ABCG8 (NM_022437) Human Untagged Clone

CAT#: SC311404

ABCG8 (untagged)-Human ATP-binding cassette, sub-family G (WHITE), member 8 (ABCG8)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ABCG8
• Synonyms: GBD4; STSL
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_022437 edited
  ATGGCCGGGAAGGCGGCAGAGGAGAGAGGGCTGCCGAAAGGGGCCACTCCCCAGGATACC
  TCGGGCCTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTAC
  AGTGGCCAGCCCAACACCCTGGAGGTCAGAGACCTCAACTGCCAGGTGGACCTGGCCTCT
  CAGGTCCCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGACATCTCCCAGCTGC
  CAGAATTCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATG
  CTGGCCATCATAGGGAGCTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGC
  CGAGGTCACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGGGCAGCCCAGCTCG
  CCTCAGCTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAAC
  TTGACTGTGCGAGAGACCTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCC
  CAGGCCCAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCGGCTTAGGCAGTGC
  GCTGACACCCGCGTGGGCAACATGTACGTGCGGGGGTTGTCGGGGGGTGAGCGCAGGAGA
  GTCAGCATTGGGGTGCAGCTCCTGTGGAACCCAGGAATCCTTATTCTCGACGAACCCACC
  TCTGGGCTCGACAGCTTCACAGCCCACAACCTGGTGAAGACCTTGTCCAGGCTGGCCAAA
  GGCAACCGGCTGGTGCTCATCTCCCTCCACCAGCCTCGCTCTGACATCTTCAGGCTGTTT
  GATCTGGTCCTCCTGATGACGTCTGGCACCCCCATCTACTTAGGGGCGGCCCAGCACATG
  GTCCAGTATTTCACAGCCATCGGCTACCCCTGTCCTCGCTACAGCAATCCTGCTGACTTC
  TATGTGGACCTGACCAGCATTGACAGGCGCAGCAGAGAGCAGGAATTGGCCACCAGGGAG
  AAGGCTCAGTCACTCGCAGCCCTGTTTCTAGAAAAAGTGCGTGACTTAGATGACTTTCTA
  TGGAAAGCAGAGACGAAGGATCTTGACGAGGACACCTGTGTGGAAAGCAGCGTGACCCCA
  CTAGACACCAACTGCCTCCCGAGTCCTACGAAGATGCCTGGGGCGGTGCAGCAGTTTACG
  ACGCTGATCCGTCGTCAGATTTCCAACGACTTCCGAGACCTGCCCACCCTCCTCATCCAT
  GGGGCGGAGGCCTGTCTGATGTCAATGACCATCGGCTTCCTCTATTTTGGCCATGGGAGC
  ATCCAGCTCTCCTTCATGGATACAGCCGCCCTCTTGTTCATGATCGGTGCTCTCATCCCT
  TTCAACGTCATTCTGGATGTCATCTCCAAATGTTACTCAGAGAGGGCAATGCTTTACTAT
  GAACTGGAAGACGGGCTGTACACCACTGGTCCATATTTCTTTGCCAAGATCCTCGGGGAG
  CTTCCGGAGCACTGTGCCTACATCATCATCTACGGGATGCCCACCTACTGGCTGGCCAAC
  CTGAGGCCAGGCCTCCAGCCCTTCCTGCTGCACTTCCTGCTGGTGTGGCTGGTGGTCTTC
  TGTTGCAGGATTATGGCCCTGGCCGCCGCGGCCCTGCTCCCCACCTTCCACATGGCCTCC
  TTCTTCAGCAATGCCCTCTACAACTCCTTCTACCTCGCCGGGGGCTTCATGATAAACTTG
  AGCAGCCTGTGGACAGTGCCCGCGTGGATTTCCAAAGTGTCCTTCCTGCGGTGGTGTTTT
  GAAGGGCTGATGAAGATTCAGTTCAGCAGAAGAACTTATAAAATGCCTCTCGGGAACCTC
  ACCATCGCGGTCTCAGGAGATAAAATCCTCAGTGCCATGGAGCTGGACTCGTACCCTCTC
  TACGCCATCTACCTCATCGTCATTGGCCTCAGCGGTGGCTTCATGGTCCTGTACTACGTG
  TCCTTAAGGTTCATCAAACAGAAACCAAGTCAAGACTGGTGATTCACGCCAGACGTCTGC
  CCGCTGGTGGGGGACCTGAGCAGACCCTTCAACTGCACTCCCTCCTCAGGAGCCCCTTCC
  TGGGGACAGTGAGGACAATGACCCTACAGATGCTCAGCTACATCCGGCCCAGGGTGCTGC
  AGTGGCACAGACCAGCCACAGGATGGCAGTAGAATAAAGACAGTCGAAAGGGATTTCTGC
