HIP55 (DBNL) (NM_014063) Human Untagged Clone

CAT#: SC319311

DBNL (untagged)-Human drebrin-like (DBNL), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DBNL
• Synonyms: ABP1; HIP-55; HIP55; SH3P7
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014063.5 GCGGAGACTGCGGGGCGGGCCATGGCGGCGAACCTGAGCCGGAACGGGCCAGCGCTGCAA
  GAGGCCTACGTGCGGGTGGTCACCGAGAAGTCCCCGACCGACTGGGCTCTCTTTACCTAT
  GAAGGCAACAGCAATGACATCCGCGTGGCTGGCACAGGGGAGGGTGGCCTGGAGGAGATG
  GTGGAGGAGCTCAACAGCGGGAAGGTGATGTACGCCTTCTGCAGAGTGAAGGACCCCAAC
  TCTGGACTGCCCAAATTTGTCCTCATCAACTGGACAGGCGAGGGCGTGAACGATGTGCGG
  AAGGGAGCCTGTGCCAGCCACGTCAGCACCATGGCCAGCTTCCTGAAGGGGGCCCATGTG
  ACCATCAACGCACGGGCCGAGGAGGATGTGGAGCCTGAGTGCATCATGGAGAAGGTGGCC
  AAGGCTTCAGGTGCCAACTACAGCTTTCACAAGGAGAGTGGCCGCTTCCAGGACGTGGGA
  CCCCAGGCCCCAGTGGGCTCTGTGTACCAGAAGACCAATGCCGTGTCTGAGATTAAAAGG
  GTTGGTAAAGACAGCTTCTGGGCCAAAGCAGAGAAGGAGGAGGAGAACCGTCGGCTGGAG
  GAAAAGCGGCGGGCCGAGGAGGCACAGCGGCAGCTGGAGCAGGAGCGCCGGGAGCGTGAG
  CTGCGTGAGGCTGCACGCCGGGAGCAGCGCTATCAGGAGCAGGGTGGCGAGGCCAGCCCC
  CAGAGCAGGACGTGGGAGCAGCAGCAAGAAGTGGTTTCAAGGAACCGAAATGAGCAGGAG
  TCTGCCGTGCACCCGAGGGAGATTTTCAAGCAGAAGGAGAGGGCCATGTCCACCACCTCC
  ATCTCCAGTCCTCAGCCTGGCAAGCTGAGGAGCCCCTTCCTGCAGAAGCAGCTCACCCAA
  CCAGAGACCCACTTTGGCAGAGAGCCAGCTGCTGCCATCTCAAGGCCCAGGGCAGATCTC
  CCTGCTGAGGAGCCGGCGCCCAGCACTCCTCCATGTCTGGTGCAGGCAGAAGAGGAGGCT
  GTGTATGAGGAACCTCCAGAGCAGGAGACCTTCTACGAGCAGCCCCCACTGGTGCAGCAG
  CAAGGTGCTGGCTCTGAGCACATTGACCACCACATTCAGGGCCAGGGGCTCAGTGGGCAA
  GGGCTCTGTGCCCGTGCCCTGTACGACTACCAGGCAGCCGACGACACAGAGATCTCCTTT
  GACCCCGAGAACCTCATCACGGGCATCGAGGTGATCGACGAAGGCTGGTGGCGTGGCTAT
  GGGCCGGATGGCCATTTTGGCATGTTCCCTGCCAACTACGTGGAGCTCATTGAGTGAGGC
  TGAGGGCACATCTTGCCCTTCCCCTCTCAGACATGGCTTCCTTATTGCTGGAAGAGGAGG
  CCTGGGAGTTGACATTCAGCACTCTTCCAGGAATAGGACCCCCAGTGAGGATGAGGCCTC
  AGGGCTCCCTCCGGCTTGGCAGACTCAGCCTGTCACCCCAAATGCAGCAATGGCCTGGTG
  ATTCCCACACATCCTTCCTGCATCCCCCGACCCTCCCAGACAGCTTGGCTCTTGCCCCTG
  ACAGGATACTGAGCCAAGCCCTGCCTGTGGCCAAGCCCTGAGTGGCCACTGCCAAGCTGC
  GGGGAAGGGTCCTGAGCAGGGGCATCTGGGAGGCTCTGGCTGCCTTCTGCATTTATTTGC
