YTHDC2 (NM_022828) Human Untagged Clone

CAT#: SC308805

YTHDC2 (untagged)-Human YTH domain containing 2 (YTHDC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: YTHDC2
• Synonyms: CAHL; hYTHDC2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022828, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGTCCAGGCCGAGCAGCGTCTCCCCGCGGCAGCCGGCTCCTGGCGGTGGCGGAGGCGGCGGCCCCTCGC
  CTTGTGGCCCTGGGGGCGGCGGCCGGGCCAAGGGGCTGAAGGACATTCGCATTGATGAGGAGGTGAAGAT
  CGCAGTCAATATCGCGCTGGAGCGCTTCCGATACGGGGACCAGAGAGAAATGGAATTTCCTTCTTCTTTG
  ACCAGTACTGAAAGAGCCTTTATTCATCGACTCAGTCAGTCTCTTGGTTTGGTCTCTAAAAGTAAAGGAA
  AGGGAGCAAATAGATACCTAACTGTGAAGAAGAAAGATGGATCAGAAACAGCTCATGCAATGATGACCTG
  TAATTTGACTCATAATACAAAACATGCTGTTAGGAGCCTAATTCAAAGATTTCCTGTCACCAATAAAGAG
  CGTACAGAACTTCTGCCTAAAACAGAAAGAGGAAATGTGTTTGCAGTTGAAGCTGAAAACCGGGAAATGA
  GCAAGACAAGTGGGCGACTCAACAATGGCATACCTCAGATTCCAGTGAAAAGAGGAGAATCCGAATTTGA
  TTCTTTTAGGCAGTCTTTACCAGTGTTTGAGAAACAGGAAGAAATTGTTAAAATAATTAAGGAAAATAAA
  GTAGTTTTGATTGTAGGAGAAACTGGGTCTGGAAAGACCACACAGATTCCTCAGTTCCTTTTAGATGATT
  GCTTTAAAAATGGTATCCCCTGCCGTATATTTTGTACTCAACCAAGACGATTGGCAGCTATCGCTGTGGC
  TGAAAGAGTTGCCGCAGAGAGACGGGAAAGGATTGGTCAAACAATTGGTTATCAGATCCGATTAGAAAGC
  AGGGTTTCTCCAAAGACACTTCTGACATTTTGTACTAATGGGGTATTGCTTCGTACATTGATGGCAGGAG
  ATAGTACGTTGTCGACTGTGACACATGTTATCGTGGATGAAGTGCATGAAAGGGATCGATTTAGTGATTT
  TTTACTTACAAAGTTAAGAGATTTGTTGCAAAAGCACCCAACTTTGAAACTAATTCTTTCTAGTGCTGCC
  TTGGATGTAAATCTCTTTATAAGATATTTTGGAAGTTGTCCAGTGATATATATACAGGGAAGACCATTTG
  AAGTAAAAGAAATGTTTCTGGAAGATATTTTAAGAACAACTGGATATACAAACAAAGAAATGTTAAAATA
  TAAAAAGGAAAAACAGCAAGAAGAGAAACAACAAACCACACTTACAGAATGGTACTCAGCTCAAGAAAAT
  AGTTTCAAGCCTGAATCTCAGAGGCAGAGAACTGTTCTAAATGTGACTGATGAGTATGACTTACTGGATG
  ATGGTGGTGATGCTGTCTTCAGTCAGCTGACTGAAAAAGATGTGAATTGCCTTGAACCATGGTTAATAAA
  GGAAATGGATGCTTGCCTTTCTGATATATGGCTACATAAAGATATTGATGCCTTTGCTCAGGTCTTTCAT
  CTCATTTTAACTGAAAATGTTAGTGTTGATTACAGACATAGTGAAACCAGTGCAACAGCTCTGATGGTTG
  CTGCAGGACGTGGCTTTGCAAGTCAAGTAGAACAGTTAATCAGTATGGGAGCCAATGTCCATAGTAAAGC
  ATCAAATGGCTGGATGGCATTGGATTGGGCTAAACACTTTGGGCAGACTGAAATTGTGGATCTTCTAGAA
  TCTTACAGTGCTACACTGGAATTTGGAAATCTAGATGAAAGTTCTCTGGTTCAAACAAATGGAAGTGACC
  TCAGTGCTGAAGACAGAGAGCTCCTGAAAGCTTATCATCATAGTTTCGATGATGAAAAAGTAGACTTGGA
  TTTGATCATGCATCTTCTATACAATATCTGCCATAGTTGTGATGCTGGTGCAGTACTAATTTTTCTGCCT
  GGATATGACGAAATTGTTGGACTGAGAGATCGCATCCTGTTTGATGACAAGCGGTTTGCTGACAGTACAC
  ATAGATACCAAGTCTTTATGCTTCATTCAAATATGCAAACATCCGATCAAAAGAAAGTATTAAAAAACCC
  ACCTGCAGGTGTTCGAAAAATAATTCTTTCCACCAATATTGCTGAAACCAGCATCACAGTCAATGATGTT
  GTCTTTGTTATTGATTCTGGTAAGGTGAAAGAGAAATCCTTTGATGCTCTGAATTTTGTTACAATGTTAA
