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Utrophin (UTRN) (NM_007124) Human Untagged Clone
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Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Symbol | UTRN |
| Synonyms | DMDL; DRP; DRP1 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>NCBI ORF sequence for NM_007124, the custom clone sequence may differ by one or more nucleotides
ATGGCCAAGTATGGAGAACATGAAGCCAGTCCTGACAATGGGCAGAACGAATTCAGTGATATCATTAAGT CCAGATCTGATGAACACAATGACGTACAGAAGAAAACCTTTACCAAATGGATAAATGCTCGATTTTCAAA GAGTGGGAAACCACCCATCAATGATATGTTCACAGACCTCAAAGATGGAAGGAAGCTATTGGATCTTCTA GAAGGCCTCACAGGAACATCACTGCCAAAGGAACGTGGTTCCACAAGGGTACATGCCTTAAATAACGTCA ACAGAGTGCTGCAGGTTTTACATCAGAACAATGTGGAATTAGTGAATATAGGGGGAACTGACATTGTGGA TGGAAATCACAAACTGACTTTGGGGTTACTTTGGAGCATCATTTTGCACTGGCAGGTGAAAGATGTCATG AAGGATGTCATGTCGGACCTGCAGCAGACGAACAGTGAGAAGATCCTGCTCAGCTGGGTGCGTCAGACCA CCAGGCCCTACAGCCAAGTCAACGTCCTCAACTTCACCACCAGCTGGACAGATGGACTCGCCTTTAATGC TGTCCTCCACCGACATAAACCTGATCTCTTCAGCTGGGATAAAGTTGTCAAAATGTCACCAATTGAGAGA CTTGAACATGCCTTCAGCAAGGCTCAAACTTATTTGGGAATTGAAAAGCTGTTAGATCCTGAAGATGTTG CCGTTCAGCTTCCTGACAAGAAATCCATAATTATGTATTTAACATCTTTGTTTGAGGTGCTACCTCAGCA AGTCACCATAGACGCCATCCGTGAGGTAGAGACACTCCCAAGGAAATATAAAAAAGAATGTGAAGAAGAG GCAATTAATATACAGAGTACAGCGCCTGAGGAGGAGCATGAGAGTCCCCGAGCTGAAACTCCCAGCACTG TCACTGAGGTTGACATGGATCTGGACAGCTATCAGATTGCGTTGGAGGAAGTGCTGACCTGGTTGCTTTC TGCTGAGGACACTTTCCAGGAGCAGGATGATATTTCTGATGATGTTGAAGAAGTCAAAGACCAGTTTGCA ACCCATGAAGCTTTTATGATGGAACTGACTGCACACCAGAGCAGTGTGGGCAGCGTCCTGCAGGCAGGCA ACCAACTGATAACACAAGGAACTCTGTCAGACGAAGAAGAATTTGAGATTCAGGAACAGATGACCCTGCT GAATGCTAGATGGGAGGCTCTTAGGGTGGAGAGTATGGACAGACAGTCCCGGCTGCACGATGTGCTGATG GAACTGCAGAAGAAGCAACTGCAGCAGCTCTCCGCCTGGTTAACACTCACAGAGGAGCGCATTCAGAAGA TGGAAACTTGCCCCCTGGATGATGATGTAAAATCTCTACAAAAGCTGCTAGAAGAACATAAAAGTTTGCA AAGTGATCTTGAGGCTGAACAGGTGAAAGTAAATTCACTAACTCACATGGTGGTCATTGTTGATGAAAAC