PVRL4 (NECTIN4) (NM_030916) Human Untagged Clone

CAT#: SC321596

PVRL4 (untagged)-Human poliovirus receptor-related 4 (PVRL4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NECTIN4
• Synonyms: EDSS1; LNIR; nectin-4; PRR4; PVRL4
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_030916.1 CACAGCGTGGGAAGCAGCTCTGGGGGAGCTCGGAGCTCCCGATCACGGCTTCTTGGGGGT
  AGCTACGGCTGGGTGTGTAGAACGGGGCCGGGGCTGGGGCTGGGTCCCCTAGTGGAGACC
  CAAGTGCGAGAGGCAAGAACTCTGCAGCTTCCTGCCTTCTGGGTCAGTTCCTTATTCAAG
  TCTGCAGCCGGCTCCCAGGGAGATCTCGGTGGAACTTCAGAAACGCTGGGCAGTCTGCCT
  TTCAACCATGCCCCTGTCCCTGGGAGCCGAGATGTGGGGGCCTGAGGCCTGGCTGCTGCT
  GCTGCTACTGCTGGCATCATTTACAGGCCGGTGCCCCGCGGGTGAGCTGGAGACCTCAGA
  CGTGGTAACTGTGGTGCTGGGCCAGGACGCAAAACTGCCCTGCTTCTACCGAGGGGACTC
  CGGCGAGCAAGTGGGGCAAGTGGCATGGGCTCGGGTGGACGCGGGCGAAGGCGCCCAGGA
  ACTAGCGCTACTGCACTCCAAATACGGGCTTCATGTGAGCCCGGCTTACGAGGGCCGCGT
  GGAGCAGCCGCCGCCCCCACGCAACCCCCTGGACGGCTCAGTGCTCCTGCGCAACGCAGT
  GCAGGCGGATGAGGGCGAGTACGAGTGCCGGGTCAGCACCTTCCCCGCCGGCAGCTTCCA
  GGCGCGGCTGCGGCTCCGAGTGCTGGTGCCTCCCCTGCCCTCACTGAATCCTGGTCCAGC
  ACTAGAAGAGGGCCAGGGCCTGACCCTGGCAGCCTCCTGCACAGCTGAGGGCAGCCCAGC
  CCCCAGCGTGACCTGGGACACGGAGGTCAAAGGCACAACGTCCAGCCGTTCCTTCAAGCA
  CTCCCGCTCTGCTGCCGTCACCTCAGAGTTCCACTTGGTGCCTAGCCGCAGCATGAATGG
  GCAGCCACTGACTTGTGTGGTGTCCCATCCTGGCCTGCTCCAGGACCAAAGGATCACCCA
  CATCCTCCACGTGTCCTTCCTTGCTGAGGCCTCTGTGAGGGGCCTTGAAGACCAAAATCT
  GTGGCACATTGGCAGAGAAGGAGCTATGCTCAAGTGCCTGAGTGAAGGGCAGCCCCCTCC
  CTCATACAACTGGACACGGCTGGATGGGCCTCTGCCCAGTGGGGTACGAGTGGATGGGGA
  CACTTTGGGCTTTCCCCCACTGACCACTGAGCACAGCGGCATCTACGTCTGCCATGTCAG
  CAATGAGTTCTCCTCAAGGGATTCTCAGGTCACTGTGGATGTTCTTGACCCCCAGGAAGA
  CTCTGGGAAGCAGGTGGACCTAGTGTCAGCCTCGGTGGTGGTGGTGGGTGTGATCGCCGC
  ACTCTTGTTCTGCCTTCTGGTGGTGGTGGTGGTGCTCATGTCCCGATACCATCGGCGCAA
  GGCCCAGCAGATGACCCAGAAATATGAGGAGGAGCTGACCCTGACCAGGGAGAACTCCAT
  CCGGAGGCTGCATTCCCATCACACGGACCCCAGGAGCCAGCCGGAGGAGAGTGTAGGGCT
  GAGAGCCGAGGGCCACCCTGATAGTCTCAAGGACAACAGTAGCTGCTCTGTGATGAGTGA
  AGAGCCCGAGGGCCGCAGTTACTCCACGCTGACCACGGTGAGGGAGATAGAAACACAGAC
  TGAACTGCTGTCTCCAGGCTCTGGGCGGGCCGAGGAGGAGGAAGATCAGGATGAAGGCAT
  CAAACAGGCCATGAACCATTTTGTTCAGGAGAATGGGACCCTACGGGCCAAGCCCACGGG
  CAATGGCATCTACATCAATGGGCGGGGACACCTGGTCTGACCCAGGCCTGCCTCCCTTCC
  CTAGGCCTGGCTCCTTCTGTTGACATGGGAGATTTTAGCTCATCTTGGGGGCCTCCTTAA
  ACACCCCCATTTCTTGCGGAAGATGCTCCCCATCCCACTGACTGCTTGACCTTTACCTCC
