NCOA2 (NM_006540) Human Untagged Clone

CAT#: SC316986

NCOA2 (untagged)-Human nuclear receptor coactivator 2 (NCOA2)


  "NM_006540" in other vectors (6)

Reconstitution Protocol

SC316986 is the updated version of SC315653.

USD 1,100.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol NCOA2
Synonyms bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2
Vector pCMV6-XL6
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_006540 edited
CCGAGCCGATTTCTCTTGGATTTGGCTACACACTTATAGATCTTCTGCACTGTTTACAGG
CACAGTTGCTGATATGTGTTCAAGATGAGTGGGATGGGAGAAAATACCTCTGACCCCTCC
AGGGCAGAGACAAGAAAGCGCAAGGAATGTCCTGACCAACTTGGACCCAGCCCCAAAAGG
AACACTGAAAAACGTAATCGTGAACAGGAAAATAAATATATAGAAGAACTTGCAGAGTTG
ATTTTTGCAAATTTTAATGATATAGACAACTTTAACTTCAAACCTGACAAATGTGCAATC
TTAAAAGAAACTGTGAAGCAAATTCGTCAGATCAAAGAACAAGAGAAAGCAGCAGCTGCC
AACATAGATGAAGTGCAGAAGTCAGATGTATCCTCTACAGGGCAGGGTGTCATCGACAAG
GATGCGCTGGGGCCTATGATGCTTGAGGCCCTTGATGGGTTCTTCTTTGTAGTGAACCTG
GAAGGCAACGTTGTGTTTGTGTCAGAGAATGTGACACAGTATCTAAGGTATAACCAAGAA
GAGCTGATGAACAAAAGTGTATATAGCATCTTGCATGTTGGGGACCACACGGAATTTGTC
AAAAACCTGCTGCCAAAGTCTATAGTAAATGGGGGATCTTGGTCTGGCGAACCTCCGAGG
CGGAACAGCCATACCTTCAATTGTCGGATGCTGGTAAAACCTTTACCTGATTCAGAAGAG
GAGGGTCATGATAACCAGGAAGCTCATCAGAAATATGAAACTATGCAGTGCTTCGCTGTC
TCTCAACCAAAGTCCATCAAAGAAGAAGGAGAAGATTTGCAGTCCTGCTTGATTTGCGTG
GCAAGAAGAGTTCCCATGAAGGAAAGACCAGTTCTTCCCTCATCAGAAAGTTTTACTACT
CGCCAGGATCTCCAAGGCAAGATCACGTCTCTGGATACCAGCACCATGAGAGCAGCCATG
AAACCAGGCTGGGAGGACCTGGTAAGAAGGTGTATTCAGAAGTTCCATGCGCAGCATGAA
GGAGAATCTGTGTCCTATGCTAAGAGGCATCATCATGAAGTACTGAGACAAGGATTGGCA
TTCAGTCAAATCTATCGTTTTTCCTTGTCTGATGGCACTCTTGTTGCTGCACAAACGAAG
AGCAAACTCATCCGTTCTCAGACTACTAATGAACCTCAACTTGTAATATCTTTACATATG
CTTCACAGAGAGCAGAATGTGTGTGTGATGAATCCGGATCTGACTGGACAAACGATGGGG
AAGCCACTGAATCCAATTAGCTCTAACAGCCCTGCCCATCAGGCCCTGTGCAGTGGGAAC
CCAGGTCAGGACATGACCCTCAGTAGCAATATAAATTTTCCCATAAATGGCCCAAAGGAA
CAAATGGGCATGCCCATGGGCAGGTTTGGTGGTTCTGGGGGAATGAACCATGTGTCAGGC
ATGCAAGCAACCACTCCTCAGGGTAGTAACTATGCACTCAAAATGAACAGCCCCTCACAA
AGCAGCCCTGGCATGAATCCAGGACAGCCCACCTCCATGCTTTCACCAAGGCATCGCATG
AGCCCTGGAGTGGCTGGCAGCCCTCGAATCCCACCCAGTCAGTTTTCCCCTGCAGGAAGC
TTGCATTCCCCTGTGGGAGTTTGCAGCAGCACAGGAAATAGCCATAGTTATACCAACAGC
TCCCTCAATGCACTTCAGGCCCTCAGCGAGGGGCACGGGGTCTCATTAGGGTCATCGTTG
GCTTCACCAGACCTAAAAATGGGCAATTTGCAAAACTCCCCAGTTAATATGAATCCTCCC
CCACTCAGCAAGATGGGAAGCTTGGACTCAAAAGACTGTTTTGGACTATATGGGGAGCCC
TCTGAAGGTACAACTGGACAAGCAGAGAGCAGCTGCCATCCTGGAGAGCAAAAGGAAACA
AATGACCCCAACCTGCCCCCGGCCGTGAGCAGTGAGAGAGCTGACGGGCAGAGCAGACTG
CATGACAGCAAAGGGCAGACCAAACTCCTGCAGCTGCTGACCACCAAATCTGATCAGATG
GAGCCCTCGCCCTTAGCCAGCTCTTTGTCGGATACAAACAAAGACTCCACAGGTAGCTTG
CCTGGTTCTGGGTCTACACATGGAACCTCGCTCAAGGAGAAGCATAAAATTTTGCACAGA
CTCTTGCAGGACAGCAGTTCCCCTGTGGACTTGGCCAAGTTAACAGCAGAAGCCACAGGC
AAAGACCTGAGCCAGGAGTCCAGCAGCACAGCTCCTGGATCAGAAGTGACTATTAAACAA
GAGCCGGTGAGCCCCAAGAAGAAAGAGAATGCACTACTTCGCTATTTGCTAGATAAAGAT