AGTGGTGAGAGTGCTACAGCTATCCTAGAAGACCAGTTACAGAAACTTGGTGAGCGCTGGACAGCAGTAT GCCGTTGGACTGAAGAACGCTGGAATAGGTTACAAGAAATCAATATATTGTGGCAGGAATTATTGGAAGA ACAGTGCTTGTTGAAAGCTTGGTTAACCGAAAAAGAAGAGGCTTTAAATAAAGTCCAGACAAGCAACTTC AAAGACCAAAAGGAACTAAGTGTCAGTGTTCGACGTCTGGCTATTTTGAAGGAAGACATGGAAATGAAGC GTCAAACATTGGATCAGCTGAGTGAGATTGGCCAGGATGTGGGACAATTACTTGATAATTCCAAGGCATC TAAGAAGATCAACAGTGACTCAGAGGAACTGACTCAAAGATGGGATTCTTTGGTTCAGAGACTAGAAGAT TCCTCCAACCAGGTGACTCAGGCTGTAGCAAAGCTGGGGATGTCTCAGATTCCTCAGAAGGACCTTTTGG AGACTGTTCGTGTAAGAGAACAAGCAATTACAAAAAAATCTAAGCAGGAACTGCCTCCTCCTCCTCCCCC AAAGAAGAGACAGATCCATGTGGATATTGAAGCTAAGAAAAAGTTTGATGCTATAAGTGCAGAGCTGTTG AACTGGATTTTGAAATGGAAAACTGCCATTCAGACCACAGAGATAAAAGAGTATATGAAGATGCAAGACA CTTCCGAAATGAAAAAGAAGTTGAAGGCATTAGAAAAAGAACAGAGAGAAAGAATCCCCAGAGCAGATGA ATTAAACCAAACTGGACAAATCCTTGTGGAGCAAATGGGAAAAGAAGGCCTTCCTACTGAAGAAATAAAA AATGTTCTGGAGAAGGTTTCATCAGAATGGAAGAATGTATCTCAACATTTGGAAGATCTAGAAAGAAAGA TTCAGCTACAGGAAGATATAAATGCTTATTTCAAGCAGCTTGATGAGCTTGAAAAGGTCATCAAGACAAA GGAGGAGTGGGTAAAACACACTTCCATTTCTGAATCTTCCCGGCAGTCCTTGCCAAGCTTGAAGGATTCC TGTCAGCGGGAATTGACAAATCTTCTTGGCCTTCACCCCAAAATTGAAATGGCTCGTGCAAGCTGCTCGG CCCTGATGTCTCAGCCTTCTGCCCCAGATTTTGTCCAGCGGGGCTTCGATAGCTTTCTGGGCCGCTACCA AGCTGTACAAGAGGCTGTAGAGGATCGTCAACAACATCTAGAGAATGAACTGAAGGGCCAACCTGGACAT GCATATCTGGAAACATTGAAAACACTGAAAGATGTGCTAAATGATTCAGAAAATAAGGCCCAGGTGTCTC TGAATGTCCTTAATGATCTTGCCAAGGTGGAGAAGGCCCTGCAAGAAAAAAAGACCCTTGATGAAATCCT TGAGAATCAGAAACCTGCATTACATAAACTTGCAGAAGAAACAAAGGCTCTGGAGAAAAATGTTCATCCT GATGTAGAAAAATTATATAAGCAAGAATTTGATGATGTGCAAGGAAAGTGGAACAAGCTAAAGGTCTTGG TTTCCAAAGATCTACATTTGCTTGAGGAAATTGCTCTCACACTCAGAGCTTTTGAGGCCGATTCAACAGT CATTGAGAAGTGGATGGATGGCGTGAAAGACTTCTTAATGAAACAGCAGGCTGCCCAAGGAGACGACGCA GGTCTACAGAGGCAGTTAGACCAGTGCTCTGCATTTGTTAATGAAATAGAAACAATTGAATCATCTCTGA AAAACATGAAGGAAATAGAGACTAATCTTCGAAGTGGTCCAGTTGCTGGAATAAAAACTTGGGTGCAGAC AAGACTAGGTGACTACCAAACTCAACTGGAGAAACTTAGCAAGGAGATCGCTACTCAAAAAAGTAGGTTG