PTPRN2 (NM_130842) Human Untagged Clone

CAT#: SC315054

PTPRN2 (untagged)-Human protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRN2
• Synonyms: IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_130842, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGGGCCGCCGCTCCCGCTGCTGCTGCTGCTACTGCTGCTGCTGCCGCCACGCGTCCTGCCTGCCGCCC
  CTTCGTCCGTCCCCCGCGGCCGGCAGCTCCCGGGGCGTCTGGATGGAGTGTTTGGAAGGTGCCAGAAGGT
  TCCGGCAATGGACTTTTACCGCTACGAGGTGTCGCCCGTGGCCCTGCAGCGCCTGCGCGTGGCGTTGCAG
  AAGCTTTCCGGCACAGGTTTCACGTGGCAGGATGACTATACTCAGTATGTGATGGACCAGGAACTTGCAG
  ACCTCCCGAAAACCTACCTGAGGCGTCCTGAAGCATCCAGCCCAGCCAGGCCCTCAAAACACAGCGTTGG
  CAGCGAGAGGAGGTACAGTCGGGAGGGCGGTGCTGCCCTGGCCAACGCCCTCCGACGCCACCTGCCCTTC
  CTGGAGGCCCTGTCCCAGGCCCCAGCCTCAGACGTGCTCGCCAGGACCCATACGGCGCAGGACAGACCCC
  CCGCTGAGGGTGATGACCGCTTCTCCGAGAGCATCCTGACCTATGTGGCCCACACGTCTGCGCTGACCTA
  CCCTCCCGGGTCCCGGACCCAGCTCCGCGAGGACCTCCTGCCGCGGACCCTCGGCCAGCTCCAGCCAGAT
  GAGCTCAGCCCTAAGGTGGACAGTGGTGTGGACAGACACCATCTGATGGCGGCCCTCAGTGCCTATGCTG
  CCCAGAGGCCCCCAGCTCCCCCCGGGGAGGGCAGCCTGGAGCCACAGTACCTTCTGCGTGCACCCTCAAG
  AATGCCCAGGCCTTTGCTGGCACCAGCCGCCCCCCAGAAGTGGCCTTCACCTCTGGGAGATTCCGAAGAC
  CCCTCCAGCACAGGCGATGGAGCACGGATTCATACCCTCCTGAAGGACCTGCAGAGGCAGCCGGCTGAGG
  TGAGGGGCCTGAGTGGCCTGGAGCTGGACGGCATGGCTGAGCTGATGGCTGGCCTGATGCAAGGCGTGGA
  CCATGGAGTAGCTCGAGGCAGCCCTGGGAGAGCGGCCCTGGGAGAGTCTGGAGAACAGGCGGATGGCCCC
  AAGGCCACCCTCCGTGGAGACAGCTTTCCAGATGACGGAGTGCAGGACGACGATGATAGACTTTACCAAG
  AGGTCCATCGTCTGAGTGCCACACTCGGGGGCCTCCTGCAGGACCACGGGTCTCGACTCTTACCTGGAGC
  CCTCCCCTTTGCAAGGCCCCTCGACATGGAGAGGAAGAAGTCCGAGCACCCTGAGTCTTCCCTGTCTTCA
  GAAGAGGAGACTGCCGGAGTGGAGAACGTCAAGAGCCAGACGTATTCCAAAGATCTGCTGGGGCAGCAGC
  CGCATTCGGAGCCCGGGGCCGCTGCGTTTGGGGAGCTCCAAAACCAGATGCCTGGGCCCTCGAAGGAGGA
  GCAGAGCCTTCCAGCGGGTGCTCAGGAGGCCCTCAGCGACGGCCTGCAATTGGAGGTCCAGCCTTCCGAG
  GAAGAGGCGCGGGGCTACATCGTGACAGACAGAGACCCCCTGCGCCCCGAGGAAGGAAGGCGGCTGGTGG
  AGGACGTCGCCCGCCTCCTGCAGGTGCCCAGCAGTGCGTTCGCTGACGTGGAGGTTCTCGGACCAGCAGT
  GACCTTCAAAGTGAGCGCCAATGTCCAAAACGTGACCACTGAGGATGTGGAGAAGGCCACAGTTGACAAC
  AAAGACAAACTGGAGGAAACCTCTGGACTGAAAATTCTTCAAACCGGAGTCGGGTCGAAAAGCAAACTCA
  AGTTCCTGCCTCCTCAGGCGGAGCAAGAAGACTCCACCAAGTTCATCGCGCTCACCCTGGTCTCCCTCGC
  CTGCATCCTGGGCGTCCTCCTGGCCTCTGGCCTCATCTACTGCCTCCGCCATAGCTCTCAGCACAGGCTG
  AAGGAGAAGCTCTCGGGACTAGGGGGCGACCCAGGTGCAGATGCCACTGCCGCCTACCAGGAGCTGTGCC
  GCCAGCGTATGGCCACGCGGCCACCAGACCGACCTGAGGGCCCGCACACGTCACGCATCAGCAGCGTCTC
  ATCCCAGTTCAGCGACGGGCCGATCCCCAGCCCCTCCGCACGCAGCAGCGCCTCATCCTGGTCCGAGGAG
  CCTGTGCAGTCCAACATGGACATCTCCACCGGCCACATGATCCTGTCCTACATGGAGGACCACCTGAAGA
  ACAAGAACCGGCTGGAGAAGGAGTGGGAAGCGCTGTGCGCCTACCAGGCGGAGCCCAACAGCTCGTTCGT
  GGCCCAGAGGGAGGAGAACGTGCCCAAGAACCGCTCCCTGGCCGTGCTGACCTATGACCACTCCCGGGTC
  CTGCTGAAGGCGGAGAACAGCCACAGCCACTCAGACTACATCAACGCTAGCCCCATCATGGATCACGACC
  CGAGGAACCCCGCGTACATCGCCACCCAGGGACCGCTGCCCGCCACCGTGGCTGACTTTTGGCAGATGGT
  GTGGGAGAGCGGCTGCGTGGTGATCGTCATGCTGACACCCCTCGCGGAGAACGGCGTCCGGCAGTGCTAC
  CACTACTGGCCGGATGAAGGCTCCAATCTCTACCACATCTATGAGGTGAACCTGGTCTCCGAGCACATCT
  GGTGTGAGGACTTCCTGGTGAGGAGCTTCTATCTGAAGAACCTGCAGACCAACGAGACGCGCACCGTGAC
  GCAGTTCCACTTCCTGAGTTGGTATGACCGAGGAGTCCCTTCCTCCTCAAGGTCCCTCCTGGACTTCCGC
  AGAAAAGTAAACAAGTGCTACAGGGGCCGTTCTTGTCCAATAATTGTTCATTGCAGTGACGGTGCAGGCC
  GGAGCGGCACCTACGTCCTGATCGACATGGTTCTCAACAAGATGGCCAAAGGTGCTAAAGAGATTGATAT
  CGCAGCGACCCTGGAGCACTTGAGGGACCAGAGACCCGGCATGGTCCAGACGAAGGAGCAGTTTGAGTTC
  GCGCTGACAGCCGTGGCTGAGGAGGTGAACGCCATCCTCAAGGCCCTTCCCCAGTGA
  
  
• Restriction Sites: SgfI-RsrII
• ACCN: NM_130842
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_130842.3, NP_570857.2
• RefSeq Size: 4808 bp
• RefSeq ORF: 2997 bp
• Locus ID: 5799
• Cytogenetics: 7q36.3
• Domains: Y_phosphatase, PTPc_motif
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Type I diabetes mellitus
• Gene Summary: 'This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]'
  Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.