  CTTTTTTCTTTTTCTCTTGCTTCTAAGGGGTGGTGGCCACCACTGTTTAGAATGACCCTT
  GGGAACAGTGAACGTAGAGAATTGTTTTTAGCAGAGTTTGTGACCAAAGTCAGAGTGGAT
  CATGGTGGTTTGGCAGCAGGGAATTTGTCTTGTTGGAGCCTGCTCTGTGCTCCCCACTCC
  ATTTCTCTGTCCCTCTGCCTGGGCTATGGGAAGTGGGGATGCAGATGGCCAAGCTCCCAC
  CCTGGGTATTCAAAAACGGCAGACACAACATGTTCCTCCACGCGGCTCACTCGATGCCTG
  CAGGCCCCAGTGTGTGCCTCAACTGATTCTGACTTCAGGAAAAGTAACACAGAGTGGCCT
  TGGCCTGTTGTCTTCCCCTATTTTCTGTCCCAGCTCATCCGTGTCTCTGAAGAACAAATA
  TGCTTTTGGACCACGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  A
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014063.5 unedited
  GACGTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGCGGAGACTGCG
  GGGCGGGCCATGGCGGCGAACCTGAGCCGGAACGGGCCAGCGCTGCAAGAGGCCTACGTG
  CGGGTGGTCACCGAGAAGTCCCCGACCGACTGGGCTCTCTTTACCTATGAAGGCAACAGC
  AATGACATCCGCGTGGCTGGCACAGGGGAGGGTGGCCTGGAGGAGATGGTGGAGGAGCTC
  AACAGCGGGAAGGTGATGTACGCCTTCTGCAGAGTGAAGGACCCCAACTCTGGACTGCCC
  AAATTTGTCCTCATCAACTGGACAGGCGAGGGCGTGAACGATGTGCGGAAGGGAGCCTGT
  GCCAGCCACGTCAGCACCATGGCCAGCTTCCTGAAGGGGGCCCATGTGACCATCAACGCA
  CGGGCCGAGGAGGATGTGGAGCCTGAGTGCATCATGGAGAAGGTGGCCAAGGCTTCAGGT
  GCCAACTACAGCTTTCACAAGGAGAGTGGCCGCTTCCAGGACGTGGGACCCCAGGCCCCA
  GTGGGCTCTGTGTACCAGAAGACCAATGCCGTGTCTGAGATTAAAAGGGTTGGTAAAGAC
  AGCTTCTGGGCCAAAGCAGAGAAGGAGGAGGAGAACCGTCGGCTGGAGGAAAAGCGGCGG
  GCCGAGGAGGCACAGCGGCAGCTGGAGCAGAGCGCCGGGAGCGTGAGCTGCGTGAGGCTG
  CACGCCGGGAGCAGCGCTATCAGAGCAGGGTGGCGAGGCCAGCCCCCAGAGCAGACGTGG
  GAGCAGCAGCAGAAGTGGTTTCAGACCCGAAATGAGCAGAGTCTGCCGTGCACCCGAGGG
  AGATTTTCAGCAGAGGAGGAGGGCATGTCCACCACTCATCTCCAGTCTCAGCTGCAGCTG
  AGGAGCCCGTTCTGCAGAGCAGCTTACTACCGGAGAACCTACTTGGTCAGAAAACCAGCC
  TG
• Restriction Sites: Please inquire
• ACCN: NM_014063
• ORF Size: 1296 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014063.5, NP_054782.2
• RefSeq Size: 2147
• RefSeq ORF: 1296
• Locus ID: 28988
• Domains: SH3, ADF
• Gene Summary: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) uses an alternate in-frame splice site compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.