  TCACTGGCAGGAGACTGCGATGACTGGGAGAAAACCTGCACTCGGTGGCACCTACAACGT
  TGCTAATTTATTTCCTTTTGATAGGCATTTAAATAGGCAACTCGATATAGGATGGGAGCA
  AACTAGGAATGAATTGGGTAGCTAGACTGTGCAGGAATTGTTGGAACCTGGAGGGAACAA
  TAACAGTAGCTAGCAGATTTGGCTTCATCTTCCAGGGGCCCCACACTCCGTGGTGAGCCC
  CCATCAATACAGAAAGTGACCTAAGATGTACCAGCAAGATGCCATCCCTTCTTTTTGTGT
  GGGGTCATGGGCTCCAAAAGCCAACGTGAACAATTAAAAATGTATTGAGCATTTACTCTG
  TAGCAGGTCCTGTGAAAACACTTTAGGTGGACAATCCCTTGAGGTAAAGGGTATCCCATT
  TTATAGGTGTGAAAACTGAAGCAAAAATTCATTTTCTTAAGGGCAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022437 unedited
  NNGGTTTAGTTCAGAATTGTATACCATCATATAGGCGGCCGCGNAATTCGCACGAGGATG
  GCCGGGAAGGCGGCAGAGAGAGAGGCTGCCGAAGGGGCCACTCCCCAGGATACCTCGGGC
  CTCCAGGATAGATTGTTCTCCTCTGAAAGTGACAACAGCCTGTACTTCACCTACAGTGGC
  CAGCCCAACACCCTGGAGGTCAGAGACCTCAACTGCCAGGTGGACCTGGCCTCTCAGGTC
  CCTTGGTTTGAGCAGCTGGCTCAGTTCAAGATGCCCTGGACATCTCCCAGCTGCCAGAAT
  TCTTGTGAGCTGGGCATCCAGAACCTAAGCTTCAAAGTGAGAAGTGGGCAGATGCTGGCC
  ATCATAGGGAGCTCAGGTTGTGGGAGAGCCTCCTTGCTAGATGTGATCACTGGCCGAGGT
  CACGGCGGCAAGATCAAGTCAGGCCAGATCTGGATCAATGGGCAGCCCAGCTCGCCTCAG
  CTGGTGAGGAAGTGTGTGGCCCACGTGCGCCAGCACAACCAGCTGCTCCCCAACTTGACT
  GTGCGAGAGACCTTGGCCTTCATTGCCCAGATGCGGCTGCCCAGAACCTTCTCCCAGGCC
  CAGCGTGACAAAAGGGTGGAGGACGTGATCGCGGAGCTGCGGCTTAAGCAGTGCGCTGAC
  ACCCGCGTGGGCAACATGTACGTGCGGNGGTTGTNCGGGGGTGAGCGCANGAGAGTCAGC
  ATTTGGGTGCAGCTTCTGTGNGACCCAGGAATCCTTATTCTCGACGACCCACCTCTGGGC
  TCGACAGCTTCACAGCCCACAACCTGGTGAAAGACCCTGTNCAGNCTGGCCAAAGGCACC
  CGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' genomic read for NM_022437 unedited
  CCTTGGGGTGGCAATTCCCATTCCAGNNGNAGCACTGGGGCGGGGTCACAGGGNTGCCAC
  CCGGGATCTGTTCAGGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCCCTTAGGAAAATGAATTTTTGCTTC
  AGTTTTCACACCTATAAAATGGGATACCATTTTCCTCAAGGGATTGTCCACCTAAAGTGT
  TTTCACAGGACCTGCTACAGAGTAAATGCTCAATACATTTTTAATTGTTCACGTTGGCTT
  TTGGAGCCCATGACCCCACACAAAAAGAAGGGATGGCATCTTGCTGGGACATCTTAAGTC
  ACTTTCTGTATTGGTGGGGGCTCACCACGGAGTGTGGGGCCCCTGGAAGATGAAGCCAAA
  TCTGCTAGCTACTGGTATTGTTCCCTCCAGGTTCCAACAATTCCTGGACAGTCTAGCTAC
  CCAATTCATTCCTAGTTTGCTCCCATCCTATATCGAGTTGCCTATATTAATGCCTATCAA
  AAGGGAATAAATTAGCAACGTTGTAGGTGCCACCGAGTGCAGGTTTTCTCCCAGTCATCG
  CAGTCTCCTGCCAGGGAGCAGAAATCCCTTTGGACTGTCTTTATTTTACTGGCCTCCTGG
  GGCTGGGCTGGGGCCCTTGAGCACCCTGGGCCGGATGTAACTTGACCTTTGGGGGGGCAT
  TGGCCTCACTGTCCCCAAGAAGGGGCTCCTGAAGGAGGGAGTGCAGTTTAAGGGTTTTGC
  TCAGTCCCCCACCAAGGGGGAAAACTTTTTGGCGTGAATTACCAAGGTTTGGT
  
• Restriction Sites: Please inquire
• ACCN: NM_022437
• ORF Size: 2022 bp
• Insert Size: 2800
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_022437.2, NP_071882.1
• RefSeq Size: 2679
• RefSeq ORF: 2022
• Locus ID: 64241
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters
• Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the longer isoform (1).