CCNL2 (NM_001039577) Human Untagged Clone

CAT#: SC310780

CCNL2 (untagged)-Human cyclin L2 (CCNL2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CCNL2
• Synonyms: ANIA-6B; CCNM; CCNS; HCLA-ISO; HLA-ISO; PCEE; SB138
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001039577, the custom clone sequence may differ by one or more nucleotides
  ATGGCGGCGGCGGCGGCGGCGGCTGGTGCTGCAGGGTCGGCAGCTCCCGCGGCAGCGGCC
  GGCGCCCCGGGATCTGGGGGCGCACCCTCAGGGTCGCAGGGGGTGCTGATCGGGGACAGG
  CTGTACTCCGGGGTGCTCATCACCTTGGAGAACTGCCTCCTGCCTGACGACAAGCTCCGT
  TTCACGCCGTCCATGTCGAGCGGCCTCGACACCGACACAGAGACCGACCTCCGCGTGGTG
  GGCTGCGAGCTCATCCAGGCGGCCGGTATCCTGCTCCGCCTGCCGCAGGTGGCCATGGCT
  ACCGGGCAGGTGTTGTTCCAGCGGTTCTTTTATACCAAGTCCTTCGTGAAGCACTCCATG
  GAGCATGTGTCAATGGCCTGTGTCCACCTGGCTTCCAAGATAGAAGAGGCCCCAAGACGC
  ATACGGGACGTCATCAATGTGTTTCACCGCCTTCGACAGCTGAGAGACAAAAAGAAGCCC
  GTGCCTCTACTACTGGATCAAGATTATGTTAATTTAAAGAACCAAATTATAAAGGCGGAA
  AGACGAGTTCTCAAAGAGTTGGGTTTCTGCGTCCATGTGAAGCATCCTCATAAGATAATC
  GTTATGTACCTTCAGGTGTTAGAGTGTGAGCGTAACCAACACCTGGTCCAGACCTCATGG
  GTAGCCTCTGAGGGTAAGTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_001039577
• ORF Size: 681 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001039577.1, NP_001034666.1
• RefSeq Size: 5260
• RefSeq ORF: 681
• Locus ID: 81669
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  Transcript Variant: This variant (2, also known as L2betaA3 or T3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (B), also known as L2betaA, contains the cyclin box in the N-terminus and lacks the arginine/serine-rich domain (RS domain) in the C-terminus, compared to isoform A. CCDS Note: This CCDS represents the L2betaA isoform of the cyclin L2 locus, as described in PMID:18216018. The transcript is supported by BC016333.1, which is processed at an internal polyA site compared to other transcripts at this locus. The mRNA AK074112.1 also contains the same CDS. However, because the latter mRNA has additional 3' exon structure and the stop codon is present in an internal exon, that transcript is expected to be subject to nonsense-mediated mRNA decay (NMD), whereas transcripts processed at the internal polyA site are predicted to be translated.