AGTGCCAGCCCCACTGCTCAGTGCCTCTGCCAGCACCTCACTGCCTTCTCCGTCCTCATG
  TCCCCACACACTGTTCCGGAAGAACCCGCTCTGGCGCTGCTGACTCAAGTGGGCTTGGGA
  GCTTCCATACTGGCGCTGCTTGTGTGCCTGGGTGTGTACTGGCTGGTGTGGAGAGTCGTG
  GTGCGGAACAAGATCTCCTATTTCCGCCACGCCGCCCTGCTCAACATGGTGTTCTGCTTG
  CTGGCCGCAGACACTTGCTTCCTGGGCGCCCCATTCCTCTCTCCAGGGCCCCGAAGCCCG
  CTCTGCCTTGCTGCCGCCTTCCTCTGTCATTTCCTCTACCTGGCCACCTTTTTCTGGATG
  CTGGCGCAGGCCCTGGTGTTGGCCCACCAGCTGCTCTTTGTCTTTCACCAGCTGGCAAAG
  CACCGAGTTCTCCCCCTCATGGTGCTCCTGGGCTACCTGTGCCCACTGGGGTTGGCAGGT
  GTCACCCTGGGGCTCTACCTACCTCAAGGGCAATACCTGAGGGAGGGGGAATGCTGGTTG
  GATGGGAAGGGAGGGGCGTTATACACCTTCGTGGGGCCAGTGCTGGCCATCATAGGCGTG
  AATGGGCTGGTACTAGCCATGGCCATGCTGAAGTTGCTGAGACCTTCGCTGTCAGAGGGA
  CCCCCAGCAGAGAAGCGCCAAGCTCTGCTGGGGGTGATCAAAGCCCTGCTCATTCTTACA
  CCCATCTTTGGCCTCACCTGGGGGCTGGGCCTGGCCACTCTGTTAGAGGAAGTCTCCACG
  GTCCCTCATTACATCTTCACCATTCTCAACACCCTCCAGGGCGTCTTCATCCTATTGTTT
  GGTTGCCTCATGGACAGGAAGATACAAGAAGCTTTGCGCAAACGCTTCTGCCGCGCCCAA
  GCCCCCAGCTCCACCATCTCCCTGGCCACAAATGAAGGCTGCATCTTGGAACACAGCAAA
  GGAGGAAGCGACACTGCCAGGAAGACAGATGCTTCAGAGTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_153835
• ORF Size: 3240 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_153835.1, NP_722577.1
• RefSeq Size: 3240
• RefSeq ORF: 3240
• Locus ID: 165082
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Orphan receptor. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (3) has alternate 5' and 3' sequences and lacks two internal in-frame coding exons, as compared to variant 1. The resulting isoform (3) has shorter and different N- and C-termini and lack an internal segment, as compared to isoform 1. CCDS Note: There is only one full-length mRNA, AY358172.1, that supports this CCDS splice variant although it is different at the 3' end. The 3' end of AY358172.1 would cause it to be an NMD candidate. The 3' end is supported by BC043211.1, AK122995.1 and AY358214.1 although these have extra internal exons that are not in the RefSeq. Mouse ESTs, BB730166.1 and BB728829.1, support the 3' end. Human ESTs, BI559800.1, DC308501.1, and BX118758.1, show support for some splice sites but also include additional exons. The protein encoded by this CCDS contains intact PFAM Latrophilin/CL-1-like GPS (GPS) and the 7 transmembrane receptor (Secretin family) (7tm_2) domains. Given the current evidence at this locus, this is the best variant that can be represented; this could change with future transcript evidence. It seems that a combination of AY358172.1 5' and 3' ends and the inclusion of the extra AY140955.1 exons in the middle could also create a valid splice variant but there is not enough evidence for this at this time.