TCTGAAAGTCAAGAAAAAGCTGCGAACCTGAAGAAAGACTTGGCAGAGATGCAGGAATGGATGACCCAGG CCGAGGAAGAATATTTGGAGCGGGATTTTGAGTACAAGTCACCAGAAGAGCTTGAGAGTGCTGTGGAAGA GATGAAGAGGGCAAAAGAGGATGTGTTGCAGAAGGAGGTGAGAGTGAAGATTCTCAAGGACAACATCAAG TTATTAGCTGCCAAGGTGCCCTCTGGTGGCCAGGAGTTGACGTCTGAGCTGAATGTTGTGCTGGAGAATT ACCAACTTCTTTGTAATAGAATTCGAGGAAAGTGCCACACGCTAGAGGAGGTCTGGTCTTGTTGGATTGA ACTGCTTCACTATTTGGATCTTGAAACTACCTGGTTAAACACTTTGGAAGAGCGGATGAAGAGCACAGAG GTCCTGCCTGAGAAGACGGATGCTGTCAACGAAGCCCTGGAGTCTCTGGAATCTGTTCTGCGCCACCCGG CAGATAATCGCACCCAGATTCGAGAGCTTGGCCAGACTCTGATTGATGGGGGGATCCTGGATGATATAAT CAGTGAGAAACTGGAGGCTTTCAACAGCCGATATGAAGATCTAAGTCACCTGGCAGAGAGCAAGCAGATT TCTTTGGAAAAGCAACTCCAGGTGCTGCGGGAAACTGACCAGATGCTTCAAGTCTTGCAAGAGAGCTTGG GGGAGCTGGACAAACAGCTCACCACATACCTGACTGACAGGATAGATGCTTTCCAAGTTCCACAGGAAGC TCAGAAAATCCAAGCAGAGATCTCAGCCCATGAGCTAACCCTAGAGGAGTTGAGAAGAAATATGCGTTCT CAGCCCCTGACCTCCCCAGAGAGTAGGACTGCCAGAGGAGGAAGTCAGATGGATGTGCTACAGAGGAAAC TCCGAGAGGTGTCCACAAAGTTCCAGCTTTTCCAGAAGCCAGCTAACTTCGAGCAGCGCATGCTGGACTG CAAGCGTGTGCTGGATGGCGTGAAAGCAGAACTTCACGTTCTGGATGTGAAGGACGTAGACCCTGACGTC ATACAGACGCACCTGGACAAGTGTATGAAACTGTATAAAACTTTGAGTGAAGTCAAACTTGAAGTGGAAA CTGTGATTAAAACAGGAAGACATATTGTCCAGAAACAGCAAACGGACAACCCAAAAGGGATGGATGAGCA GCTGACTTCCCTGAAGGTTCTTTACAATGACCTGGGCGCACAGGTGACAGAAGGAAAACAGGATCTGGAA AGAGCATCACAGTTGGCCCGGAAAATGAAGAAAGAGGCTGCTTCTCTCTCTGAATGGCTTTCTGCTACTG AAACTGAATTGGTACAGAAGTCCACTTCAGAAGGTCTGCTTGGTGACTTGGATACAGAAATTTCCTGGGC TAAAAATGTTCTGAAGGATCTGGAAAAGAGAAAAGCTGATTTAAATACCATCACAGAGAGTAGTGCTGCC CTGCAAAACTTGATTGAGGGCAGTGAGCCTATTTTAGAAGAGAGGCTCTGCGTCCTTAACGCTGGGTGGA GCCGAGTTCGTACCTGGACTGAAGATTGGTGCAATACCTTGATGAACCATCAGAACCAGCTAGAAATATT TGATGGGAACGTGGCTCACATAAGTACCTGGCTTTATCAAGCTGAAGCTCTATTGGATGAAATTGAAAAG AAACCAACAAGTAAACAGGAAGAAATTGTGAAGCGTTTAGTATCTGAGCTGGATGATGCCAACCTCCAGG TTGAAAATGTCCGCGATCAAGCCCTTATTTTGATGAATGCCCGTGGAAGCTCAAGCAGGGAGCTTGTAGA