EYA4 (NM_172105) Human Untagged Clone

CAT#: SC306719

EYA4 (untagged)-Human eyes absent homolog 4 (Drosophila) (EYA4), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EYA4
• Synonyms: CMD1J; DFNA10
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_172105, the custom clone sequence may differ by one or more nucleotides
  ATGGAAGACTCCCAGGATTTAAATGAACAATCAGTAAAGAAAACGTGCACAGAATCAGAT
  GTTTCACAATCTCAGAATTCCAGGTCTATGGAAATGCAGGACCTAGCAAGTCCTCATACT
  CTTGTTGGAGGTGGTGATACTCCAGGTAGCTCCAAACTGGAAAAATCTAATCTCAGCAGC
  ACATCAGTTACTACAAATGGGACAGGAGGGGAAAACATGACTGTTTTAAACACAGCAGAC
  TGGTTGCTGAGTTGCAACACCCCCTCTTCTGCAACAATGTCTCTTCTTGCAGTCAAAACA
  GAGCCCTTGAACAGCAGTGAAACCACAGCCACGACTGGAGATGGAGCGCTTGACACTTTT
  ACTGGGTCAGTAATTACAAGTAGTGGCTACAGCCCCAGATCAGCACATCAGTATTCCCCA
  CAGCTGTATCCTTCCAAGCCCTATCCACACATTCTTTCTACACCAGCAGCTCAAACAATG
  TCTGCCTATGCAGGCCAGACTCAGTATTCGGGGATGCAGCAGCCAGCCGTCTACACAGCC
  TACTCACAGACAGGACAGCCCTACAGCTTGCCCACTTACGATTTGGGTGTGATGTTGCCA
  GCCATCAAGACAGAGAGTGGACTTTCCCAAACTCAGTCCCCATTACAGAGTGGCTGCCTC
  AGTTACAGCCCAGGGTTCTCTACCCCACAGCCAGGCCAGACACCTTATTCTTACCAAATG
  CCAGGTTCTAGTTTTGCACCATCATCTACTATTTATGCAAATAATTCAGTTTCCAATTCA
  ACGAATTTCAGTGGTTCACAACAGGATTATCCATCCTATACAGCCTTTGGCCAAAACCAG
  TATGCACAGTATTATTCAGCATCAACGTATGGAGCGTATATGACATCGAATAACACAGCC
  GATGGCACACCCTCTTCAACCTCTACTTATCAGTTGCAGGAATCTCTCCCAGGACTGACT
  AACCAACCAGGAGAGTTCGATACCATGCAGAGTCCCTCCACACCCATCAAAGATCTTGAT
  GAGAGAACCTGTAGGAGTTCTGGGTCAAAGTCCAGAGGAAGAGGCCGGAAAAATAATCCC
  TCCCCGCCTCCTGATAGTGACCTGGAGCGTGTGTTTGTCTGGGATTTGGATGAAACCATC
  ATTGTTTTTCACTCACTGCTCACCGGGTCTTATGCACAGAAGTATGGCAAGGATCCCCCC
  ATGGCTGTAACCCTTGGACTCCGCATGGAAGAAATGATTTTTAATCTTGCTGATACTCAT
  TTGTTTTTTAATGATTTAGAGGAGTGTGATCAAGTTCATATAGATGATGTTTCCTCTGAT
  GATAATGGGCAGGACTTAAGTACCTACAGTTTTGCAACTGATGGCTTCCATGCAGCTGCA
  AGTAGTGCAAACCTTTGTTTGCCAACAGGTGTAAGAGGAGGGGTTGACTGGATGAGGAAG
  TTGGCTTTTCGTTACAGAAGAGTAAAAGAATTATATAACACCTACAAGAACAACGTTGGA
  GGACTCCTTGGCCCTGCCAAGAGGGATGCCTGGCTACAGTTAAGGGCAGAGATTGAAGGT
  CTGACAGATTCCTGGCTAACAAATGCACTTAAGTCTTTATCAATTATTAGCACTAGGAGT
  AACTGCATAAATGTCTTGGTAACGACAACTCAACTGATCCCAGCACTTGCGAAGGTTCTA
  CTCTATAGTTTAGGAGGTGCTTTCCCCATTGAGAATATTTACAGTGCAACTAAAATAGGC
  AAGGAAAGCTGTTTTGAGCGTATAGTGTCCAGATTTGGCACTAACATAACTTATGTTGTG
  ATTGGAGATGGCCGAGATGAGGAGCATGCCGCTAACCAGCACAACATGCCCTTCTGGAGG
  ATATCCAGTCACTCAGACCTCCTGGCTCTCCACCAAGCACTGGAATTAGAGTATTTGTAA
  
• Restriction Sites: Please inquire
• ACCN: NM_172105
• ORF Size: 1920 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_172105.1, NP_742103.1
• RefSeq Size: 3077
• RefSeq ORF: 1920
• Locus ID: 2070
• Protein Families: Druggable Genome, Phosphatase, Transcription Factors
• Gene Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
  Transcript Variant: This variant (4) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (d) is the same size but has a region of difference in the C-terminal, compared to isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.