DUSP6 (NM_001946) Human Untagged Clone

CAT#: SC321781

DUSP6 (untagged)-Human dual specificity phosphatase 6 (DUSP6), transcript variant 1


  "NM_001946" in other vectors (6)

Reconstitution Protocol

USD 310.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol DUSP6
Synonyms HH19; MKP3; PYST1
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for NM_001946.2 GCCTCGCGCAGGGGGTGTGCGAGGCTGAGTCCAAGAGATAGCAAATCGAGTCTTAAATAA
TCCGGGGAGAAAGACGCCCGGGTAGATTTGAGGTGCAGCCTTGGAGGGAGGGATTAGAAG
CCGCTAGACTTTTTTTCCTCCCCTCTCAGTAGCACGGAGTCCGAATTAATTGGATTTCAT
TCACTGGGGAGGAACAAAAACTATCTGGGCAGCTTCATTGAGAGAGATTCATTGACACTA
AGAGCCAGCGGCTGCAGCTGGGTGCAGAGAGAACCTCCGGCTTTACTTCTGTCTCGTCTG
CCCCAACCGCTAGCCTCGGCTTGGGTAAGGCGAGGCGGAATTAAACCCCGCTCCGAGAGC
GGCAGCTTCGCGCGCGGTGCGCTCGGCCTATGCCTGCCCCGAGGGGCGTCTGGTAGGCAC
CCCGCCCTCTCCCGCAGCTCGACCCCCATGATAGATACGCTCAGACCCGTGCCCTTCGCG
TCGGAAATGGCGATCAGCAAGACGGTGGCGTGGCTCAACGAGCAGCTGGAGCTGGGCAAC
GAGCGGCTGCTGCTGATGGACTGCCGGCCGCAGGAGCTATACGAGTCGTCGCACATCGAG
TCGGCCATCAACGTGGCCATCCCGGGCATCATGCTGCGGCGCCTGCAGAAGGGTAACCTG
CCGGTGCGCGCGCTCTTCACGCGCGGCGAGGACCGGGACCGCTTCACCCGGCGCTGTGGC
ACCGACACAGTGGTGCTCTACGACGAGAGCAGCAGCGACTGGAACGAGAATACGGGCGGC
GAGTCGGTGCTCGGGCTGCTGCTCAAGAAGCTCAAGGACGAGGGCTGCCGGGCGTTCTAC
CTGGAAGGTGGCTTCAGTAAGTTCCAAGCCGAGTTCTCCCTGCATTGCGAGACCAATCTA
GACGGCTCGTGTAGCAGCAGCTCGCCGCCGTTGCCAGTGCTGGGGCTCGGGGGCCTGCGG
ATCAGCTCTGACTCTTCCTCGGACATCGAGTCTGACCTTGACCGAGACCCCAATAGTGCA
ACAGACTCGGATGGTAGTCCGCTGTCCAACAGCCAGCCTTCCTTCCCAGTGGAGATCTTG
CCCTTCCTCTACTTGGGCTGTGCCAAAGACTCCACCAACTTGGACGTGTTGGAGGAATTC
GGCATCAAGTACATCTTGAACGTCACCCCCAATTTGCCGAATCTCTTTGAGAACGCAGGA
GAGTTTAAATACAAGCAAATCCCCATCTCGGATCACTGGAGCCAAAACCTGTCCCAGTTT
TTCCCTGAGGCCATTTCTTTCATAGATGAAGCCCGGGGCAAGAACTGTGGTGTCTTGGTA
CATTGCTTGGCTGGCATTAGCCGCTCAGTCACTGTGACTGTGGCTTACCTTATGCAGAAG
CTCAATCTGTCGATGAACGATGCCTATGACATTGTCAAAATGAAAAAATCCAACATATCC
CCTAACTTCAACTTCATGGGTCAGCTGCTGGACTTCGAGAGGACGCTGGGACTCAGCAGC
CCATGTGACAACAGGGTTCCAGCACAGCAGCTGTATTTTACCACCCCTTCCAACCAGAAT
GTATACCAGGTGGACTCTCTGCAATCTACGTGAAAGACCCCACACCCCTCCTTGCTGGAA
TGTGTCTGGCCCTTCAGCAGTTTCTCTTGGCAGCATCAGCTGGGCTGCTTTCTTTGTGTG
TGGCCCCAGGTGTCAAAATGACACCAGCTGTCTGTACTAGACAAGGTTACCAAGTGCGGA
ATTGGTTAATACTAACAGAGAGATTTGCTCCATTCTCTTTGGAATAACAGGACATGCTGT
ATAGATACAGGCAGTAGGTTTGCTCTGTACCCATGTGTACAGCCTACCCATGCAGGGACT
GGGATTCGAGGACTTCCAGGCGCATAGGGTAGAACCAAATGATAGGGTAGGAGCATGTGT
TCTTTAGGGCCTTGTAAGGCTGTTTCCTTTTGCATCTGGAACTGACTATATAATTGTCTT
CAATGAAGACTAATTCAATTTTGCATATAGAGGAGCCAAAGAGAGATTTCAGCTCTGTAT
TTGTGGTATCAGTTTGGAAAAAAAAATCTGATACTCCATTTGATTATTGTAAATATTTGA
TCTTGAATCACTTGACAGTGTTTGTTTGAATTGTGTTTGTTTTTTCCTTTGATGGGCTTA
AAAGAAATTATCCAAAGGGAGAAAGAGCAGTATGCCACTTCTTAAAACAGAACAAAACAA
AAAAAGAAAATTGTGCTCTTTTCTAATCCAAAGGGTATATTTGCAGCATGCTTGACTTTA
CCAATTCTGATGACATCTTTACGGACACTATTATCACTAAGACCTTGTTATGGCGAAGTC
TTTAGTCTTTTTCATGTATTTTCCTCATGATTTTTTCTCTTTATGTAGTTTGACTATGCC
TTACCTTTGTAAATATTTTTGCTTGTGTTGTCGCAAAAGGGATAATCTGGGAAAGACACC
AAATCATGGGCTCACTTTAAAAAAAGAAAGAATAAAAAAACCTTCAGCTGTGCTAAACAG
TATATTACCTCTGTATAAAATTCTTCAGGGAGTGTCACCTCAAATGCAATACTTTGGGTT
GGTTTCTTTCCTTTAAAAAAATTTGTATAAAACTGGAAGTGTGTGTGTGTGAGCATGGGT
ACCCATTTGATAAGAGAAATGCATTTGATTGTGAAGAAGGGAGAGTTAAATTCTCCATTA
TGTTCGTGGTGTAAAGTTTAGAGCTGGAATTTATTATAAGAATGTAAAACCTTAAATTAT
TAATAAATAACTATTTTGGCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_001946
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001946.2, NP_001937.2
RefSeq Size 2842 bp
RefSeq ORF 1146 bp
Locus ID 1848
Cytogenetics 12q21.33
Domains DSPc, RHOD
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
Gene Summary 'The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]'
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

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