Constitutive androstane receptor (NR1I3) (NM_001077482) Human Untagged Clone

CAT#: SC315540

NR1I3 (untagged)-Human nuclear receptor subfamily 1, group I, member 3 (NR1I3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NR1I3
• Synonyms: CAR; CAR1; MB67
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001077482 edited
  ATGGCCAGTAGGGAAGATGAGCTGAGGAACTGTGTGGTATGTGGGGACCAAGCCACAGGC
  TACCACTTTAATGCGCTGACTTGTGAGGGCTGCAAGGGTTTCTTCAGGAGAACAGTCAGC
  AAAAGCATTGGTCCCACCTGCCCCTTTGCTGGAAGCTGTGAAGTCAGCAAGACTCAGAGG
  CGCCACTGCCCAGCCTGCAGGTTGCAGAAGTGCTTAGATGCTGGCATGAGGAAAGACATG
  ATACTGTCGGCAGAAGCCCTGGCATTGCGGCGAGCAAAGCAGGCCCAGCGGCGGGCACAG
  CAAACACCTGTGCAACTGAGTAAGGAGCAAGAAGAGCTGATCCGGACACTCCTGGGGGCC
  CACACCCGCCACATGGGCACCATGTTTGAACAGTTTGTGCAGTTTAGGCCTCCAGCTCAT
  CTGTTCATCCATCACCAGCCCTTGCCCACCCTGGCCCCTGTGCTGCCTCTGGTCACACAC
  TTCGCAGACATCAACACTTTCATGGTACTGCAAGTCATCAAGTTTACTAAGGACCTGCCC
  GTCTTCCGTTCCCTGCCCATTGAAGACCAGATCTCCCTTCTCAAGGGAGCAGCTGTGGAA
  ATCTGTCACATCGTACTCAATACCACTTTCTGTCTCCAAACACAAAACTTCCTCTGCGGG
  CCTCTTCGCTACACAATTGAAGATGGAGCCCGTGTATCTCCCACAGTGGGGTTCCAGGTA
  GAGTTTTTGGAGTTGCTCTTTCACTTCCATGGAACACTACGAAAACTGCAGCTCCAAGAG
  CCTGAGTATGTGCTCTTGGCTGCCATGGCCCTCTTCTCTCCTGCTCCCTATCTTACAGAC
  CGACCTGGAGTTACCCAGAGAGATGAGATTGATCAGCTGCAAGAGGAGATGGCACTGACT
  CTGCAAAGCTACATCAAGGGCCAGCAGCGAAGGCCCCGGGATCGGTTTCTGTATGCGAAG
  TTGCTAGGCCTGCTGGCTGAGCTCCGGAGCATTAATGAGGCCTACGGGTACCAAATCCAG
  CACATCCAGGGCCTGTCTGCCATGATGCCGCTGCTCCAGGAGATCTGCAGCTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001077482 unedited
  GTACGATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCTCATGGCCAGTAGGGAAGA
  TGAGCTGAGGAACTGTGTGGTATGTGGGGACCAAGCCACAGGCTACCACTTTAATGCGCT
  GACTTGTGAGGGCTGCAAGGGTTTCTTCAGGAGAACAGTCAGCAAAAGCATTGGTCCCAC
  CTGCCCCTTTGCTGGAAGCTGTGAAGTCAGCAAGACTCAGAGGCGCCACTGCCCAGCCTG
  CAGGTTGCAGAAGTGCTTAGATGCTGGCATGAGGAAAGACATGATACTGTCGGCAGAAGC
  CCTGGCATTGCGGCGAGCAAAGCAGGCCCAGCGGCGGGCACAGCAAACACCTGTGCAACT
  GAGTAAGGAGCAAGAAGAGCTGATCCGGACACTCCTGGGGGCCCACACCCGCCACATGGG
  CACCATGTTTGAACAGTTTGTGCAGTTTAGGCCTCCAGCTCATCTGTTCATCCATCACCA
  GCCCTTGCCCACCCTGGCCCCTGTGCTGCCTCTGGTCACACACTTCGCAGACATCAACAC
  TTTCATGGTACTGCAAGTCATCAAGTTTACTAAGGACCTGCCCGTCTTCCGTTCCCTGCC
  CATTGAAGACCAGATCTCCCTTCTCAAGGGAGCAGCTGTGGAAATCTGTCACATCGTACT
  CAATACCACTTTCTGTCTCCAAACACAAAACTTCCTCTGCGGGCCTCTTCGCTACACAAT
  TGAAGATGGAGCCCGTGTATCTCCCACAGTGGGGTTCCAGGTAGAGTTTTTGGGAGTTGC
  TCTTTCACTTTCCATGGAACACTACGAAAACTGCAGCTCCAAGAGCCTGAGTATGTGCTC
  TTGGCTGCCATGGCCCTCTTCTCTCCTGCTCCCTATCTTACAGACCGACCTGGAGTTACC
  CAGAGAGATGGAGATTGATCAGCTGCA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001077482 unedited
  TGGACGCTGCACTTCAGGGCCGGAGAGGCACCTGGGGAGGGGTCACAGGGATGCCACCCG
  GGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGATCAGCTGCAGATCTCCT
  GGAGCAGCGGCATCATGGCAGACAGGCCCTGGATGTGCTGGATTTGGTACCCGTAGGCCT
  CATTAATGCTCCGGAGCTCAGCCAGCAGGCCTAGCAACTTCGCATACAGAAACCGATCCC
  GGGGCCTTCGCTGCTGGCCCTTGATGTAGCTTTGCAGAGTCAGTGCCATCTCCTCTTGCA
  GCTGATCAATCTCATCTCTCTGGGTAACTCCAGGTCGGTCTGTAAGATAGGGAGCAGGAG
  AGAAGAGGGCCATGGCAGCCAAGAGCACATACTCAGGCTCTTGGAGCTGCAGTTTTCGTA
  GTGTTCCATGGAAGTGAAAGAGCAACTCCAAAAACTCTACCTGGAACCCCACTGTGGGAG
  ATACACGGGCTCCATCTTCAATTGTGTAGCGAAGAGGCCCGCAGAGGAAGTTTTGTGTTT
  GGAGACAGAAAGTGGTATTGAGTACGATGTGACAGATTTCCACAGCTGCTCCCTTGAGAA
  GGGAGATCTGGTCTTCAATGGGCAGGGAACGGAAGACGGGCAGGTCCTTAGTAAACTTGA
  TGACTTGCAGTACCATGAAAGTGTTGATGTCTGCGAAGTGTGTGACCAGAGGCAGCACAG
  GGGCCAGGGTGGGCAAAGGGCTGGTGATGGATGAACAGATGAGCTGGAGCCTAAACTGCA
  CAAACTGTTCAAACATGGTGCCCATGTGGCGGGTGTGGGCCCCCAGGAGTGTCCGGATCA
  GCTCTTCTTGCTCCTTACTCAGTTGCACAGGTGTTTGCTGTGCCCGCCGCTGGGCCCTGC
  TTTGCTCGC
  
• Restriction Sites: Please inquire
• ACCN: NM_001077482
• ORF Size: 1074 bp
• Insert Size: 1100
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.

Reference Data

• RefSeq: NM_001077482.1, NP_001070950.1
• RefSeq Size: 1408
• RefSeq ORF: 1074
• Locus ID: 9970
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Gene Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1), also known as SV-25 or CAR2, represents the longest transcript and encodes the longest isoform (1).