  AAATGGTATGGATTTCCAAAGCTAGTGCCATACAGCGGAAAGGCAGGGCAGGGCGATGTAGACCTGGAAT
  TTGTTTTCGTCTGTTCAGTAGACTCCGATTCCAGAATATGTTGGAATTTCAGACTCCGGAACTTTTGAGA
  ATGCCATTACAGGAACTTTGCTTACATACCAAGCTGTTAGCCCCAGTTAATTGTCCCATTGCTGATTTTC
  TTATGAAAGCTCCTGAACCTCCACCAGCTTTAATTGTAAGAAATGCTGTACAAATGCTTAAGACAATAGA
  TGCAATGGATACATGGGAAGATCTGACTGAACTTGGGTATCATTTGGCTGACTTGCCAGTAGAACCACAT
  CTTGGTAAAATGGTCTTGTGTGCTGTTGTTTTAAAGTGTCTGGACCCCATCCTTACAATTGCTTGCACAC
  TAGCTTATCGAGATCCTTTTGTACTACCTACTCAGGCCTCTCAAAAACGTGCAGCTATGCTTTGTAGGAA
  ACGTTTTACTGCAGGAGCTTTCAGTGACCATATGGCACTTCTCAGAGCATTCCAGGCCTGGCAAAAAGCA
  CGAAGTGATGGGTGGGAGCGAGCCTTTTGTGAAAAGAATTTTCTTTCACAGGCTACTATGGAAATAATCA
  TAGGCATGAGAACACAGTTGCTTGGTCAACTTAGAGCATCAGGTTTTGTTAGAGCACGAGGTGGTGGTGA
  CATTCGGGACGTTAACACAAACTCTGAGAATTGGGCTGTCGTTAAAGCTGCATTGGTGGCAGGCATGTAT
  CCTAATTTAGTCCACGTGGACAGAGAGAATCTAGTGTTGACAGGGCCAAAGGAGAAAAAAGTACGATTTC
  ATCCTGCTTCAGTTCTCAGTCAGCCTCAATATAAAAAGATTCCTCCAGCCAATGGTCAAGCTGCAGCAAT
  TAAGGCACTGCCCACAGATTGGCTTATTTATGATGAAATGACCAGAGCCCATAGAATAGCTAATATTAGA
  TGTTGTTCAGCAGTGACGCCTGTCACTATATTGGTATTCTGTGGACCAGCTAGATTGGCAAGTAATGCTC
  TTCAGGAACCTTCATCCTTTAGAGTGGATGGCATTCCCAATGACAGTAGTGATAGTGAAATGGAGGACAA
  AACTACAGCTAATTTGGCAGCCTTGAAACTTGATGAGTGGCTCCATTTCACACTGGAGCCAGAGGCAGCT
  AGTTTATTGCTGCAGCTCAGACAGAAGTGGCATAGCTTATTTTTACGCCGAATGAGAGCTCCATCTAAAC
  CTTGGTCTCAAGTTGATGAAGCTACCATAAGAGCAATTATAGCTGTTTTAAGCACTGAAGAACAGTCTGC
  AGGTTTACAACAACCATCTGGGATTGGCCAAAGGCCAAGGCCTATGTCTTCAGAAGAGCTTCCTTTGGCC
  TCATCTTGGAGGTCAAATAATAGTAGGAAAAGTTCAGCAGATACTGAATTTTCTGATGAGTGTACTACTG
  CAGAAAGAGTACTGATGAAATCTCCATCTCCAGCATTACACCCACCTCAGAAGTACAAAGATAGAGGAAT
  TTTACATCCTAAACGAGGTACTGAGGACCGATCAGATCAGTCTTCTCTGAAATCTACAGACAGCAGTAGT
  TACCCAAGTCCTTGTGCTAGTCCTTCTCCTCCATCCTCAGGAAAGGGCTCAAAATCTCCTTCGCCAAGAC
  CAAACATGCCTGTTCGATACTTCATAATGAAGAGTAGCAATTTGAGAAACCTTGAAATTTCTCAACAGAA
  GGGTATCTGGTCTACAACTCCTAGTAATGAACGGAAGCTAAATCGAGCCTTTTGGGAAAGCAGCATAGTT
  TACTTGGTATTTTCTGTTCAAGGATCTGGACATTTCCAGGGATTTTCTAGGATGTCTTCTGAGATTGGAA
  GGGAAAAGAGTCAGGACTGGGGCTCTGCTGGACTAGGAGGAGTATTTAAGGTGGAGTGGATACGAAAAGA
  AAGCCTTCCCTTTCAATTTGCACACCATTTACTCAATCCATGGAATGACAACAAGAAAGTGCAGATAAGC
  AGGGATGGGCAGGAACTAGAACCTCTGGTTGGTGAACAGTTGCTCCAGTTATGGGAACGTCTTCCCTTGG
  GAGAAAAAAACACAACTGATTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_022828
• ORF Size: 4293 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_022828.3, NP_073739.3
• RefSeq Size: 6308
• RefSeq ORF: 4293
• Locus ID: 64848
• Domains: YTH, HA2
• Gene Summary: This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.