Exonuclease 1 (EXO1) (NM_130398) Human Untagged Clone

CAT#: SC321416

EXO1 (untagged)-Human exonuclease 1 (EXO1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EXO1
• Synonyms: HEX1; hExoI
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_130398.2 GCGTTGCCGGCCGTGGGTGCTCTGGCCACAGTGAGTTAGGGGCGTCGGAGCGGGTTTCTC
  CAACCGCAATCGGCTCCGCTCAAGGGGAGGAGGAGAGTCCCTTCTCGGAAGGCCTAAGGA
  AACGTGTCGTCTGGAATGGGCTTGGGGGCCACGCCTGCACATCTCCGCGAGACAGAGGGA
  TAAAGTGAAGATGGTGCTGTTATTGTTACCTCGAGTGCCACATGCGACCTCTGAGATATG
  TACACAGTCATTCTTACTATCGCACTCAGCCATTCTTACTACGCTAAAGAAGAAATAATT
  ATTCGAGGATATTTGCCTGGCCCAGAAGAAACTTATGTAAATTTCATGAACTATTATATC
  CGTTTTCCTCGGAGTGAGAGAAAACTCTTTTTAGATATCATCTGAGAGAACTAGTGAATC
  CCAGTCACTGAGTGGAGTTGAGAGTCTAAGAACCTCTGAAATTTGAGAACTGCTGGACCA
  GAGCCTTTAGAGCTCTGATAAGGTGTCAACAGGGTAGTTAATTTGGCACCATGGGGATAC
  AGGGATTGCTACAATTTATCAAAGAAGCTTCAGAACCCATCCATGTGAGGAAGTATAAAG
  GGCAGGTAGTAGCTGTGGATACATATTGCTGGCTTCACAAAGGAGCTATTGCTTGTGCTG
  AAAAACTAGCCAAAGGTGAACCTACTGATAGGTATGTAGGATTTTGTATGAAATTTGTAA
  ATATGTTACTATCTCATGGGATCAAGCCTATTCTCGTATTTGATGGATGTACTTTACCTT
  CTAAAAAGGAAGTAGAGAGATCTAGAAGAGAAAGACGACAAGCCAATCTTCTTAAGGGAA
  AGCAACTTCTTCGTGAGGGGAAAGTCTCGGAAGCTCGAGAGTGTTTCACCCGGTCTATCA
  ATATCACACATGCCATGGCCCACAAAGTAATTAAAGCTGCCCGGTCTCAGGGGGTAGATT
  GCCTCGTGGCTCCCTATGAAGCTGATGCGCAGTTGGCCTATCTTAACAAAGCGGGAATTG
  TGCAAGCCATAATTACAGAGGACTCGGATCTCCTAGCTTTTGGCTGTAAAAAGGTAATTT
  TAAAGATGGACCAGTTTGGAAATGGACTTGAAATTGATCAAGCTCGGCTAGGAATGTGCA
  GACAGCTTGGGGATGTATTCACGGAAGAGAAGTTTCGTTACATGTGTATTCTTTCAGGTT
  GTGACTACCTGTCATCACTGCGTGGGATTGGATTAGCAAAGGCATGCAAAGTCCTAAGAC
  TAGCCAATAATCCAGATATAGTAAAGGTTATCAAGAAAATTGGACATTATCTCAAGATGA
  ATATCACGGTACCAGAGGATTACATCAACGGGTTTATTCGGGCCAACAATACCTTCCTCT
  ATCAGCTAGTTTTTGATCCCATCAAAAGGAAACTTATTCCTCTGAACGCCTATGAAGATG
  ATGTTGATCCTGAAACACTAAGCTACGCTGGGCAATATGTTGATGATTCCATAGCTCTTC
  AAATAGCACTTGGAAATAAAGATATAAATACTTTTGAACAGATCGATGACTACAATCCAG
  ACACTGCTATGCCTGCCCATTCAAGAAGTCATAGTTGGGATGACAAAACATGTCAAAAGT
  CAGCTAATGTTAGCAGCATTTGGCATAGGAATTACTCTCCCAGACCAGAGTCGGGTACTG
  TTTCAGATGCCCCACAATTGAAGGAAAATCCAAGTACTGTGGGAGTGGAACGAGTGATTA
  GTACTAAAGGGTTAAATCTCCCAAGGAAATCATCCATTGTGAAAAGACCAAGAAGTGCAG
  AGCTGTCAGAAGATGACCTGTTGAGTCAGTATTCTCTTTCATTTACGAAGAAGACCAAGA
  AAAATAGCTCTGAAGGCAATAAATCATTGAGCTTTTCTGAAGTGTTTGTGCCTGACCTGG
  TAAATGGACCTACTAACAAAAAGAGTGTAAGCACTCCACCTAGGACGAGAAATAAATTTG
  CAACATTTTTACAAAGGAAAAATGAAGAAAGTGGTGCAGTTGTGGTTCCAGGGACCAGAA
  GCAGGTTTTTTTGCAGTTCAGATTCTACTGACTGTGTATCAAACAAAGTGAGCATCCAGC
  CTCTGGATGAAACTGCTGTCACAGATAAAGAGAACAATCTGCATGAATCAGAGTATGGAG
  ACCAAGAAGGCAAGAGACTGGTTGACACAGATGTAGCACGTAATTCAAGTGATGACATTC
  CGAATAATCATATTCCAGGTGATCATATTCCAGACAAGGCAACAGTGTTTACAGATGAAG
