DOT1L (NM_032482) Human Untagged Clone

CAT#: SC315370

DOT1L (untagged)-Human DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DOT1L
• Synonyms: DOT1; KMT4
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_032482 edited
  GGCACGAGGCGGGCCTGTGACTACAAAGAGGGAGTCGGGGGCCGGGCCGGACCGGAGCGC
  GGCGGCGGCGGCGGCGGCGGCCGAGGCCGAGGCCAGGCCCCCTCCCCTCAGCCTCCCGCC
  CCTCCCTCCCGCCCGCCCTCCTCCGCCCACCGGCGGCCCCGCCCCTCCCCCAACCGCCCG
  CCTAGCATGGTGCGGCGGCCGCGCGCGCGGACATGGGGGAGAAGCTGGAGCTGAGACTGA
  AGTCGCCCGTGGGGGCTGAGCCCGCCGTCTACCCGTGGCCGCTGCCGGTCTACGCTAAAC
  ATCACGATGCTGCTCATGAAATCATCGAGACCATCCGATGGGTCTGTGAAGAAATCCCGG
  ATCTCAAGCTCGCTATGGAGAATTACGTTTTAATTGACTATGACACCAAAAGCTTCGAGA
  GCATGCAGAGGCTCTGCGACAAGTACAACCGTGCCATCGACAGCATCCACCAGCTGTGGA
  AGGGCACCACGCAGCCCATGAAGCTGAACACGCGGCCGTCCACTGGACTCCTGCGCCATA
  TCCTGCAGCAGGTCTACAACCACTCGGTGACCGACCCCGAGAAGCTCAACAACTACGAGC
  CCTTCTCCCCCGAGGTGTACGGGGAGACCTCCTTCGACCTGGTGGCCCAGATGATTGATG
  AGATCAAGATGACCGACGACGACCTGTTTGTGGACTTGGGGAGCGGTGTGGGCCAGGTCG
  TGCTCCAGGTTGCTGCTGCCACCAACTGCAAACATCACTATGGCGTCGAGAAAGCAGACA
  TCCCGGCCAAGTATGCGGAGACCATGGACCGCGAGTTCAGGAAGTGGATGAAATGGTATG
  AAAAAAAGCATGCAGAATACACATTGGAGAGAGGCGATTTCCTCTCAGAAGAGTGGAGGG
  AGCGAATCGCCAACACGAGTGTTATATTTGTGAATAATTTTGCCTTTGGTCCTGAGGTGG
  ATCACCAGCTGAAGGAGCGGTTTGCAAACATGAAGGAAGGTGGCAGAATCGTGTCCTCGA
  AACCCTTTGCACCTCTGAACTTCAGAATAAACAGTAGAAACTTGAGTGACATCGGCACCA
  TCATGCGCGTGGTGGAGCTCTCGCCCCTGAAGGGCTCGGTGTCGTGGACGGGGAAGCCAG
  TCTCCTACTACCTGCACACTATCGACCGCACCATACTTGAAAACTATTTTTCTAGTCTGA
  AAAACCCAAAACTCAGGGAGGAACAGGAGGCAGCCCGGCGCCGCCAGCAGCGCGAGAGCA
  AGAGCAACGCGGCCACGCCCACTAAGGGCCCAGAGGGCAAGGTGGCCGGCCCCGCCGACG
  CCCCCATGGACTCTGGTGCTGAGGAAGAGAAGGCGGGAGCAGCCACCGTGAAGAAGCCGT
  CTCCCTCCAAAGCCCGCAAGAAGAAGCTAAACAAGAAGGGGAGGAAGATGGCTGGCCGCA
  AGCGCGGGCGCCCCAAGAAGATGAACACTGCGAACCCCGAGCGGAAGCCCAAGAAGAACC
  AAACTGCACTGGATGCCCTGCACGCTCAGACCGTGTCTCAGACGGCGGCCTCCTCACCCC
  AGGATGCCTACAGATCCCCTCACAGCCCGTTCTACCAGCTACTTCCGAGCGTGCAGCGGC
  ACTCCCCCAACCCGCTGCTGGTGGCGCCCACCCCGCCCGCGCTGCAGAAGCTTCTAGAGT
