ARHGEF7 (NM_001113513) Human Untagged Clone

CAT#: SC318960

ARHGEF7 (untagged)-Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ARHGEF7
• Synonyms: BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001113513, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGACCGATAATAGCAACAATCAACTGGTAGTAAGAGCAAAGTTTAACTTCCAGCAGACCAATGAGGACG
  AGCTTTCCTTCTCAAAAGGAGACGTCATCCATGTCACCCGTGTGGAAGAGGGAGGCTGGTGGGAGGGCAC
  ACTCAACGGCCGGACCGGCTGGTTCCCCAGCAACTACGTGCGCGAGGTCAAGGCCAGCGAGAAGCCTGTG
  TCTCCCAAATCAGGAACACTGAAGAGCCCTCCCAAAGGATTTGATACGACTGCCATAAACAAAAGCTATT
  ACAATGTGGTGCTACAGAATATTTTAGAAACAGAAAATGAATATTCTAAAGAACTTCAGACTGTGCTTTC
  AACGTACCTACGGCCATTGCAGACCAGTGAGAAGTTAAGTTCAGCAAACATTTCATATTTAATGGGAAAT
  CTAGAAGAAATATGTTCTTTCCAGCAAATGCTCGTACAGTCTTTAGAAGAATGCACCAAGTTGCCCGAAG
  CTCAGCAGAGAGTCGGAGGCTGCTTTTTAAACCTGATGCCACAGATGAAAACCCTGTACCTCACGTATTG
  TGCCAATCACCCTTCTGCAGTGAATGTCCTCACGGAACACAGTGAGGAGTTGGGGGAGTTCATGGAGACC
  AAAGGTGCCAGCAGCCCTGGGATTCTCGTGCTGACCACGGGCCTGAGCAAACCCTTCATGCGCCTGGATA
  AATACCCTACGCTGCTCAAAGAGCTCGAGAGACACATGGAGGATTATCATACAGATAGACAAGATATTCA
  AAAATCCATGGCTGCCTTCAAAAACCTTTCAGCCCAATGTCAAGAAGTCCGGAAGAGGAAAGAGCTTGAG
  CTGCAGATCCTGACGGAAGCCATCCGGAACTGGGAGGGCGATGACATTAAAACTCTGGGCAACGTCACTT
  ACATGTCCCAGGTCCTGATTCAGTGTGCCGGAAGTGAGGAAAAGAATGAAAGATATCTTCTACTCTTCCC
  AAATGTTTTGCTAATGTTGTCTGCCAGTCCTAGGATGAGTGGCTTTATCTATCAGGGAAAGCTTCCAACG
  ACAGGAATGACAATCACAAAGCTTGAGGACAGTGAAAATCATAGAAATGCATTTGAAATATCAGGGAGCA
  TGATTGAGCGGATATTAGTGTCGTGCAACAACCAGCAGGATCTGCAGGAATGGGTGGAGCACCTACAGAA
  GCAAACGAAGGTCACGTCTGTGGGAAACCCCACCATAAAGCCTCATTCAGTGCCATCTCATACCCTCCCC
  TCCCACCCGGTCACTCCGTCCAGCAAGCACGCAGACAGCAAGCCCGCGCCGCTGACGCCCGCCTACCACA
  CGCTGCCCCACCCCTCCCACCACGGCACCCCGCACACCACCATCAACTGGGGACCCCTGGAGCCTCCGAA
  AACACCCAAGCCCTGGAGCCTGAGCTGCCTGCGGCCCGCGCCTCCCCTCCGGCCCTCAGCTGCTCTCTGC
  TACAAGGAGGATCTTAGTAAGAGCCCTAAGACCATGAAAAAGCTGCTGCCCAAGCGCAAACCTGAACGGA
  AGCCTTCAGATGAGGAGTTCGCGTCCCGGAAAAGCACAGCTGCTTTGGAAGAAGATGCTCAGATTCTGAA
  AGTCATTGAAGCTTACTGCACCAGCGCCAAAACAAGGCAAACACTCAATTCAAGTTCACGCAAAGAATCT
  GCTCCACAAGTTTTGCTTCCAGAAGAAGAGAAAATTATAGTGGAAGAAACTAAAAGTAATGGTCAGACAG
  TGATAGAAGAAAAGAGTCTTGTGGATACCGTATATGCATTAAAGGATGAAGTTCAAGAATTAAGACAGGA
  CAACAAAAAGATGAAGAAATCTCTAGAGGAAGAACAGAGAGCCCGCAAAGACCTGGAGAAGCTGGTGAGG
  AAAGTCCTGAAGAACATGAATGATCCTGCCTGGGATGAGACCAATCTATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001113513
• ORF Size: 1941 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001113513.1, NP_001106985.1
• RefSeq Size: 4956
• RefSeq ORF: 1941
• Locus ID: 8874
• Protein Pathways: Regulation of actin cytoskeleton
• Gene Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]
  Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains a different 3' coding region and 3' UTR, compared to variant 1. It initiates translation at a downstream start codon. Variants 1, 5, 6, 18, and 19 all encode isoform a (also known as p85Cool-1), which has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform c.