MTMR3 (NM_153050) Human Untagged Clone

CAT#: SC309961

MTMR3 (untagged)-Human myotubularin related protein 3 (MTMR3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MTMR3
• Synonyms: FYVE-DSP1; ZFYVE10
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_153050, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGATGAAGAGACTCGGCACAGCCTTGAGTGCATCCAGGCCAATCAGATCTTTCCCAGGAAGCAGCTGA
  TCCGGGAGGATGAGAATCTTCAGGTTCCTTTCCTTGAACTTCATGGAGAGAGCACAGAGTTTGTGGGCCG
  TGCCGAGGATGCCATCATTGCCCTTTCCAATTACAGACTTCACATCAAGTTCAAGGAGTCTCTTGTTAAT
  GTTCCATTACAGCTTATAGAAAGTGTTGAATGCCGAGATATATTTCAGCTTCATTTGACTTGCAAAGACT
  GCAAAGTTATCAGGTGTCAGTTTTCAACCTTTGAGCAGTGTCAAGAGTGGCTGAAGAGACTGAACAACGC
  AATCCGACCACCTGCTAAAATAGAAGATCTCTTCTCATTTGCATACCATGCTTGGTGCATGGAGGTCTAT
  GCCAGTGAAAAAGAGCAACATGGAGACCTGTGCAGACCAGGGGAGCATGTAACTTCAAGGTTTAAAAACG
  AGGTGGAGAGGATGGGTTTTGATATGAACAACGCCTGGAGGATTTCCAACATCAATGAGAAGTACAAATT
  ATGTGGTAGCTATCCTCAAGAGCTCATAGTGCCTGCCTGGATCACTGACAAAGAACTGGAAAGTGTATCA
  AGTTTCAGGTCCTGGAAGCGCATCCCTGCCGTCATCTACAGGCACCAGAGCAATGGAGCTGTCATTGCCC
  GCTGTGGACAGCCAGAGGTTAGCTGGTGGGGCTGGCGAAATGCAGATGATGAGCATCTGGTACAGTCAGT
  AGCCAAAGCTTGTGCCTCTGACTCCCGATCGAGTGGCAGCAAGCTGTCAACTAGGAACACTTCTCGAGAC
  TTTCCCAATGGGGGAGACCTTTCTGACGTGGAGTTCGATTCTTCTCTGTCAAATGCTTCAGGAGCAGAGA
  GTTTAGCCATCCAACCGCAGAAGCTTTTGATCTTGGATGCACGCTCCTATGCAGCTGCTGTGGCAAACCG
  AGCCAAAGGAGGAGGCTGCGAATGCCCAGAGTATTACCCAAACTGTGAAGTTGTGTTTATGGGGATGGCA
  AACATTCATTCTATTCGGAGGAGTTTTCAGTCTCTGCGGTTGCTGTGCACTCAGATGCCAGATCCGGGAA
  ATTGGCTATCAGCTCTTGAAAGCACAAAATGGCTCCATCACTTGTCTGTGCTTCTGAAATCAGCGCTTCT
  GGTAGTGCATGCTGTGGATCAGGATCAGCGGCCGGTGCTAGTACACTGCTCAGATGGCTGGGACCGCACC
  CCCCAGATTGTGGCATTGGCTAAGCTCTTGCTGGACCCTTATTACCGAACCATAGAGGGTTTCCAGGTCC
  TCGTGGAAATGGAGTGGCTGGATTTTGGCCATAAATTTGCTGACCGGTGTGGTCATGGGGAGAACTCGGA
  TGATCTGAATGAACGTTGCCCAGTGTTTCTGCAGTGGCTTGACTGTGTTCATCAGCTTCAGAGGCAATTT
  CCTTGCTCTTTTGAGTTCAATGAAGCATTCCTTGTGAAACTGGTGCAGCATACCTATTCCTGCCTGTTTG
  GAACATTCCTGTGCAACAACGCCAAGGAGAGAGGGGAAAAGCATACTCAGGAACGGACATGTTCCGTGTG
  GTCACTTCTTCGGGCAGGCAACAAGGCTTTCAAAAACCTACTGTATTCCTCTCAGTCAGAAGCCGTGCTG
  TACCCTGTGTGCCATGTGCGTAACCTGATGCTGTGGAGTGCAGTGTACCTGCCCTGCCCATCCCCAACCA
  CCCCTGTGGACGACAGCTGTGCACCATACCCAGCCCCAGGCACCAGCCCTGATGATCCCCCCCTGAGCCG
  GCTACCAAAGACTAGATCATACGACAATCTGACCACAGCCTGTGACAACACAGTGCCTCTGGCCAGCCGG
