PRDM8 (NM_020226) Human Untagged Clone

CAT#: SC318162

PRDM8 (untagged)-Human PR domain containing 8 (PRDM8), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PRDM8
• Synonyms: EPM10; KMT8D; PFM5
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_020226, the custom clone sequence may differ by one or more nucleotides
  ATGGAGGATACTGGCATCCAGCGAGGCATCTGGGATGGAGATGCCAAGGCTGTCCAACAA
  TGTCTGACAGATATTTTTACCAGCGTTTACACCACCTGCGACATCCCTGAGAATGCTATA
  TTTGGTCCCTGTGTCCTGAGCCATACTTCCCTATATGACAGCATAGCTTTCATAGCTCTC
  AAGTCTACTGACAAGAGAACAGTACCGTATATCTTTCGGGTAGACACCTCAGCAGCAAAT
  GGTTCCTCAGAAGGTCTCATGTGGCTGCGGTTGGTCCAATCGGCCAGAGATAAGGAAGAG
  CAGAACCTTGAAGCCTACATAAAAAACGGACAGCTGTTCTACCGCTCTCTCCGCAGGATT
  GCCAAAGACGAGGAGTTACTAGTTTGGTACGGGAAAGAACTGACTGAGTTACTCTTGCTC
  TGCCCCTCTAGATCCCACAACAAAATGAATGGGTCGTCCCCTTACACATGCCTGGAATGC
  AGCCAACGTTTCCAGTTTGAGTTCCCCTATGTGGCGCATCTGCGTTTCCGCTGCCCCAAG
  AGACTTCACAGCGCTGATATAAGTCCCCAAGACGAACAAGGCGGCGGCGTGGGCACCAAG
  GACCACGGGGGCGGCGGCGGCGGTGGCAAAGACCAGCAGCAGCAGCAGCAGGAGGCACCT
  TTAGGCCCGGGTCCCAAGTTTTGCAAAGCCGGCCCCCTCCACCACTACCCATCCCCCTCC
  CCGGAAAGCAGCAACCCATCCGCTGCCGCCGGCGGCAGCAGCGCGAAGCCATCCACAGAC
  TTCCACAACCTGGCCAGGGAGCTGGAAAACTCCCGGGGAGGCAGCAGCTGCTCCCCAGCC
  CAGAGCCTCAGCAGCGGTAGCGGCAGCGGCGGCGGCGGCGGCCACCAGGAGGCGGAGCTG
  AGTCCCGACGGCATCGCCACGGGCGGCGGCAAAGGAAAGAGGAAATTCCCGGAGGAGGCG
  GCGGAGGGCGGCGGTGGCGCTGGTCTGGTAGGGGGCCGGGGCCGCTTCGTAGAGCGGCCC
  CTCCCGGCCTCCAAGGAGGATCTGGTGTGCACACCGCAGCAGTACCGAGCCTCGGGCAGC
  TACTTCGGCCTGGAAGAGAACGGCCGCCTCTTCGCGCCGCCAAGTCCCGAGACGGGCGAG
  GCGAAGCGCAGCGCCTTCGTGGAGGTGAAGAAGGCTGCCCGCGCGGCCAGCCTGCAGGAG
  GAGGGGACAGCCGACGGCGCGGGAGTCGCCTCCGAGGACCAGGACGCTGGCGGCGGCGGC
  GGCTCCTCCACGCCCGCGGCCGCGTCACCGGTGGGCGCCGAGAAGCTGCTGGCCCCGCGG
  CCTGGGGGCCCGCTGCCCAGCCGGCTCGAGGGCGGCAGTCCTGCGAGGGGCAGCGCCTTC
  ACTTCGGTGCCGCAGCTGGGCAGCGCGGGCAGCACCAGCGGTGGGGGCGGAACGGGCGCC
  GGGGCCGCAGGCGGCGCGGGCGGGGGCCAGGGCGCCGCGTCGGACGAGCGCAAAAGCGCC
  TTCTCGCAGCCAGCACGCTCTTTCTCGCAGCTGTCCCCGCTGGTGCTGGGCCAGAAGCTG
  GGCGCGCTCGAGCCATGCCACCCCGCCGACGGCGTGGGCCCCACCAGACTCTATCCCGCC
  GCCGCGGACCCTCTAGCGGTGAAGCTCCAGGGGGCCGCGGACCTGAACGGAGGTTGCGGG
  TCCCTGCCGAGCGGCGGCGGCGGCCTGCCTAAGCAGAGCCCCTTCCTGTACGCCACCGCC
  TTCTGGCCCAAGAGCTCCGCTGCCGCTGCAGCCGCGGCTGCGGCGGCGGCCGCGGGGCCC
  TTGCAGCTGCAGCTGCCCTCGGCGCTCACGCTGCTGCCGCCCTCCTTCACCTCGCTGTGT
  CTGCCCGCGCAGAACTGGTGCGCCAAGTGCAATGCCTCCTTCCGCATGACCTCCGACCTG
  GTGTACCATATGAGGTCGCACCACAAAAAGGAGTATGCGATGGAGCCCTTGGTGAAGCGG
  CGGCGAGAGGAGAAACTCAAGTGCCCCATCTGCAATGAGTCCTTCAGGGAGCGCCACCAC
  CTCTCCAGGCACATGACCTCGCATAAT
  
• Restriction Sites: Please inquire
• ACCN: NM_020226
• ORF Size: 2070 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_020226.3, NP_064611.3
• RefSeq Size: 4118
• RefSeq ORF: 2070
• Locus ID: 56978
• Domains: SET
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
  Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.