ACCAAAGTTAGCTGAGCTGAATAGGAACTTTGAAAAGGTGTCTCAACATATCAAAAGTGCCAAATTGCTA ATTGCTCAGGAACCATTATACCAATGTTTGGTCACCACTGAAACATTTGAAACTGGTGTGCCTTTCTCTG ACTTGGAAAAATTAGAAAATGACATAGAAAATATGTTAAAATTTGTGGAAAAACACTTGGAATCCAGTGA TGAAGATGAAAAGATGGATGAGGAGAGTGCCCAGATTGAGGAAGTTCTACAAAGAGGAGAAGAAATGTTA CATCAACCTATGGAAGATAATAAAAAAGAAAAGATCCGTTTGCAATTATTACTTTTGCATACTAGATACA ACAAAATTAAGGCAATCCCTATTCAACAGAGGAAAATGGGTCAACTTGCTTCTGGAATTAGATCATCACT TCTTCCTACAGATTATCTGGTTGAAATTAACAAAATTTTACTTTGCATGGATGATGTTGAATTATCGCTT AATGTTCCAGAGCTCAACACTGCTATTTACGAAGACTTCTCTTTTCAGGAAGACTCTCTGAAGAATATCA AAGACCAACTGGACAAACTTGGAGAGCAGATTGCAGTCATTCATGAAAAACAGCCAGATGTCATCCTTGA AGCCTCTGGACCTGAAGCCATTCAGATCAGAGATACACTTACTCAGCTGAATGCAAAATGGGACAGAATT AATAGAATGTACAGTGATCGGAAAGGTTGTTTTGACAGGGCAATGGAAGAATGGAGACAGTTCCATTGTG ACCTTAATGACCTCACACAGTGGATAACAGAGGCTGAAGAATTACTGGTTGATACCTGTGCTCCAGGTGG CAGCCTGGACTTAGAGAAAGCCAGGATACATCAGCAGGAACTTGAGGTGGGCATCAGCAGCCACCAGCCC AGTTTTGCAGCACTAAACCGAACTGGGGATGGGATTGTGCAGAAACTCTCCCAGGCAGATGGAAGCTTCT TGAAAGAAAAACTGGCAGGTTTAAACCAACGCTGGGATGCAATTGTTGCAGAAGTGAAGGATAGGCAGCC AAGGCTAAAAGGAGAAAGTAAGCAGGTGATGAAGTACAGGCATCAGCTAGATGAGATTATCTGTTGGTTA ACAAAGGCTGAGCATGCTATGCAAAAGAGATCAACCACCGAATTGGGAGAAAACCTGCAAGAATTAAGAG ACTTAACTCAAGAAATGGAAGTACATGCTGAAAAACTCAAATGGCTGAATAGAACTGAATTGGAGATGCT TTCAGATAAAAGTCTGAGTTTACCTGAAAGGGATAAAATTTCAGAAAGCTTAAGGACTGTAAATATGACA TGGAATAAGATTTGCAGAGAGGTGCCTACCACCCTGAAGGAATGCATCCAGGAGCCCAGTTCTGTTTCAC AGACAAGGATTGCTGCTCATCCTAATGTCCAAAAGGTGGTGCTAGTATCATCTGCGTCAGATATTCCTGT TCAGTCTCATCGTACTTCGGAAATTTCAATTCCTGCTGATCTTGATAAAACTATAACAGAACTAGCCGAC TGGCTGGTATTAATCGACCAGATGCTGAAGTCCAACATTGTCACTGTTGGGGATGTAGAAGAGATCAATA AGACCGTTTCCCGAATGAAAATTACAAAGGCTGACTTAGAACAGCGCCATCCTCAGCTGGATTATGTTTT TACATTGGCACAGAATTTGAAAAATAAAGCTTCCAGTTCAGATATGAGAACAGCAATTACAGAAAAATTG GAAAGGGTCAAGAACCAGTGGGATGGCACCCAGCATGGCGTTGAGCTAAGACAGCAGCAGCTTGAGGACA TGATTATTGACAGTCTTCAGTGGGATGACCATAGGGAGGAGACTGAAGAACTGATGAGAAAATATGAGGC