PTPRB (NM_001109754) Human Untagged Clone

CAT#: SC317179

PTPRB (untagged)-Human protein tyrosine phosphatase, receptor type, B (PTPRB), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRB
• Synonyms: HPTP-BETA; HPTPB; PTPB; R-PTP-BETA; VEPTP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001109754, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGGTTTCAGATTG
  TCCATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTGGGCTCATGCAACAGGACCAT
  CCAGAACCAGCAGTGGATGTGGACTGAGGATGAAAAGCTCCTTCATGTTAAATCTGCACTGTGCTTGGCC
  ATCTCCAACTCTTCCCGCGGCCCCTCCCGCTCAGCCATCTTGGACCGCTGTTCCCAGGCACCCCGATGGA
  CCTGCTATGATCAGGAAGGCTTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAG
  AGTAGTGGTCAAGAAGGCCAGGAAATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAA
  CTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTCGGTGAGGAGCACTAGAA
  ACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGCCTGGTATTCCTTATTAGGAA
  TACCACAGAGGCCTTCATCAGAAATGCTGCAGAAAACTACAGCCAAAACAGCAGCGAGAGGCAGCATCCC
  AATCTGCACATGACTGGAATTACAGACACATCATGGGTTTTGTCGACTACTCAGCCCTTCTCCAGCACCA
  CTGAAGAGACTGGACTGGCGGAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCA
  TTCTGTGTCTATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACC
  CTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGACAACACCACATACGGATGTAACCTTCAAGATTTAC
  AAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGAACAGTGGTCTTGCAAACAGA
  TCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAGACGACTTCAACCAGCTTGCATGTTTGGTGG
  ACTCCTTCTTCCGGAAAAGTCACCTCATATGAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGG
  GGGTTCAAATTCAAGAAAGTACTTCATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATA
  CAATATTGCCATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTG
  CCATCTCCAGTGAAAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGGTCCCATGGTT
  CTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGATCCTAGTTCATGGCGGTGTTGTGGA
  CAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCTGGCTACCTCTACAACCTCACTGTTATGACT
  GAGGCTGCAGGGCTGCAAAACTACAGGTGGAAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGA
  AGGTGACAAATGATGGCAGTTTGACCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTC
  TTACAATATCACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAA
  ACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCTGGTGAACTGT
  CTGCTCAGAAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTTGCAAACCTGGAGGCAAACAATAATGG
  CAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCTGGAGACTGGGAGCAGTATCGGATCCTACTC
  TTCAATGATTCTGTGGTGCTGCTCAACATCACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACA
  CGGGGCTCGTACCGGGAAGACAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGA
  GCGTTGCCAAGGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCA
  CTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCTGACAGAGACC
  TCTTACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTTACTGACCTGGTGCCTGGACG
  AAAATACATGGCTACAGTCACCAGTATTAGTGGAGACTTAAAAAATTCCTCTTCAGTAAAAGGAAGAACA
  GTGCCTGCCCAAGTGACTGACTTGCATGTGGCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGA
  CCCAGGCACAAGGAGACGTAGAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGA
  AAGCATCTCCAGTGAGACCAGCAGATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTG
  GTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTCCCTTCCAGTG
  TGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTTTCCTGGCTGCTGGCGCCCGG
  AGATGTGGATAACTATGAGGTAACATTGTCTCATGACGGCAAGGTGGTTCAGTCCCTTGTCATTGCCAAG
  TCTGTCAGAGAATGTTCCTTCAGCTCCCTCACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGA
  GTGGCAAGTATGAAAATCACTCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGT
  TAGCAACTCAGCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTAT
  GAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAAAACGAATGTG
  TATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACAAAAAGTGGACAATATGAAGC
  CAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTTAAGGATCTAACATTGCGCAACAGGAGCACT
  GAGGACTTGCATGTGACTTGGTCAGGAGCTAATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCA
  ATGACATGAAAGTATTTCCTCCTTTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAAC
  ACCAGGCCGCCAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAG
  GGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGATAGCCTGACGG
  TGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCATTCAGGCACAGTCAAAAGGT
  TGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACGTTCCACAGACTGGAGGCCGGGGAGCAGTAC
  CAGATCATGATTGCCTCAGTCAGCGGGTCCCTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAG
  CATCTGTCCAAGGAGTAATTGCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGC
  TGCTGGTGTGGCAGAAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCA
  GAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAGATACAGATCC
  TAACTGTCAGTGGAGGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGAACAGTCCCAGCAGCTGTCAC
  CGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCCTTCCGCTGGACCGCCTCAGAGGGGGAGCTC
  AGCTGGTACAACATCTTTTTGTACAACCCAGATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAG
  TCCAGAGCTTCTCTTTCCAGAACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGG
  GGAGCTGTCTAATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCC
  AATCGGAACACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGACTTTTATGAGC
  TGATTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAGGACCTGACGGAGTGGCGGTT
  TCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTGGTAACTCACAGTGGAGATCTCAGCAATAAA
  GTCACAGCGGAGAGCAGAACAGCTCCAAGTCCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACAT
  CCTTGGCCATCACGTGGAAAGGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCC
  CAGAGATGCACTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTT
  CGTCCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACTTACAGCAAAC
  CAATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTGCATTGCCGGCCTCAGAACTCCAC
  GGCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTTGATGGTTATAGTATTGAATGCCGGAAAATG
  GACACCCAAGAAGTTGAGTTTTCCAGAAAGCTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAG
  TGCCCCATAAGAGGTACCTGGTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGA
  CAGCACTATCACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTG
  CTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAATGGAGCTGTGA
  AATACTTCACAGTGGTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAGCCAGAACAGCAGCACCCTCT
  CCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGGGTGTATCAGACTAATTATTTTGCCAGCAAA
  TGTGCCGAAAATCCTAACAGCAACTCCAAGAGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAG
  GTGGAAAATGCGATCCCACTCAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAAT
  CAGCATTCGAGCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGAC
  ACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGTGTGAGTGCTG
  GTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGCAGACAGAAAGTGAGCCATGG
  TCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGATCGACCATTATCTGTCCACTTAAACCTGGGC
  CAGAAAGGTAACCGGAAAACTTCTTGTCCAATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTAC
  AGGCTGACTCCAACTACCTTCTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATG
  TGACATTGCACTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACG
  CGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTACATCCCTGGCA
  ACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACCAAGGATGACTTCTGGAAAAT
  GGTGTGGGAACAAAACGTTCACAACATCGTCATGGTGACCCAGTGTGTTGAGAAGGGCCGAGTAAAGTGT
  GACCATTACTGGCCAGCGGACCAGGATTCCCTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGT
  CCGTCCTGCCTGAGTGGACCATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACT
  CATCCGCCACTTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAG
  TTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTGCACTGCAGTG
  CTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAGCAGTTAGACTCCAAAGACTC
  TGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCACAGGGTTCACATGGTCCAGACTGAGTGTCAG
  TATGTCTACCTACATCAGTGTGTAAGAGATGTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACC
  CCTTGTTTCCAATCTATGAAAATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001109754
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001109754.2, NP_001103224.1
• RefSeq Size: 11332 bp
• RefSeq ORF: 6648 bp
• Locus ID: 5787
• Cytogenetics: 12q15
• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Adherens junction
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]'
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.