  CGCTGCAGCGACCCCAGCCTGAACGAGAAGTGGCAGGAGCACCGGCGCTCACTAGAGCTGAGCAGCCTGG
  CTGGCCCTGGAGAGGATCCCCTTTCTGCCGACAGCCTAGGGAAGCCCACCAGAGTGCCGGGGGGTGCCGA
  GCTTTCTGTTGCAGCCGGAGTAGCTGAGGGGCAGATGGAGAACATCTTGCAGGAGGCCACCAAAGAGGAG
  AGTGGAGTAGAGGAACCTGCCCACAGGGCAGGCATTGAGATACAGGAGGGTAAAGAGGACCCTCTCTTAG
  AAAAGGAGAGCAGGAGGAAGACACCTGAGGCCTCAGCCATTGGACTTCACCAAGACCCAGAACTGGGTGA
  TGCTGCTCTGAGGAGCCATCTGGATATGAGCTGGCCTCTGTTCTCACAGGGCATTTCTGAACAGCAGAGT
  GGGCTCAGTGTTCTCCTCAGTTCTCTCCAGGTCCCCCCCAGGGGAGAGGATTCCCTGGAGGTCCCTGTGG
  AGCAGTTTCGAATAGAAGAGATTGCAGAGGGTAGGGAGGAAGCAGTTCTTCCAATCCCAGTAGATGCAAA
  AGTTGGCTATGGTACCTCACAGTCATGTTCTCTGCTACCTTCCCAAGTCCCTTTTGAGACCAGAGGACCA
  AACGTGGACAGTTCTACAGACATGTTAGTGGAAGATAAGGTGAAGTCAGTAAGTGGGCCCCAAGGTCATC
  ATAGATCTTGCCTTGTAAATAGTGGCAAGGACAGGCTTCCTCAGACCATGGAACCCAGCCCTTCAGAGAC
  AAGCCTGGTCGAGAGGCCCCAAGTGGGGTCTGTGGTGCATAGGACTTCCCTTGGCAGCACTCTCAGCCTG
  ACACGTTCCCCTTGTGCCTTGCCTTTAGCCGAATGTAAAGAGGGGCTTGTGTGCAATGGTGCCCCAGAGA
  CTGAAAACAGGGCCTCAGAGCAGCCCCCAGGTCTTAGCACCCTCCAGATGTACCCCACACCCAATGGGCA
  TTGCGCCAATGGGGAGGCTGGTAGGAGCAAGGACTCACTGAGCCGTCAGCTGTCTGCTATGAGCTGCAGC
  TCTGCCCACTTACACTCAAGGAACTTGCACCACAAGTGGCTGCATAGCCACTCAGGAAGGCCATCTGCAA
  CCAGCAGCCCCGACCAGCCTTCCCGCAGCCACCTGGACGATGATGGCATGTCAGTGTACACAGACACGAT
  CCAACAGCGCCTGCGTCAGATTGAGTCAGGCCACCAGCAGGAAGTAGAAACTTTGAAGAAACAAGTCCAG
  GAGCTGAAGAGTCGCCTGGAGAGCCAGTACCTGACCAGCTCCCTACACTTTAATGGAGACTTTGGGGATG
  AGGTGATGACCCGTTGGCTTCCTGACCACCTGGCCGCCCACTGCTATGCGTGCGACAGTGCCTTCTGGCT
  TGCCAGCAGGAAGCACCACTGCAGGGACACTGACCGTGTTGATCAAACGTGGAATTGTGGGAACGTATTC
  TGCTCCAGTTGTTGTAACCAGAAGGTTCCAGTTCCCAGCCAGCAGCTCTTTGAACCCAGTCGAGTATGCA
  AGTCTTGCTATAGCAGCCTACATCCCACAAGCTCCAGCATTGACCTTGAACTGGATAAGCCCATTGCTGC
  CACTTCCAACTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_153050
• ORF Size: 3513 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_153050.2, NP_694690.1
• RefSeq Size: 8924
• RefSeq ORF: 3513
• Locus ID: 8897
• Protein Families: Druggable Genome, Phosphatase
• Gene Summary: This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) includes an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 3, resulting in a protein (isoform a) that is shorter than isoform c. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.