  AACCCTTCTGTTCATCGGGAGGGCTCCACCAATTGAGTCTCTCCCACCATGCATGCAGGT
  CACTGTGTGTGTGCATGTGTGCCTGTGTGAGTGTTGACTGACTGTGTGTGTGTGGAGGGG
  TGACTGTCCGTGGAGGGGTGACTGTGTCCGTGGTGTGTATTATGCTGTCATATCAGAGTC
  AAGTGAACTGTGGTGTATGTGCCACGGGATTTGAGTGGTTGCGTGGGCAACACTGTCAGG
  GTTTGGCGTGTGTGTCATGTGGCTGTGTGTGACCTCTGCCTGAAAAAGCAGGTATTTTCT
  CAGACCCCAGAGCAGTATTAATGATGCAGAGGTTGGAGGAGAGAGGTGGAGACTGTGGCT
  CAGACCCAGGTGTGCGGGCATAGCTGGAGCTGGAATCTGCCTCCGGTGTGAGGGAACCTG
  TCTCCTACCACTTCGGAGCCATGGGGGCAAGTGTGAAGCAGCCAGTCCCTGGGTCAGCCA
  GAGGCTTGAACTGTTACAGAAGCCCTCTGCCCTCTGGTGGCCTCTGGGCCTGCTGCATGT
  ACATATTTTCTGTAAATATACATGCGCCGGGAGCTTCTTGCAGGAATACTGCTCCGAATC
  ACTTTTAATTTTTTTCTTTTTTTTTTCTTGCCCTTTCCATTAGTTGTATTTTTTATTTAT
  TTTTATTTTTATTTTTTTTTAGAGTTTGAGTCCAGCCTGGACGATATAGCCAGACCCTGT
  CTGTAAAAAAACCAAAACCCAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_030916.1 unedited
  GGGGTTTGTATACGACTCCTATAGGGCGGCCGGCAATTCGGCACGAGGCACAGCGTGGGA
  AGCAGCTCTGGGGGAGCTCGGAGCTCCCGATCACGGCTTCTTGGGGGTAGCTACGGCTGG
  GTGTGTAGAACGGGGCCGGGGCTGGGGCTGGGTCCCCTAGTGGAGACCCAAGTGCGAGAG
  GCAAGAACTCTGCAGCTTCCTGCCTTCTGGGTCAGTTCCTTATTCAAGTCTGCAGCCGGC
  TCCCAGGGAGATCTCGGTGGAACTTCAGAAACGCTGGGCAGTCTGCCTTTCAACCATGCC
  CCTGTCCCTGGGAGCCGAGATGTGGGGTTTCTGATGCCTGGCTGCTGCTGCTGCTACTGC
  TGGCATCATTTACAGGCCGGTGCCCCGCGGGTGAGCTGGAGACCTCAGACGTGGTAACTG
  TGGTGCTGGGCCAGGACGCAAAACTGCCCTGCTTCTACCGAGGGGACTCCGGCGAGCAAG
  TGGGGCAAGTGGCATGGGCTCGGGTGGACGCGGGCGAAGGCGCCCAGGAACTAGCGCTAC
  TGCACTCCAAATACGGGCTTCATGTGAGCCCGGCTTACGAGGGCCGCGTGGAGCAGCCGC
  CGCCCCCACGCAACCCCCTGGACGGCTCAGTGCTCCTGCGCAACGCAGTGCAGCGGATGA
  GGGCGAGTACGAGTGCCGGGTCAGCACCTTTCCCCGCCGGCAGCTTTCCAGCGCGGCTGC
  GGCTCCGAGTGCTGGTGCCTCCCCTGCCCTCACTGAATCCTGGTCCAGCACTAGAGAGGG
  CCAGGGCCCTGACCCTGGCAGCCTCCTGCACAGCTGAGGGCAGCCCAGCCCCAGCGTGAC
  CTGGACCACGGAGGTCAAGCACAACGTCAAGCCGTTCTTCAGGCACTCCCGCTCTGCTGC
  GTCACCTCAAAGTCCACTTGGTGCCTAGCCGCAGCCATGAATGGCAGCCCACTGACCT
• Restriction Sites: Please inquire
• ACCN: NM_030916
• ORF Size: 1533 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_030916.1, NP_112178.1
• RefSeq Size: 2744
• RefSeq ORF: 1533
• Locus ID: 81607
• Domains: ig, IGc2, IG
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Adherens junction
• Gene Summary: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. [provided by RefSeq, Jan 2011]