TCGACTCTATATTCTTCAGCAAGCCCGACGGGATCCACTCACCAAACAAATTTCTGATAACCAAATACTG CTTCAAGAACTGGGTCCTGGAGATGGTATCGTCATGGCGTTCGATAACGTCCTGCAGAAACTCCTGGAGG AATATGGGAGTGATGACACAAGGAATGTGAAAGAAACCACAGAGTACTTAAAAACATCATGGATCAATCT CAAACAAAGTATTGCTGACAGACAGAACGCCTTGGAGGCTGAGTGGAGGACGGTGCAGGCCTCTCGCAGA GATCTGGAAAACTTCCTGAAGTGGATCCAAGAAGCAGAGACCACAGTGAATGTGCTTGTGGATGCCTCTC ATCGGGAGAATGCTCTTCAGGATAGTATCTTGGCCAGGGAACTCAAACAGCAGATGCAGGACATCCAGGC AGAAATTGATGCCCACAATGACATATTTAAAAGCATTGACGGAAACAGGCAGAAGATGGTAAAAGCTTTG GGAAATTCTGAAGAGGCTACTATGCTTCAACATCGACTGGATGATATGAACCAAAGATGGAATGACTTAA AAGCAAAATCTGCTAGCATCAGGGCCCATTTGGAGGCCAGCGCTGAGAAGTGGAACAGGTTGCTGATGTC CTTAGAAGAACTGATCAAATGGCTGAATATGAAAGATGAAGAGCTTAAGAAACAAATGCCTATTGGAGGA GATGTTCCAGCCTTACAGCTCCAGTATGACCATTGTAAGGCCCTGAGACGGGAGTTAAAGGAGAAAGAAT ATTCTGTCCTGAATGCTGTCGACCAGGCCCGAGTTTTCTTGGCTGATCAGCCAATTGAGGCCCCTGAAGA GCCAAGAAGAAACCTACAATCAAAAACAGAATTAACTCCTGAGGAGAGAGCCCAAAAGATTGCCAAAGCC ATGCGCAAACAGTCTTCTGAAGTCAAAGAAAAATGGGAAAGTCTAAATGCTGTAACTAGCAATTGGCAAA AGCAAGTGGACAAGGCATTGGAGAAACTCAGAGACCTGCAGGGAGCTATGGATGACCTGGACGCTGACAT GAAGGAGGCAGAGTCCGTGCGGAATGGCTGGAAGCCCGTGGGAGACTTACTCATTGACTCGCTGCAGGAT CACATTGAAAAAATCATGGCATTTAGAGAAGAAATTGCACCAATCAACTTTAAAGTTAAAACGGTGAATG ATTTATCCAGTCAGCTGTCTCCACTTGACCTGCATCCCTCTCTAAAGATGTCTCGCCAGCTAGATGACCT TAATATGCGATGGAAACTTTTACAGGTTTCTGTGGATGATCGCCTTAAACAGCTTCAGGAAGCCCACAGA GATTTTGGACCATCCTCTCAGCATTTTCTCTCTACGTCAGTCCAGCTGCCGTGGCAAAGATCCATTTCAC ATAATAAAGTGCCCTATTACATCAACCATCAAACACAGACCACCTGTTGGGACCATCCTAAAATGACCGA ACTCTTTCAATCCCTTGCTGACCTGAATAATGTACGTTTTTCTGCCTACCGTACAGCAATCAAAATCCGA AGACTACAAAAAGCACTATGTTTGGATCTCTTAGAGTTGAGTACAACAAATGAAATTTTCAAACAGCACA AGTTGAACCAAAATGACCAGCTCCTCAGTGTTCCAGATGTCATCAACTGTCTGACAACAACTTATGATGG ACTTGAGCAAATGCATAAGGACCTGGTCAACGTTCCACTCTGTGTTGATATGTGTCTCAATTGGTTGCTC AATGTCTATGACACGGGTCGAACTGGAAAAATTAGAGTGCAGAGTCTGAAGATTGGATTAATGTCTCTCT CCAAAGGTCTCTTGGAAGAAAAATACAGATATCTCTTTAAGGAAGTTGCAGGGCCAACAGAAATGTGTGA