IL1 Receptor II (IL1R2) (NM_173343) Human Untagged Clone

CAT#: SC321912

IL1R2 (untagged)-Human interleukin 1 receptor, type II (IL1R2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IL1R2
• Synonyms: CD121b; IL1RB; MGC47725
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_173343.1 CCCGTGAGGAGGAAAAGGTGTGTCCGCTGCCACCCAGTGTGAGCGGGTGACACCACCCGG
  TTAGGAAATCCCAGCTCCCAAGAGGGTATAAATCCCTGCTTTACTGCTGAGCTCCTGCTG
  GAGGTGAAAGTCTGGCCTGGCAGCCTTCCCCAGGTGAGCAGCAACAAGGCCACGTGCTGC
  TGGGTCTCAGTCCTCCACTTCCCGTGTCCTCTGGAAGTTGTCAGGAGCAATGTTGCGCTT
  GTACGTGTTGGTAATGGGAGTTTCTGCCTTCACCCTTCAGCCTGCGGCACACACAGGGGC
  TGCCAGAAGCTGCCGGTTTCGTGGGAGGCATTACAAGCGGGAGTTCAGGCTGGAAGGGGA
  GCCTGTAGCCCTGAGGTGCCCCCAGGTGCCCTACTGGTTGTGGGCCTCTGTCAGCCCCCG
  CATCAACCTGACATGGCATAAAAATGACTCTGCTAGGACGGTCCCAGGAGAAGAAGAGAC
  ACGGATGTGGGCCCAGGACGGTGCTCTGTGGCTTCTGCCAGCCTTGCAGGAGGACTCTGG
  CACCTACGTCTGCACTACTAGAAATGCTTCTTACTGTGACAAAATGTCCATTGAGCTCAG
  AGTTTTTGAGAATACAGATGCTTTCCTGCCGTTCATCTCATACCCGCAAATTTTAACCTT
  GTCAACCTCTGGGGTATTAGTATGCCCTGACCTGAGTGAATTCACCCGTGACAAAACTGA
  CGTGAAGATTCAATGGTACAAGGATTCTCTTCTTTTGGATAAAGACAATGAGAAATTTCT
  AAGTGTGAGGGGGACCACTCACTTACTCGTACACGATGTGGCCCTGGAAGATGCTGGCTA
  TTACCGCTGTGTCCTGACATTTGCCCATGAAGGCCAGCAATACAACATCACTAGGAGTAT
  TGAGCTACGCATCAAGAAAAAAAAAGAAGAGACCATTCCTGTGATCATTTCCCCCCTCAA
  GACCATATCAGCTTCTCTGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAAC
  CGGCACACCCTTAACCACCATGCTGTGGTGGACGGCCAATGACACCCACATAGAGAGCGC
  CTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAATATTCAGAAAATAATGAGAA
  CTACATTGAAGTGCCATTGATTTTTGATCCTGTCACAAGAGAGGATTTGCACATGGATTT
  TAAATGTGTTGTCCATAATACCCTGAGTTTTCAGACACTACGCACCACAGTCAAGGAAGC
  CTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTTTCACTGGCCTTCTTGGTTTT
  GGGGGGAATATGGATGCACAGACGGTGCAAACACAGAACTGGAAAAGCAGATGGTCTGAC
  TGTGCTATGGCCTCATCATCAAGACTTTCAATCCTATCCCAAGTGAAATAAATGGAATGA
  AATAATTCAAACACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_173343.1 unedited
  GGCATTTGTATACGACTCCTATAGGGCGGCTCTGGCGATCGCGGCGCGCCGGTACCGGTC
  CGGAATTCCCGGGATCCCGTGAGGAGGAAAAGGTGTGTCCGCTGCCACCCAGTGTGAGCG
  GGTGACACCACCCGGTTAGGAAATCCCAGCTCCCAAGAGGGTATAAATCCCTGCTTTACT
  GCTGAGCTCCTGCTGGAGGTGAAAGTCTGGCCTGGCAGCCTTCCCCAGGTGAGCAGCAAC
  AAGGCCACGTGCTGCTGGGTCTCAGTCCTCCACTTCCCGTGTCCTCTGGAAGTTGTCAGG
  AGCAATGTTGCGCTTGTACGTGTTGGTAATGGGAGTTTCTGCCTTCACCCTTCAGCCTGC
  GGCACACACAGGGGCTGCCAGAAGCTGCCGGTTTCGTGGGAGGCATTACAAGCGGGAGTT
  CAGGCTGGAAGGGGAGCCTGTAGCCCTGAGGTGCCCCCAGGTGCCCTACTGGTTGTGGGC
  CTCTGTCAGCCCCCGCATCAACCTGACATGGCATAAAAATGACTCTGCTAGGACGGTCCC
  AGGAGAAGAAGAGACACGGATGTGGGCCCAGGACGGTGCTCTGTGGCTTCTGCCAGCCTT
  GCAGAGGACTCTGGCACCTACGTCTGCACTACTAGAAATGCTTCTTACTGTGACAAAATG
  TCCATTGAGCTCAGAGTTTTTGAGAATACAGATGCTTTCCTGCCGTTCATCTCATACCCG
  CAAATTTTAACCTTGTCAACCTCTGGGGTATTAGTATGCCCTGACCTGAGTGAATTCCCC
  GTGACAAAACTGACGTGAGATTCAATGGTACAAGATTCTCTTCTTTGATAAAGACATGAG
  AATTTCTAGTGTGAAGGGGACCACTCACTACTCGTACACGATGTGCCCTGCAGATGCTGC
  TATACCGCTGTGTTCTGACATTGCCATGGAAAGCCAGCATC
• Restriction Sites: Please inquire
• ACCN: NM_173343
• ORF Size: 1197 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_173343.1, NP_775465.1
• RefSeq Size: 1436
• RefSeq ORF: 1197
• Locus ID: 7850
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway
• Gene Summary: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.