PRAK (MAPKAPK5) (NM_139078) Human Untagged Clone

CAT#: SC319941

MAPKAPK5 (untagged)-Human mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MAPKAPK5
• Synonyms: MAPKAP-K5; MK-5; MK5; PRAK
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_139078.1 GTGGCGCTGAGGCGGCGGCGGGAGCAGCGGCGCCGAGCTCTGCTTCGGCTTCGGCTTCGG
  CTTCGCGGCGGTGCAGGCGGCGGAGGCGGAGGCGCAGGCTCTTCTTTAGGACCTGGCGAG
  CCCAGGTCTAAGCGGCGGCCCCGCGAGGCCCTTGCACGGCGCCCCGGGTCGAGGCCCTCC
  CCGCCTCGCCCTACCCCAGGAGCCTGCCTCCCCAGCTGGGGATGAGGCTAGGAGGCGGCC
  GCGTGGGGCCCAGCACAAAGACCTGTCCCCAGGGGCCGCCGCCTCCGCCGCTGCTGCTGC
  CGCCAGCCTAGAGCCGCCCGCCGAAGCAGAGCCGGCGCCGGGGTCCTCATCCCCACCGGT
  CCCGAGGGGCGGCTGCTGCCCGTCGCCACGAGGCCCAGGGGCCCGAGTGCCGAGCCCTTT
  GCTCCCTCGGCCGCGCGGGGACAGGGCTGCTGAGCAGCCTCCGCCTCTCCCGGCTGTGGG
  GGCCCCACTGAGTATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAACTTCCAT
  TTTAGAAGAATACAGTATCAATTGGACTCAGAAGCTGGGAGCTGGAATTAGTGGTCCAGT
  TAGAGTCTGTGTAAAGAAATCTACTCAAGAACGGTTTGCGCTGAAAATTCTTCTTGATCG
  TCCAAAAGCTAGAAATGAGGTACGTCTGCACATGATGTGTGCCACACACCCAAACATAGT
  TCAGATTATTGAAGTGTTTGCTAACAGTGTCCAGTTTCCCCATGAGTCCAGCCCTAGGGC
  CCGACTCTTAATTGTAATGGAGATGATGGAAGGGGGAGAGCTATTTCACAGAATCAGCCA
  GCACCGGCACTTTACAGAGAAGCAAGCCAGCCAAGTAACAAAGCAGATAGCTTTGGCTCT
  GCGGCACTGTCACTTGTTAAACATTGCGCACAGAGACCTCAAGCCTGAAAATCTGCTTTT
  TAAGGATAACTCTTTGGATGCCCCAGTGAAGTTGTGTGACTTTGGATTTGCCAAGATTGA
  CCAAGGTGACTTGATGACACCCCAGTTCACCCCTTATTATGTAGCACCCCAGGTACTGGA
  GGCGCAAAGAAGGCATCAGAAGGAGAAATCTGGCATCATACCTACCTCACCGACGCCCTA
  CACTTACAACAAGAGCTGTGACTTGTGGTCCCTAGGGGTGATTATCTATGTGATGCTGTG
  CGGATACCCTCCTTTTTACTCCAAACACCACAGCCGGACTATCCCAAAGGATATGCGAAG
  AAAGATCATGACAGGCAGTTTTGAGTTCCCAGAGGAAGAGTGGAGTCAGATCTCAGAGAT
  GGCCAAAGATGTTGTGAGGAAGCTCCTGAAGGTCAAACCGGAGGAGAGACTCACCATCGA
  GGGAGTGCTGGACCACCCCTGGCTCAATTCCACCGAGGCCCTGGATAATGTGCTGCCTTC
  TGCTCAGCTGATGATGGACAAGGCAGTGGTTGCAGGAATCCAGCAGGCTCACGCGGAACA
  GTTGGCCAACATGAGAATCCAGGATCTGAAAGTCAGCCTCAAACCCCTGCACTCAGTGAA
  CAACCCCATTCTGCGGAAGAGGAAGTTACTTGGCACCAAGCCAAAGGACAGTGTCTATAT
  CCACGACCATGAGAATGGAGCCGAGGATTCCAATGTTGCCTTGGAAAAACTCCGAGATGT
  GATTGCTCAGTGTATTCTCCCCCAGGCTGGAGAGAATGAAGATGAGAAACTGAATGAAGT
  AATGCAGGAGGCTTGGAAGTATAACCGGGAATGCAAACTCCTAAGAGATACTCTGCAGAG
  CTTCAGCTGGAATGGTCGTGGATTCACAGATAAAGTAGATCGACTAAAACTGGCAGAAAT
  TGTGAAGCAGGTGATAGAAGAGCAAACCACGTCCCACGAATCCCAATAATGACAGCTTCA
  GACTTTGTTTTTTTAACAATTTGAAAAATTATTCTTTAATGTATAAAGTAATTTTATGTA
  AATTAATAAATCATAATTTCATTTCCAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_139078.1 unedited
  AAGTATCTTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGTGGCGCTG
  AGGCGGCGGCGGGAGCAGCGGCGCCGAGCTCTGCTTCGGCTTCGGCTTCGGCTTCGCGGC
  GGTGCAGGCGGCGGAGGCGGAGGCGCAGGCTCTTCTTTAGGACCTGGCGAGCCCAGGTCT
  AAGCGGCGGCCCCGCGAGGCCCTTGCACGGCGCCCCGGGTCGAGGCCCTCCCCGCCTCGC
  CCTACCCCAGGAGCCTGCCTCCCCAGCTGGGGATGAGGCTAGGAGGCGGCCGCGTGGGGC
  CCAGCACAAAGACCTGTCCCCAGGGGCCGGGGGCATCGCCACTGCTGCTGTCGCCAGACA
  AGAGCCGCCCGCAGAAAGAAAATTCTGTGGGGGGGCACTGAAACCCACCGGGAAA
• Restriction Sites: Please inquire
• ACCN: NM_139078
• ORF Size: 1422 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_139078.1, NP_620777.1
• RefSeq Size: 2066
• RefSeq ORF: 1422
• Locus ID: 8550
• Domains: pkinase
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: MAPK signaling pathway
• Gene Summary: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
  Transcript Variant: This variant (2) contains an extra 6 nt segment in the coding region when compared to variant 1. It encodes an isoform (2) longer by 2 aa, as compared to isoform 1.