CCAGAGGCAGCTGGGCCTGTTACTTCATGATGCCATCCAGATCCCCCGGCAGCTAGGTGAAGTAGCAGCT TTTGGAGGCAGTAATATTGAGCCTAGTGTTCGCAGCTGCTTCCAACAGAATAACAATAAACCAGAAATAA GTGTGAAAGAGTTTATAGATTGGATGCATTTGGAACCACAGTCCATGGTTTGGCTCCCAGTTTTACATCG AGTGGCAGCAGCGGAGACTGCAAAACATCAGGCCAAATGCAACATCTGTAAAGAATGTCCAATTGTCGGG TTCAGGTATAGAAGCCTTAAGCATTTTAACTATGATGTCTGCCAGAGTTGTTTCTTTTCGGGTCGAACAG CAAAAGGTCACAAATTACATTACCCAATGGTGGAATATTGTATACCTACAACATCTGGGGAAGATGTACG AGACTTCACAAAGGTACTTAAGAACAAGTTCAGGTCGAAGAAGTACTTTGCCAAACACCCTCGACTTGGT TACCTGCCTGTCCAGACAGTTCTTGAAGGTGACAACTTAGAGACTCCTATCACACTCATCAGTATGTGGC CAGAGCACTATGACCCCTCACAATCTCCTCAACTGTTTCATGATGACACCCATTCAAGAATAGAACAATA TGCCACACGACTGGCCCAGATGGAAAGGACTAATGGGTCTTTTCTCACTGATAGCAGCTCCACCACAGGA AGTGTGGAAGACGAGCACGCCCTCATCCAGCAGTATTGCCAAACACTCGGAGGAGAGTCCCCAGTGAGCC AGCCGCAGAGCCCAGCTCAGATCCTGAAGTCAGTAGAGAGGGAAGAACGTGGAGAACTGGAGAGGATCAT TGCTGACCTGGAGGAAGAACAAAGAAATCTACAGGTGGAGTATGAGCAGCTGAAGGACCAGCACCTCCGA AGGGGGCTCCCTGTCGGTTCACCGCCAGAGTCGATTATATCTCCCCATCACACGTCTGAGGATTCAGAAC TTATAGCAGAAGCAAAACTCCTCAGGCAGCACAAAGGTCGGCTGGAGGCTAGGATGCAGATTTTAGAAGA TCACAATAAACAGCTGGAGTCTCAGCTCCACCGCCTCCGACAGCTGCTGGAGCAGCCTGAATCTGATTCC CGAATCAATGGTGTTTCCCCATGGGCTTCTCCTCAGCATTCTGCACTGAGCTACTCGCTTGATCCAGATG CCTCCGGCCCACAGTTCCACCAGGCAGCGGGAGAGGACCTGCTGGCCCCACCGCACGACACCAGCACGGA TCTCACGGAGGTCATGGAGCAGATTCACAGCACGTTTCCATCTTGCTGCCCAAATGTTCCCAGCAGGCCA CAGGCAATGTGA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_007124 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones. |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_007124.2, NP_009055.2 |
| RefSeq Size | 12436 bp |
| RefSeq ORF | 10302 bp |
| Locus ID | 7402 |
| Cytogenetics | 6q24.2 |
| Domains | ZnF_ZZ, WW, CH, spectrin |
| Protein Families | Druggable Genome |
| Gene Summary | 'This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]' |
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