GATACTAAAGATATTGGTTTACCAGAAATAACCCCCAAACTTGAGAGACTGGACAGTAAG
ACAGATCCTGCCAGTAACACAAAATTAATAGCAATGAAAACTGAGAAGGAGGAGATGAGC
TTTGAGCCTGGTGACCAGCCTGGCAGTGAGCTGGACAACTTGGAGGAGATTTTGGATGAT
TTGCAGAATAGTCAATTACCACAGCTTTTCCCAGACACGAGGCCAGGCGCCCCTGCTGGA
TCAGTTGACAAGCAAGCCATCATCAATGACCTCATGCAACTCACAGCTGAAAACAGCCCT
GTCACACCTGTTGGAGCCCAGAAAACAGCACTGCGAATTTCACAGAGCACTTTTAATAAC
CCACGACCAGGGCAACTGGGCAGGTTATTGCCAAACCAGAATTTACCACTTGACATCACA
TTGCAAAGCCCAACTGGTGCTGGACCTTTCCCACCAATCAGAAACAGTAGTCCCTACTCA
GTGATACCTCAGCCAGGAATGATGGGTAATCAAGGGATGATAGGAAACCAAGGAAATTTA
GGGAACAGTAGCACAGGAATGATTGGTAACAGTGCTTCTCGGCCTACTATGCCATCTGGA
GAATGGGCACCGCAGAGTTCGGCTGTGAGAGTCACCTGTGCTGCTACCACCAGTGCCATG
AACCGGCCAGTCCAAGGAGGTATGATTCGGAACCCAGCAGCCAGCATCCCCATGAGGCCC
AGCAGCCAGCCTGGCCAAAGACAGACGCTTCAGTCTCAGGTCATGAATATAGGGCCATCT
GAATTAGAGATGAACATGGGGGGACCTCAGTATAGCCAACAACAAGCTCCTCCAAATCAG
ACTGCCCCATGGCCTGAAAGCATCCTGCCTATAGACCAGGCGTCTTTTGCCAGCCAAAAC
AGGCAGCCATTTGGCAGTTCTCCAGATGACTTGCTATGTCCACATCCTGCAGCTGAGTCT
CCGAGTGATGAGGGAGCTCTCCTGGACCAGCTGTATCTGGCCTTGCGGAATTTTGATGGC
CTGGAGGAGATTGATAGAGCCTTAGGAATACCCGAACTGGTCAGCCAGAGCCAAGCAGTA
GATCCAGAACAGTTCTCAAGTCAGGATTCCAACATCATGCTGGAGCAGAAGGCGCCCGTT
TTCCCACAGCAGTATGCATCTCAGGCACAAATGGCCCAGGGTAGCTATTCTCCCATGCAA
GATCCAAACTTTCACACCATGGGACAGCGGCCTAGTTATGCCACACTCCGTATGCAGCCC
AGACCGGGCCTCAGGCCCACGGGCCTAGTGCAGAACCAGCCAAATCAACTAAGACTTCAA
CTTCAGCATCGCCTCCAAGCACAGCAGAATCGCCAGCCACTTATGAATCAAATCAGCAAT
GTTTCCAATGTGAACTTGACTCTGAGGCCTGGAGTACCAACACAGGCACCTATTAATGCA
CAGATGCTGGCCCAGAGACAGAGGGAAATCCTGAACCAGCATCTTCGACAGAGACAAATG
CATCAGCAACAGCAAGTTCAGCAACGAACTTTGATGATGAGAGGACAAGGGTTGAATATG
ACACCAAGCATGGTGGCTCCTAGTGGTATCCCAGCAACTATGAGCAACCCTCGGATTCCC
CAGGCAAATGCACAGCAGTTTCCATTTCCTCCAAACTACGGAATAAGTCAGCAACCTGAT
CCAGGCTTTACTGGGGCTACGACTCCCCAGAGCCCACTTATGTCACCCCGAATGGCACAT
ACACAGAGTCCCATGATGCAACAGTCTCAGGCCAACCCAGCCTATCAGGCCCCCTCCGAC
ATAAATGGATGGGCGCAGGGGAACATGGGCGGAAACAGCATGTTTTCCCAGCAGTCCCCA
CCACACTTTGGGCAGCAAGCAAACACCAGCATGTACAGTAACAACATGAACATCAATGTG
TCCATGGCGACCAACACAGGTGGCATGAGCAGCATGAACCAGATGACAGGACAGATCAGC
ATGACCTCAGTGACCTCCGTGCCTACGTCAGGGCTGTCCTCCATGGGTCCCGAGCAGGTT
AATGATCCTGCTCTGAGGGGAGGCAACCTGTTCCCAAACCAGCTGCCTGGAATGGATATG
ATTAAGCAGGAGGGAGACACAACACGGAAATATTGCTGACACTGCTGAAGCCAGTTGCTT
CTTCAGCTGACCGGGCTCACTTGCTCAAAACACTTCCAGTCTGGAGAGCTGTGTCTATTT
GTTTCAACCCAACTGACCTGCCA
Restriction Sites Please inquire     
ACCN NM_006540
ORF Size 4395 bp
Insert Size 4600
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF of NM_006540.2 which changes the protein from a MET to a Ile at 4008bp. OriGene considers this to be a polymorphism and to reflect the natural differences between individuals.
Reference Data
RefSeq NM_006540.2, NP_006531.1
RefSeq Size 6157
RefSeq ORF 4395
Locus ID 10499
Domains PAS, HLH
Protein Families Druggable Genome
Gene Summary The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.

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