  CCTTCAAGATCCAGTACCTGCAGTTCCTGGCATACACAAAGACCCCCCAGTACAAGGCCA
  GCCTGCAGGAGCTGCTGGGCCAGGAGAAGGAGAAGAACGCCCAGCTCCTGGGTGCGGCTC
  AGCAGCTCCTCAGCCACTGCCAGGCCCAGAAGGAGGAGATCAGGAGGCTGTTTCAGCAAA
  AATTGGATGAGCTGGGTGTGAAGGCGCTGACCTACAACGACCTGATTCAAGCGCAGAAGG
  AGATCTCCGCCCATAACCAGCAGCTGCGGGAGCAGTCGGAGCAGCTGGAGCAGGACAACC
  GCGCGCTCCGCGGCCAGAGCTTGCAGCTGCTCAAGGCTCGCTGCGAGGAGCTGCAGCTGG
  ACTGGGCCACGCTGTCGCTGGAGAAGCTGTTGAAGGAGAAGCAGGCCCTGAAGAGCCAGA
  TCTCGGAGAAGCAGAGGCACTGCCTGGAGCTGCAGATCAGCATTGTGGAGCTAGAGAAGA
  GCCAGCGGCAGCAGGAGCTCCTGCAGCTCAAGTCCTGTGTGCCGCCTGACGACGCCCTGT
  CCCTGCACCTGCGTGGGAAGGGCGCCCTGGGCCGCGAGCTGGAGCCTGACGCCAGCCGGC
  TGCACCTGGAGCTGGACTGCACCAAGTTCTCGCTGCCTCACTTGAGCAGCATGAGCCCGG
  AGCTCTCCATGAACGGCCAGGCTGCTGGCTATGAGCTCTGCGGTGTGCTGAGCCGGCCTT
  CGTCGAAGCAGAACACGCCCCAGTACCTGGCCTCACCCCTGGACCAGGAGGTGGTGCCCT
  GTACCCCTAGCCACGTCGGCCGGCCGCGCCTGGAGAAGCTGTCTGGCCTAGCCGCACCCG
  ACTACACTAGGCTGTCCCCGGCCAAGATTGTGCTGAGGCGGCACCTGAGCCAGGACCACA
  CGGTGCCCGGCAGGCCGGCTGCCAGTGAGCTGCATTCGAGAGCTGAGCACACCAAGGAGA
  ACGGCCTTCCCTACCAGAGCCCCAGCGTGCCTGGCAGCATGAAGCTGAGCCCTCAGGACC
  CGCGGCCCCTGTCCCCTGGGGCCTTGCAGCTTGCTGGAGAGAAGAGCAGTGAGAAGGGCC
  TGAGAGAGCGCGCCTACGGCAGCAGCGGGGAGCTCATCACCAGCCTGCCCATCAGCATCC
  CGCTCAGCACCGTGCAGCCCAACAAGCTCCCGGTCAGCATTCCCCTGGCCAGCGTGGTGC
  TGCCCAGCCGCGCCGAGAGGGCGAGGAGCACCCCCAGTCCCGTGCTGCAGCCCCGTGACC
  CCTCGTCCACACTTGAAAAGCAGATTGGTGCTAATGCCCACGGTGCTGGGAGCAGAAGCC
  TTGCCCTGGCCCCCGCAGGCTTCTCCTACGCTGGCTCGGTGGCCATCAGCGGGGCCTTGG
  CGGGCAGCCCGGCCTCTCTCACACCTGGAGCCGAGCCGGCCACCTTGGATGAGTCCTCCA
  GCTCTGGGAGCCTTTTTGCCACCGTGGGGTCCCGCAGCTCCACGCCACAGCACCCCCTGC
  TGCTGGCACAGCCCCGGAACTCGCTTCCTGCCTCTCCCGCCCACCAGCTCTCCTCCAGTC
  CCCGGCTTGGTGGGGCCGCCCAGGGCCCGTTGCCCGAGGCCAGCAAGGGAGACCTGCCCT
  CCGATTCCGGCTTCTCAGATCCTGAGAGTGAAGCCAAGAGGAGGATTGTGTTCACCATCA
  CCACTGGTGCGGGCAGTGCCAAGCAGTCGCCCTCCAGCAAGCACAGCCCCCTGACCGCCA
  GCGCCCGTGGGGACTGTGTGCCGAGCCACGGGCAGGACAGTCGCAGGCGCGGCCGGCGGA
  AGCGAGCATCTGCGGGGACGCCCAGCTTGAGCGCAGGCGTGTCCCCCAAGCGCCGAGCCC
  TGCCGTCCGTCGCTGGCCTTTTCACACAGCCTTCGGGGTCTCCCCTCAACCTCAACTCCA
