Aph 1b (APH1B) (NM_031301) Human Untagged Clone

CAT#: SC319931

APH1B (untagged)-Human anterior pharynx defective 1 homolog B (C. elegans) (APH1B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: APH1B
• Synonyms: APH-1B; PRO1328; PSFL; TAAV688
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_031301.2 GGTTTCCGCGGTGGCCATGACTGCGGCCGTGTTCTTCGGCTGCGCCTTCATTGCCTTCGG
  GCCTGCGCTCGCCCTTTATGTCTTCACCATCGCCACCGAGCCGTTGCGTATCATCTTCCT
  CATCGCCGGAGCTTTCTTCTGGTTGGTGTCTCTACTGATTTCGTCCCTTGTTTGGTTCAT
  GGCAAGAGTCATTATTGACAACAAAGATGGACCAACACAGAAATATCTGCTGATCTTTGG
  AGCGTTTGTCTCTGTCTATATCCAAGAAATGTTCCGATTTGCATATTATAAACTCTTAAA
  AAAAGCCAGTGAAGGTTTGAAGAGTATAAACCCAGGTGAGACAGCACCCTCTATGCGACT
  GCTGGCCTATGTTTCTGGCTTGGGCTTTGGAATCATGAGTGGAGTATTTTCCTTTGTGAA
  TACCCTATCTGACTCCTTGGGGCCAGGCACAGTGGGCATTCATGGAGATTCTCCTCAATT
  CTTCCTTTATTCAGCTTTCATGACGCTGGTCATTATCTTGCTGCATGTATTCTGGGGCAT
  TGTATTTTTTGATGGCTGTGAGAAGAAAAAGTGGGGCATCCTCCTTATCGTTCTCCTGAC
  CCACCTGCTGGTGTCAGCCCAGACCTTCATAAGTTCTTATTATGGAATAAACCTGGCGTC
  AGCATTTATAATCCTGGTGCTCATGGGCACCTGGGCATTCTTAGCTGCGGGAGGCAGCTG
  CCGAAGCCTGAAACTCTGCCTGCTCTGCCAAGACAAGAACTTTCTTCTTTACAACCAGCG
  CTCCAGATAACCTCAGGGAACCAGCACTTCCCAAACCGCAGACTACATCTTTAGAGGAAG
  CACAACTGTGCCTTTTTCTGAAAATCCCTTTTTCTGGTGGAATTGAGAAAGAAATAAAAC
  TATGCAGATATGCGTTCCATACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_031301.2 unedited
  TCGATGTAGTGATTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCCATTACGGCC
  GGGGGGTTTCCGCGGTGGCCATGACTGCGGCCGTGTTCTTCGGCTGCGCCTTCATTGCCT
  TCGGGCCTGCGCTCGCCCTTTATGTCTTCACCATCGCCACCGAGCCGTTGCGTATCATCT
  TCCTCATCGCCGGAGCTTTCTTCTGGTTGGTGTCTCTACTGATTTCGTCCCTTGTTTGGT
  TCATGGCAAGAGTCATTATTGACAACAAAGATGGACCAACACAGAAATATCTGCTGATCT
  TTGGAGCGTTTGTCTCTGTCTATATCCAAGAAATGTTCCGATTTGCATATTATAAACTCT
  TAAAAAAAGCCAGTGAAGGTTTGAAGAGTATAAACCCAGGTGAGACAGCACCCTCTATGC
  GACTGCTGGCCTATGTTTCTGGCTTGGGCTTTGGAATCATGAGTGGAGTATTTTCCTTTG
  TGAATACCCTATCTGACTCCTTGGGGCCAGGCACAGTGGGCATTCATGGAGATTCTCCTC
  AATTCTTCCTTTATTCAGCTTTCATGACGCTGGTCATTATCTTGCTGCATGTATTCTGGG
  GCATTGTATTTTTTGATGGCTGTGAGAAGAAAAAGTGGGGCATCCTCCTTATCGTTCTCC
  TGACCCACCTGCTGGTGTCAGCCCAGACCTTCATAAGTTCTTATTATGGAATAAACCTGG
  CGTCAGCATTTATAATCCTGGTGCTCATGGGCACCTGGGCATTCTTAGCTGCGGGAGGCA
  GCTGCCGAAGCCTGAAACTCTGCCTGCTCTGCCAAGACAGACTTTCTTCTTTACAACCAG
  CGCTCCAGATACCTCAGGAACCAGCACTTCCCAAACCGCAGACTACATCTTTAGAGAGCA
  CAACTGTGCCTTTTCTGAAATCCTTTTCTGTGATGAAAGATAAACTATGCAGATTGCGTC
  TACTAAATAACAAAAAAAAAACTGTTCGCGCCCTCCGCCCCTCTAGC
• Restriction Sites: Please inquire
• ACCN: NM_031301
• ORF Size: 774 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_031301.2, NP_112591.2
• RefSeq Size: 939
• RefSeq ORF: 774
• Locus ID: 83464
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
  Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.