CD89 (FCAR) (NM_133272) Human Untagged Clone

CAT#: SC312768

FCAR (untagged)-Human Fc fragment of IgA, receptor for (FCAR), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FCAR
• Synonyms: CD89; CTB-61M7.2; FcalphaRI
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_133272, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGACCCCAAACAGACCACCCTCCTGTGTCTTGGGGACTTTCCCATGCCTTTCATATCTGCCAAATCGA
  GTCCTGTGATTCCCTTGGATGGATCTGTGAAAATCCAGTGCCAGGCCATTCGTGAAGCTTACCTGACCCA
  GCTGATGATCATAAAAAACTCCACGTACCGAGAGATAGGCAGAAGACTGAAGTTTTGGAATGAGACTGAT
  CCTGAGTTCGTCATTGACCACATGGACGCAAACAAGGCAGGGCGCTATCAGTGCCAATATAGGATAGGGC
  ACTACAGGTTCCGGTACAGTGACACCCTGGAGCTGGTAGTGACAGGCTTGTATGGCAAACCCTTCCTCTC
  TGCAGATCGGGGTCTGGTGTTGATGCCAGGAGAGAATATTTCCCTCACGTGCAGCTCAGCACACATCCCA
  TTTGATAGATTTTCACTGGCCAAGGAGGGAGAACTTTCTCTGCCACAGCACCAAAGTGGGGAACACCCGG
  CCAACTTCTCTTTGGGTCCTGTGGACCTCAATGTCTCAGGGATCTACAGGTGCTACGGTTGGTACAACAG
  GAGCCCCTACCTGTGGTCCTTCCCCAGTAATGCCTTGGAGCTTGTGGTCACAGACTCCATCCACCAAGAT
  TACACGACGCAGAACTTGATCCGCATGGCCGTGGCAGGACTGGTCCTCGTGGCTCTCTTGGCCATACTGG
  TTGAAAATTGGCACAGCCATACGGCACTGAACAAGGAAGCCTCGGCAGATGTGGCTGAACCGAGCTGGAG
  CCAACAGATGTGTCAGCCAGGATTGACCTTTGCACGAACACCAAGTGTCTGCAAGTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_133272
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_133272.3, NP_579806.1
• RefSeq Size: 2582 bp
• RefSeq ORF: 828 bp
• Locus ID: 2204
• Cytogenetics: 19q13.42
• Domains: ig
• Protein Families: Transmembrane
• Gene Summary: 'This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.