  AGTCCTACTCTTTTGAGAGCAGCAAATTTACAAGGACCATTTCACCACCCACTTTGGGAA
  CACTAAGAAGTTGTTTTAGTTGGTCTGGAGGTCTTGGAGATTTTTCAAGAACGCCGAGCC
  CCTCTCCAAGCACAGCATTGCAGCAGTTCCGAAGAAAGAGCGATTCCCCCACCTCTTTGC
  CTGAGAATAATATGTCTGATGTGTCGCAGTTAAAGAGCGAGGAGTCCAGTGACGATGAGT
  CTCATCCCTTACGAGAAGGGGCATGTTCTTCACAGTCCCAGGAAAGTGGAGAATTCTCAC
  TGCAGAGTTCAAATGCATCAAAGCTTTCTCAGTGCTCTAGTAAGGACTCTGATTCAGAGG
  AATCTGATTGCAATATTAAGTTACTTGACAGTCAAAGTGACCAGACCTCCAAGCTATGTT
  TATCTCATTTCTCAAAAAAAGACACACCTCTAAGGAACAAGGTTCCTGGGCTATATAAGT
  CCAGTTCTGCAGACTCTCTTTCTACAACCAAGATCAAACCTCTAGGACCTGCCAGAGCCA
  GTGGGCTGAGCAAGAAGCCGGCAAGCATCCAGAAGAGAAAGCATCATAATGCCGAGAACA
  AGCCGGGGTTACAGATCAAACTCAATGAGCTCTGGAAAAACTTTGGATTTAAAAAAGATT
  CTGAAAAGCTTCCTCCTTGTAAGAAACCCCTGTCCCCAGTCAGAGATAACATCCAACTAA
  CTCCAGAAGCGGAAGAGGATATATTTAACAAACCTGAATGTGGCCGTGTTCAAAGAGCAA
  TATTCCAGTAAATGCAGACTGCTGCAAAGCTTTTGCCTGCAAGAGAATCTGATCAATTTG
  AAGTCCCTGTTTGGGAATGAGGCACTTATCAGCATGAAGAATTTTTTCTCATTCTGTGCC
  ATTTTAAAAATAGAATACATTTTGTATATTGACTTTAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_130398.2 unedited
  GCGATTGTATACGACTCCTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAG
  GAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCGGACCGA
  CGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAAAA
  CGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCACG
  AGGGCGTTGCCGGCCGTGGGTGCTCTGGCCACAGTGAGTTAGGGGCGTCGGAGCGGGTTT
  CTCCAACCGCAATCGGCTCCGCTCAAGGGGAGGAGGAGAGTCCCTTCTCGGAAGGCCTAA
  GGAAACGTGTCGTCTGGAATGGGCTTGGGGGCCACGCCTGCACATCTCCGCGAGACAGAG
  GGATAAAGTGAAGATGGTGCTGTTATTGTTACCTCGAGTGCCACATGCGACCTCTGAGAT
  ATGTACACAGTCATTCTTACTATCGCACTCAGCCATTCTTACTACGCTAAAGAAGAAATA
  ATTATTCGAGGATATTTGCCTGGCCCAGAAGAAACTTATGTAAATTTCATGAACTATTAT
  ATCCGTTTTCCTCGGAGTGAGAGAAAACTCTTTTTAGATATCATCTGAGAGAACTAGTGA
  ATCCCAGTCACTGAGTGGAGTTGAGAGTCTAAGAACCCTCTGAAATTTGAGAACTGCTGG
  ACCAGAGCCTTTAGAGCTCTGATAAGGTGTCAACAGGGTAGTTAATTTGGCACCATGGGG
  AAACAGGGATTGCTACATTTATCAAAGAAGCTTCAGAACCATCATGTCAGAGTATAAGGG
  CAGGTAGTAGCTGGGGATACATATTGCTGGCTCCAAAGGGCCTATTGGCTGGGGCTGAAA
  ACCTAGCAAGGTGACTACTGGAACGCATTGTAGATTTGTATGAACTTGGTAAAATGGTAC
  ATATCTCATGGAATTACAAGCCCATTCTCG
• Restriction Sites: Please inquire
• ACCN: NM_130398
• ORF Size: 2541 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_130398.2, NP_569082.1
• RefSeq Size: 3245
• RefSeq ORF: 2541
• Locus ID: 9156
• Domains: XPG_N, XPG_I
• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Mismatch repair
• Gene Summary: This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) includes a unique exon in its 5' UTR, as compared to variant 1. Both variants 1 and 2 encode isoform b.