SART2 (DSE) (NM_001080976) Human Untagged Clone

CAT#: SC315973

DSE (untagged)-Human dermatan sulfate epimerase (DSE), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DSE
• Synonyms: DS-epi1; DSEP; DSEPI; EDSMC2; SART-2; SART2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001080976, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGGACTCACACACGGGGGGCTCCCAGTGTGTTTTTCATATATTTGCTTTGCTTTGTGTCAGCCTACA
  TCACCGACGAGAACCCAGAAGTTATGATTCCCTTCACCAATGCCAACTACGACAGCCATCCCATGCTGTA
  CTTCTCCAGGGCAGAAGTGGCGGAGCTGCAGCTCAGGGCTGCCAGCTCGCACGAGCACATTGCAGCCCGC
  CTCACGGAGGCTGTGCACACGATGCTGTCCAGCCCCTTGGAATACCTCCCTCCCTGGGATCCCAAGGACT
  ACAGTGCCCGCTGGAATGAAATTTTTGGAAACAACTTGGGTGCCTTGGCAATGTTCTGTGTGCTGTATCC
  TGAGAACATTGAAGCCCGAGACATGGCCAAAGACTACATGGAGAGGATGGCAGCGCAGCCTAGTTGGTTG
  GTGAAAGATGCTCCTTGGGATGAGGTCCCGCTTGCTCACTCCCTGGTTGGTTTTGCCACTGCTTATGACT
  TCTTGTACAACTACCTGAGCAAGACACAACAGGAGAAGTTTCTTGAAGTGATTGCCAATGCCTCAGGGTA
  TATGTATGAAACTTCATACAGGAGAGGATGGGGATTTCAATACCTGCACAATCATCAGCCCACCAACTGT
  ATGGCTTTGCTCACGGGAAGCCTAGTCCTGATGAATCAAGGATATCTTCAAGAAGCCTACTTATGGACCA
  AACAAGTTCTGACCATCATGGAGAAATCTCTGGTCTTGCTCAGGGAGGTGACGGATGGCTCCCTCTATGA
  AGGAGTTGCGTATGGCAGCTACACCACTAGATCACTCTTCCAATACATGTTTCTCGTCCAGAGGCACTTC
  AACATCAACCACTTTGGCCATCCGTGGCTTAAACAACACTTTGCATTTATGTATAGAACCATCCTGCCAG
  GGTTTCAAAGGACTGTGGCTATTGCGGACTCAAATTACAACTGGTTTTATGGTCCAGAAAGCCAATTAGT
  GTTCCTTGATAAATTTGTCATGCGTAATGGCAGTGGTAACTGGCTAGCTGACCAAATCAGAAGGAACCGT
  GTGGTGGAAGGTCCAGGAACACCATCCAAAGGGCAGCGCTGGTGCACTCTGCACACAGAATTTCTCTGGT
  ATGATGGCAGCTTGAAATCGGTTCCTCCTCCAGACTTTGGCACCCCTACACTGCATTATTTTGAAGACTG
  GGGTGTCGTGACTTATGGAAGTGCACTACCTGCAGAAATCAATAGATCTTTCCTTTCCTTCAAGTCTGGA
  AAACTGGGGGGACGTGCAATATATGACATTGTCCACAGAAACAAATACAAAGATTGGATCAAAGGATGGA
  GAAATTTTAATGCAGGGCATGAACATCCTGATCAAAACTCATTTACTTTTGCTCCCAATGGTGTGCCTTT
  CATTACTGAGGCTCTGTACGGGCCAAAGTACACCTTCTTCAACAATGTTTTGATGTTTTCCCCAGCTGTG
  TCAAAGAGCTGCTTTTCTCCCTGGGTGGGTCAGGTCACAGAAGACTGCTCATCAAAATGGTCTAAATACA
  AGCATGACCTGGCAGCTAGTTGTCAGGGGAGGGTGGTTGCAGCAGAGGAGAAAAATGGGGTGGTTTTCAT
  CCGAGGAGAAGGTGTGGGAGCTTATAACCCCCAGCTCAACCTGAAGAATGTTCAGAGGAATCTCATCCTC
  CTACATCCACAGCTGCTTCTCCTTGTAGACCAAATACACCTGGGAGAGGAGAGTCCCTTGGAGACAGCAG
  CGAGCTTCTTCCATAATGTGGATGTTCCTTTTGAGGAGACTGTGGTAGATGGTGTCCATGGGGCTTTCAT
  CAGGCAGAGAGATGGTCTCTATAAAATGTACTGGATGGACGATACTGGCTACAGCGAGAAAGCAACCTTT
  GCCTCAGTGACATATCCTCGGGGCTATCCCTACAACGGGACAAACTATGTGAATGTCACCATGCACCTCC
  GAAGTCCCATCACCAGGGCAGCTTACCTCTTCATAGGGCCATCTATAGATGTTCAGAGCTTCACTGTCCA
  CGGAGACTCTCAGCAACTGGATGTGTTCATAGCCACCAGCAAACATGCCTACGCCACATACCTGTGGACA
  GGTGAGGCCACAGGACAGTCTGCCTTTGCACAGGTCATTGCTGATCGTCACAAAATTCTGTTTGACCGGA
  ATTCAGCCATCAAGAGCAGCATTGTCCCTGAGGTGAAGGACTATGCTGCTATTGTGGAACAGAACTTGCA
  GCATTTTAAACCAGTGTTTCAGCTGCTGGAGAAGCAGATACTGTCCCGAGTCCGGAACACAGCTAGCTTT
  AGGAAGACTGCTGAACGCCTGCTGAGATTTTCAGATAAGAGACAGACTGAGGAGGCCATTGACAGGATTT
  TTGCCATATCACAGCAACAGCAGCAGCAAAGCAAGTCAAAGAAAAACCGAAGGGCAGGCAAACGCTATAA
  ATTTGTGGATGCTGTCCCTGATATTTTTGCACAGATTGAAGTCAATGAGAAAAAGATTAGACAGAAAGCT
  CAGATTTTGGCACAGAAAGAACTACCCATAGATGAAGATGAAGAAATGAAAGACCTTTTAGATTTTGCAG
  ATGTAACATACGAGAAACATAAAAATGGGGGCTTGATTAAAGGCCGGTTTGGACAGGCACGGATGGTGAC
  AACTACACACAGCAGGGCCCCATCACTGTCTGCTTCCTATACCAGGTTGTTCCTGATTCTGAACATTGCT
  ATTTTCTTTGTCATGTTGGCAATGCAACTGACTTATTTCCAGAGGGCCCAGAGCCTACATGGCCAAAGAT
  GTCTTTATGCAGTTCTTCTCATAGATAGCTGTATTTTATTATGGTTGTACTCTTCTTGTTCCCAATCACA
  GTGTTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001080976
• ORF Size: 2877 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001080976.2, NP_001074445.1
• RefSeq Size: 4092
• RefSeq ORF: 2877
• Locus ID: 29940
• Protein Families: Transmembrane
• Protein Pathways: Chondroitin sulfate biosynthesis
• Gene Summary: The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same isoform (a).