POLE2 (NM_002692) Human Untagged Clone

CAT#: SC313869

POLE2 (untagged)-Human polymerase (DNA directed), epsilon 2 (p59 subunit) (POLE2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: POLE2
• Synonyms: DPE2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_002692, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGCCGGAGCGGCTGCGGAGCCGGGCGCTCTCCGCCTTCAAGTTGCGGGGCTTGCTGCTCCGTGGTG
  AAGCTATTAAGTACCTCACAGAAGCTCTTCAGTCTATCAGTGAATTAGAGCTTGAAGATAAACTGGAAAA
  GATAATTAATGCAGTTGAGAAGCAACCCTTGTCATCAAACATGATTGAACGATCTGTGGTGGAAGCAGCA
  GTCCAGGAATGCAGTCAGTCTGTTGATGAAACTATAGAGCACGTTTTCAATATCATAGGAGCATTTGATA
  TTCCACGCTTTGTGTACAATTCAGAAAGAAAAAAATTTCTTCCTCTGTTAATGACCAACCACCCTGCACC
  AAATTTATTTGGAACACCAAGAGATAAAGCAGAGATGTTTCGTGAGCGATATACCATTTTGCACCAGAGG
  ACCCACAGGCATGAATTATTTACTCCTCCGGTGATAGGTTCTCACCCTGATGAAAGCGGAAGCAAATTCC
  AGCTTAAAACAATAGAAACCTTATTGGGTAGTACAACCAAAATCGGAGATGCGATTGTTCTTGGAATGAT
  AACGCAGTTAAAAGAGGGAAAATTTTTTCTGGAAGATCCTACTGGAACAGTCCAACTAGACCTTAGTAAA
  GCTCAGTTCCATAGTGGTTTATACACAGAGGCATGCTTTGTCTTAGCAGAAGGTTGGTTTGAAGATCAAG
  TGTTTCATGTCAATGCCTTTGGATTTCCACCCACTGAGCCCTCTAGTACTACTAGGGCATACTATGGAAA
  TATTAATTTTTTTGGAGGTCCTTCTAATACATCTGTGAAGACTTCTGCAAAACTAAAACAGCTAGAAGAG
  GAGAATAAAGATGCTATGTTTGTGTTTTTATCTGATGTTTGGTTGGACCAGGTGGAAGTATTGGAAAAAC
  TTCGCATAATGTTTGCTGGTTATTCACCAGCACCTCCAACCTGCTTTATTCTGTGTGGTAATTTTTCATC
  TGCACCATATGGAAAAAATCAAGTTCAAGCTTTGAAAGATTCCCTAAAAACTTTGGCAGATATAATATGT
  GAATACCCAGATATTCACCAAAGTAGTCGTTTTGTGTTTGTACCTGGTCCAGAGGATCCTGGATTTGGTT
  CCATCTTACCAAGGCCACCACTTGCTGAAAGCATCACTAATGAATTCAGACAAAGGGTACCATTTTCAGT
  TTTTACTACTAATCCTTGCAGAATTCAGTACTGTACACAGGAAATTACTGTCTTCCGTGAAGACTTAGTA
  AATAAAATGTGCAGAAACTGCGTCCGTTTTCCTAGCAGCAATTTGGCTATTCCTAATCACTTTGTAAAGA
  CTATCTTATCCCAAGGACATCTGACTCCCCTACCTCTTTATGTCTGCCCAGTGTATTGGGCATATGACTA
  TGCTTTGAGAGTGTATCCTGTGCCCGATCTACTTGTCATTGCAGACAAATATGATCCTTTCACTACGACA
  AATACCGAATGCCTCTGCATAAACCCTGGCTCTTTTCCAAGAAGTGGATTTTCATTCAAAGTTTTTTATC
  CTTCTAATAAGACAGTAGAAGATAGCAAACTTCAAGGCTTTTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_002692
• ORF Size: 1584 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_002692.3, NP_002683.2
• RefSeq Size: 1861
• RefSeq ORF: 1584
• Locus ID: 5427
• Domains: DNA_pol_E_B
• Protein Pathways: Base excision repair, DNA replication, Metabolic pathways, Nucleotide excision repair, Purine metabolism, Pyrimidine metabolism
• Gene Summary: DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency. [provided by RefSeq, Jan 2017]
  Transcript Variant: This variant (1) encodes the longest isoform (1).