  TGGTCAGTAACATCAACCAGCCCCTGGAGATTACAGCCATCTCGTCCCCGGAGACCTCCC
  TGAAGAGCTCCCCTGTGCCCTACCAGGACCACGACCAGCCCCCCGTGCTCAAGAAGGAGC
  GGCCTCTGAGCCAGACCAATGGGGCACACTACTCCCCACTCACCTCAGACGAGGAGCCAG
  GCTCTGAGGACGAGCCCAGCAGTGCTCGAATTGAGAGAAAAATTGCAACAATCTCCTTAG
  AAAGCAAATCTCCCCCGAAAACCTTGGAAAATGGTGGTGGCTTGGCGGGAAGGAAGCCCG
  CGCCCGCCGGCGAGCCAGTCAATAGCAGCAAGTGGAAGTCCACCTTCTCGCCCATCTCCG
  ACATCGGCCTGGCCAAGTCGGCGGACAGCCCGCTGCAGGCCAGCTCCGCCCTCAGCCAGA
  ACTCCCTGTTCACGTTCCGGCCCGCCCTGGAGGAGCCCTCTGCCGATGCCAAGCTGGCCG
  CTCACCCCAGGAAAGGCTTTCCCGGCTCCCTGTCGGGGGCTGACGGACTCAGCCCGGGCA
  CCAACCCTGCCAACGGCTGCACCTTCGGCGGGGGCCTGGCCGCGGACCTGAGTTTACACA
  GCTTCAGTGATGGTGCTTCTCTTCCCCACAAGGGCCCCGAGGCGGCCGGCCTGAGCTCCC
  CGCTGAGCTTCCCCTCGCAGCGCGGCAAGGAGGGCTCGGACGCCAACCCTTTCCTGAGCA
  AGAGGCAGCTGGACGGCCTGGCTGGGCTGAAGGGCGAGGGCAGCCGCGGCAAGGAGGCAG
  GGGAGGGCGGCCTACCGCTGTGCGGGCCCACGGACAAGACCCCACTGCTGAGCGGCAAGG
  CCGCCAAGGCCCGGGACCGCGAGGTCGACCTCAAGAATGGCCACAACCTCTTCATCTCTG
  CGGCGGCCGTGCCTCCCGGAAGCCTCCTCAGCGGCCCCGGCCTGGCCCCGGCGGCGTCCT
  CCGCAGGCGGCGCGGCGTCCTCCGCCCAGACGCACCGGTCCTTCCTGGGCCCCTTCCCGC
  CGGGACCGCAGTTCGCGCTCGGCCCCATGTCCCTGCAGGCCAACCTCGGCTCCGTGGCCG
  GCTCCTCCGTGCTGCAGTCGCTGTTCAGCTCTGTGCCGGCCGCCGCAGGCCTGGTGCACG
  TGTCGTCCGCTGCCACCAGACTGACCAACTCGCACGCCATGGGCAGCTTTTCCGGGGTGG
  CAGGCGGCACAGTTGGAGGTAACTAGGATTTCTACCTCAACCGCGAGACCTATGCAAGGA
  CGGTGTGGACCAACTCGCGCCCGCGGCATGGTGCCCGCCGGCCTGCCGGGCTCCCACCCC
  TGGACGGCAGAGGCAAGGACGGACGGGAGCTCCACTGTGAATCGGCGGCACGCGCCGCAG
  GAGGCTGGGACTGGTCCAGTTTGTACTGTCGATAGTTTTAGATAAAGTATTTATCATTTT
  TTAAAAAGTATAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_032482
• ORF Size: 4614 bp
• Insert Size: 5100
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a good match to the protein associated to this reference except for a few SNPs.

Reference Data

• RefSeq: NM_032482.1, NP_115871.1
• RefSeq Size: 4889
• RefSeq ORF: 4614
• Locus ID: 84444
• Domains: AT_hook
• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation
• Gene Summary: The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]