ADAM22 (NM_004194) Human Untagged Clone

CAT#: SC314828

ADAM22 (untagged)-Human ADAM metallopeptidase domain 22 (ADAM22), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAM22
• Synonyms: ADAM 22; EIEE61; MDC2
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_004194, the custom clone sequence may differ by one or more nucleotides
  ATGCAGGCGGCAGTGGCTGTGTCCGTGCCCTTCTTGCTGCTCTGTGTCCTGGGGACCTGC
  CCTCCGGCGCGCTGCGGCCAGGCAGGAGACGCCTCATTGATGGAGCTAGAGAAGAGGAAG
  GAAAACCGCTTCGTGGAGCGCCAGAGCATCGTGCCACTGCGCCTCATCTACCGCTCGGGC
  GGCGAAGACGAAAGTCGGCACGACGCGCTCGACACGCGGGTGCGGGGCGACCTCGGTGGC
  CCGCAGTTGACTCATGTTGACCAAGCAAGCTTCCAGGTTGATGCCTTTGGAACGTCATTC
  ATTCTCGATGTCGTGCTAAATCATGATTTGCTGTCCTCTGAATACATAGAGAGACACATT
  GAACATGGAGGCAAGACTGTGGAAGTTAAAGGAGGAGAGCACTGTTACTACCAGGGCCAT
  ATCCGAGGAAACCCTGACTCATTTGTTGCATTGTCAACATGCCACGGACTTCATGGGATG
  TTCTATGACGGGAACCACACATATCTCATTGAGCCAGAAGAAAATGACACTACTCAAGAG
  GATTTCCATTTTCATTCAGTTTACAAATCCAGACTGTTTGAATTTTCCTTGGATGATCTT
  CCATCTGAATTTCAGCAAGTAAACATTACTCCATCAAAATTTATTTTGAAGCCAAGACCA
  AAAAGGAGTAAACGGCAGCTTCGTCGATATCCTCGTAATGTAGAAGAAGAAACCAAATAC
  ATTGAACTGATGATTGTGAATGATCACCTTATGTTTAAAAAACATCGGCTTTCCGTTGTA
  CATACCAATACCTATGCGAAATCTGTGGTGAACATGGCAGATTTAATATATAAAGACCAA
  CTTAAGACCAGGATAGTATTGGTTGCTATGGAAACCTGGGCGACTGACAACAAGTTTGCC
  ATATCTGAAAATCCATTGATCACCCTACGTGAGTTTATGAAATACAGGAGGGATTTTATC
  AAAGAGAAAAGTGATGCAGTTCACCTTTTTTCGGGAAGTCAATTTGAGAGTAGCCGGAGC
  GGGGCAGCTTATATTGGTGGGATTTGCTCGTTGCTGAAAGGAGGAGGCGTGAATGAATTT
  GGGAAAACTGATTTAATGGCTGTTACACTTGCCCAGTCATTAGCCCATAATATTGGTATT
  ATCTCAGACAAAAGAAAGTTAGCAAGTGGTGAATGTAAATGCGAGGACACGTGGTCCGGG
  TGCATAATGGGAGACACTGGCTATTATCTTCCTAAAAAGTTCACCCAGTGTAATATTGAA
  GAGTATCATGACTTCCTGAATAGTGGAGGTGGTGCCTGCCTTTTCAACAAACCTTCTAAG
  CTTCTTGATCCTCCTGAGTGTGGCAATGGCTTCATTGAAACTGGAGAGGAGTGTGATTGT
  GGAACCCCGGCCGAATGTGTCCTTGAAGGAGCAGAGTGTTGTAAGAAATGCACCTTGACT
  CAAGACTCTCAATGCAGTGACGGTCTTTGCTGTAAAAAGTGCAAGTTTCAGCCTATGGGC
  ACTGTGTGCCGAGAAGCAGTAAATGATTGTGATATTCGTGAAACGTGCTCAGGAAATTCA
  AGCCAGTGTGCCCCTAATATTCATAAAATGGATGGATATTCATGTGATGGTGTTCAGGGA
  ATTTGCTTTGGAGGAAGATGCAAAACCAGAGATAGACAATGCAAATACATTTGGGGGCAA
  AAGGTGACAGCATCAGACAAATATTGCTATGAGAAACTGAATATTGAAGGGACGGAGAAG
  GGTAACTGTGGGAAAGACAAAGACACATGGATACAGTGCAACAAACGGGATGTGCTTTGT
  GGTTACCTTTTGTGTACCAATATTGGCAATATCCCAAGGCTTGGAGAACTCGATGGTGAA
  ATCACATCTACTTTAGTTGTGCAGCAAGGAAGAACATTAAACTGCAGTGGTGGGCATGTT
  AAGCTTGAAGAAGATGTAGATCTTGGCTATGTGGAAGATGGGACACCTTGTGGTCCCCAA
  ATGATGTGCTTAGAACACAGGTGTCTTCCTGTGGCTTCTTTCAACTTTAGTACTTGCTTG
  AGCAGTAAAGAAGGCACTATTTGCTCAGGAAATGGAGTTTGCAGTAATGAGCTGAAGTGT
  GTGTGTAACAGACACTGGATAGGTTCTGATTGCAACACTTACTTCCCTCACAATGATGAT
  GCAAAGACTGGTATCACTCTGTCTGGCAATGGTGTTGCTGGCACCAATATCATAATAGGC
  ATAATTGCTGGCACCATTTTAGTGCTGGCCCTCATATTAGGAATAACTGCGTGGGGTTAT
  AAAAACTATCGAGAACAGAGACAGTTACCCCAGGGAGATTATGTAAAAAAGCCTGGAGAT
  GGTGACTCTTTTTATAGCGACATTCCTCCCGGAGTCAGCACAAACTCAGCATCTAGTTCT
  AAGAAGAGGTCAAATGGGCTCTCTCATTCTTGGAGTGAAAGGATTCCAGACACAAAACAT
  ATTTCAGACATCTGTGAAAATGGGCGACCTCGAAGTAACTCTTGGCAAGGTAACCTGGGA
  GGCAACAAAAAGAAAATCAGAGGCAAAAGATTTAGACCTCGGTCTAATTCAACTGAG
  
• Restriction Sites: Please inquire
• ACCN: NM_004194
• ORF Size: 2580 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_004194.2, NP_004185.1
• RefSeq Size: 2744
• RefSeq ORF: 2580
• Locus ID: 53616
• Domains: Reprolysin, DISIN, Pep_M12B_propep, ACR
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants. [provided by RefSeq, Dec 2010]
  Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.